Compounds > 2,3-bis(3'-hydroxybenzyl)butyrolactone
Page last updated: 2024-09-02

2,3-bis(3'-hydroxybenzyl)butyrolactone and tamoxifen

2,3-bis(3'-hydroxybenzyl)butyrolactone has been researched along with tamoxifen in 6 studies

Compound Research Comparison

Studies
(2,3-bis(3'-hydroxybenzyl)butyrolactone)		Trials
(2,3-bis(3'-hydroxybenzyl)butyrolactone)		Recent Studies (post-2010)
(2,3-bis(3'-hydroxybenzyl)butyrolactone)		Studies
(tamoxifen)		Trials
(tamoxifen)		Recent Studies (post-2010) (tamoxifen)
3193212420,6302,2276,256

Protein Interaction Comparison

ProteinTaxonomy2,3-bis(3'-hydroxybenzyl)butyrolactone (IC50)tamoxifen (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.46
Serine/threonine-protein kinase D3Homo sapiens (human)1
Bile salt export pumpHomo sapiens (human)10
Epidermal growth factor receptorHomo sapiens (human)3.553
Estrogen receptorHomo sapiens (human)0.9266
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.949
Protein kinase C gamma typeHomo sapiens (human)1
Protein kinase C beta typeHomo sapiens (human)1
Tyrosine-protein kinase LckHomo sapiens (human)8.033
Tyrosine-protein kinase FynHomo sapiens (human)1.195
Progesterone receptorHomo sapiens (human)0.1288
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.472
Muscarinic acetylcholine receptor M2Homo sapiens (human)7.793
Muscarinic acetylcholine receptor M4Homo sapiens (human)4.817
ATP-dependent translocase ABCB1Homo sapiens (human)6.4
Muscarinic acetylcholine receptor M5Homo sapiens (human)2.585
Alpha-2A adrenergic receptorHomo sapiens (human)1.935
Adenosine receptor A3Homo sapiens (human)3.701
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.829
Steroid hormone receptor ERR1Homo sapiens (human)0.2
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.967
Beta-3 adrenergic receptorHomo sapiens (human)7.703
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)3.701
Protein kinase C alpha typeHomo sapiens (human)1
Alpha-2B adrenergic receptorHomo sapiens (human)3.518
Muscarinic acetylcholine receptor M3Homo sapiens (human)2.974
Substance-K receptorHomo sapiens (human)3.67
D(1A) dopamine receptorHomo sapiens (human)8.502
Prostaglandin G/H synthase 1Homo sapiens (human)4.391
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.472
Thromboxane-A synthase Homo sapiens (human)0.916
Protein kinase C eta typeHomo sapiens (human)1
Histamine H2 receptorHomo sapiens (human)9.396
Alpha-1D adrenergic receptorHomo sapiens (human)4.982
5-hydroxytryptamine receptor 2AHomo sapiens (human)4.801
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.46
Adenosine receptor A2aHomo sapiens (human)7.099
Sodium-dependent serotonin transporterHomo sapiens (human)2.334
D(3) dopamine receptorHomo sapiens (human)1.072
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.084
Protein kinase C iota typeHomo sapiens (human)1
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)3.701
5-hydroxytryptamine receptor 6Homo sapiens (human)2.679
Estrogen-related receptor gammaHomo sapiens (human)0.0622
Sodium-dependent dopamine transporter Homo sapiens (human)1.841
Protein kinase C epsilon typeHomo sapiens (human)1
Protein kinase C theta typeHomo sapiens (human)1
Protein kinase C zeta typeHomo sapiens (human)1
Protein kinase C delta typeHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.2759
Platelet-activating factor acetylhydrolaseHomo sapiens (human)0.904
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiens (human)0.012
Serine/threonine-protein kinase D1Homo sapiens (human)1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.967
Estrogen receptor betaHomo sapiens (human)0.7809
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.021
7-dehydrocholesterol reductaseHomo sapiens (human)0.012

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kurzer, MS; Wang, C1
Chen, J; Thompson, LU1
Bombelli, R; Cosentino, M; Crema, F; Delle Canne, MG; Ferrari, M; Lecchini, S; Legnaro, M; Luini, A; Luzzani, M; Marino, F; Paracchini, S; Rasini, E1
Abrahamsson, A; Dabrosin, C; Lindahl, G; Saarinen, N1
Abarzua, S; Briese, V; Piechulla, B; Richter, DU; Serikawa, T; Szewczyk, M1
Abrahamsson, A; Dabrosin, C; Lindahl, G1

Other Studies

6 other study(ies) available for 2,3-bis(3'-hydroxybenzyl)butyrolactone and tamoxifen

ArticleYear
Effects of phytoestrogens on DNA synthesis in MCF-7 cells in the presence of estradiol or growth factors.
    Nutrition and cancer, 1998, Volume: 31, Issue:2

    Topics: 4-Butyrolactone; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chamomile; Coumestrol; DNA, Neoplasm; Epidermal Growth Factor; Estradiol; Estrogens, Non-Steroidal; Female; Flavonoids; Genistein; Humans; Insulin; Isoflavones; Lignans; Luteolin; Oils, Volatile; Phytoestrogens; Plant Preparations; Plants, Medicinal; Tamoxifen; Tumor Cells, Cultured

1998
Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro.
    Breast cancer research and treatment, 2003, Volume: 80, Issue:2

    Topics: 4-Butyrolactone; Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Female; Humans; Lignans; Neoplasm Invasiveness; Neoplasm Metastasis; Phytotherapy; Receptors, Estrogen; Tamoxifen

2003
Estrogenic activity of 7-hydroxymatairesinol potassium acetate (HMR/lignan) from Norway spruce (Picea abies) knots and of its active metabolite enterolactone in MCF-7 cells.
    Pharmacological research, 2007, Volume: 56, Issue:2

    Topics: 4-Butyrolactone; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation, Neoplastic; Humans; Lignans; Phytoestrogens; Picea; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Tamoxifen

2007
Tamoxifen, flaxseed, and the lignan enterolactone increase stroma- and cancer cell-derived IL-1Ra and decrease tumor angiogenesis in estrogen-dependent breast cancer.
    Cancer research, 2011, Jan-01, Volume: 71, Issue:1

    Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Cell Line, Tumor; Estrogen Receptor alpha; Estrogens; Female; Flax; Humans; Immunohistochemistry; Interleukin 1 Receptor Antagonist Protein; Lignans; Macrophages; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Neovascularization, Pathologic; Stromal Cells; Tamoxifen

2011
Antiproliferative activity of lignans against the breast carcinoma cell lines MCF 7 and BT 20.
    Archives of gynecology and obstetrics, 2012, Volume: 285, Issue:4

    Topics: 4-Butyrolactone; Anticarcinogenic Agents; Breast Neoplasms; Butylene Glycols; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogens; Female; Furans; Humans; Lignans; Phytoestrogens; Selective Estrogen Receptor Modulators; Tamoxifen

2012
Dietary flaxseed and tamoxifen affect the inflammatory microenvironment in vivo in normal human breast tissue of postmenopausal women.
    European journal of clinical nutrition, 2019, Volume: 73, Issue:9

    Topics: 4-Butyrolactone; Breast; Breast Neoplasms; Diet; Estrogen Antagonists; Female; Flax; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-18; Interleukin-1beta; Interleukin-8; Lignans; Matrix Metalloproteinase 9; Microdialysis; Middle Aged; Postmenopause; Seeds; Tamoxifen; Tumor Microenvironment

2019
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