Page last updated: 2024-12-07

omega-(4-iodophenyl)pentadecanoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

omega-(4-iodophenyl)pentadecanoic acid: imaging agent; RN given refers to parent cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID123810
CHEMBL ID128251
SCHEMBL ID290025
MeSH IDM0084679

Synonyms (26)

Synonym
CHEMBL128251
iocanlidic acid
15-(4-iodophenyl)pentadecanoic acid
80479-93-2
15-(4-iodophenyl)-pentadecanecarboxylic acid
4-(iodophenyl)pentadecanoic acid
123i-pppa
oippda
ippa
omega-(p-iodophenyl)pentadecanoic acid
p-ippa
omega-(4-iodophenyl)pentadecanoic acid
benzenepentadecanoic acid, 4-(iodo-123i)-
iodo-para-phenyldecanoic acid
benzenepentadecanoicacid, 4-iodo-
SCHEMBL290025
DTXSID70230357
15-(p-iodophenyl)pentadecanoic acid
naphthalene, 1-fluoro-7-methoxy-
mfcd00040778
sr-01000945061
SR-01000945061-1
15-(4-iodophenyl)pentadecanecarboxylic acid (ippa)
FT-0758109
omega-(4-iodophenyl)pentadecanoic-acid
CS-0455941

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" There were no significant adverse effects from the administration of IPPA."( Preliminary report of an ongoing phase I/II dose range, safety and efficacy study of iodine-123-phenylpentadecanoic acid for the identification of viable myocardium.
Hansen, CL, 1994
)
0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Replicase polyprotein 1abBetacoronavirus England 1IC50 (µMol)10.00000.00403.43889.5100AID1640022
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC50 (µMol)2.25000.00022.45859.9600AID1640021
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
3'-5'-RNA exonuclease activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
cysteine-type endopeptidase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
mRNA 5'-cap (guanine-N7-)-methyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
mRNA (nucleoside-2'-O-)-methyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
mRNA guanylyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
RNA endonuclease activity, producing 3'-phosphomonoestersReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
ISG15-specific peptidase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
5'-3' RNA helicase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
protein guanylyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
double membrane vesicle viral factory outer membraneReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID169389Liver uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 4 hours1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169530Lungs uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 60 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169143Blood uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 4 hours1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169529Lungs uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 5 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID171618Thyroid uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 60 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169384Kidneys uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 4 hours1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID171617Thyroid uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 5 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID168864Heart uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 4 hours1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169142Blood uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 30 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169387Kidneys uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 60 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID168867Heart uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 60 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169146Blood uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 60 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169386Kidneys uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 5 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169392Liver uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 60 min1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID171614Thyroid uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 30 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169527Lungs uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 4 hours1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID168866Heart uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 5 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169391Liver uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 5 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169383Kidneys uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 30 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID168863Heart uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 30 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169388Liver uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 30 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169526Lungs uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 30 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID171615Thyroid uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 4 hours1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
AID169145Blood uptake in percent injected dose/gram (range) was determined in female fischer rat after 1251-labelled compound complexed with bovine serum albumin was injected intravenously after 5 minutes1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (108)

TimeframeStudies, This Drug (%)All Drugs %
pre-199043 (39.81)18.7374
1990's51 (47.22)18.2507
2000's10 (9.26)29.6817
2010's1 (0.93)24.3611
2020's3 (2.78)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.20 (24.57)
Research Supply Index4.84 (2.92)
Research Growth Index5.04 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials6 (5.04%)5.53%
Reviews13 (10.92%)6.00%
Case Studies1 (0.84%)4.05%
Observational0 (0.00%)0.25%
Other99 (83.19%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]