Compounds > uk 1
Page last updated: 2024-12-07

uk 1

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Description

UK 1: a cytotoxic metabolite from Streptomyces sp. 517-02; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID127748
CHEMBL ID111574
SCHEMBL ID11979724
MeSH IDM0220477

Synonyms (19)

Synonym
methyl 2-(2-(2-hydroxyphenyl)benzo[d]oxazol-4-yl)benzo[d]oxazole-4-carboxylate
bdbm50147399
2''-(2-hydroxy-phenyl)-[2,4'']bibenzooxazolyl-4-carboxylic acid methyl ester
uk 1
CHEMBL111574 ,
151271-53-3
methyl 2'-(2-hydroxyphenyl)-(2,4'-bibenzoxazole)-4-carboxylate
uk-1
(2,4'-bibenzoxazole)-4-carboxylic acid, 2'-(2-hydroxyphenyl)-, methyl ester
methyl 2-[2-(2-hydroxyphenyl)-1,3-benzoxazol-4-yl]-1,3-benzoxazole-4-carboxylate
SCHEMBL11979724
HB4117
methyl 2'-(2-hydroxyphenyl)-oxazole]-4-carboxylate; 2'-(2-hydroxyphenyl)-(2,4'-bibenzoxazole)-4-carboxylic acid methyl ester
J-008796
methyl 2'-(2-hydroxyphenyl)-[2,4'-bibenzo[d]oxazole]-4-carboxylate
[2,4'-bibenzoxazole]-4-carboxylic acid, 2'-(2-hydroxyphenyl)-, methyl ester
2'-(2-hydroxyphenyl)-[2,4'-bibenzoxazole]-4-carboxylic acid, methyl ester
CS-0106677
HY-129558
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA topoisomerase 2-alphaHomo sapiens (human)IC50 (µMol)41.00000.48004.35649.9400AID57356; AID57357
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (16)

Processvia Protein(s)Taxonomy
hematopoietic progenitor cell differentiationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topological changeDNA topoisomerase 2-alphaHomo sapiens (human)
DNA ligationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA damage responseDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome segregationDNA topoisomerase 2-alphaHomo sapiens (human)
female meiotic nuclear divisionDNA topoisomerase 2-alphaHomo sapiens (human)
apoptotic chromosome condensationDNA topoisomerase 2-alphaHomo sapiens (human)
embryonic cleavageDNA topoisomerase 2-alphaHomo sapiens (human)
regulation of circadian rhythmDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of apoptotic processDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of single stranded viral RNA replication via double stranded DNA intermediateDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIDNA topoisomerase 2-alphaHomo sapiens (human)
rhythmic processDNA topoisomerase 2-alphaHomo sapiens (human)
negative regulation of DNA duplex unwindingDNA topoisomerase 2-alphaHomo sapiens (human)
resolution of meiotic recombination intermediatesDNA topoisomerase 2-alphaHomo sapiens (human)
sister chromatid segregationDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (13)

Processvia Protein(s)Taxonomy
magnesium ion bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
chromatin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
RNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activityDNA topoisomerase 2-alphaHomo sapiens (human)
protein kinase C bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP-dependent activity, acting on DNADNA topoisomerase 2-alphaHomo sapiens (human)
DNA binding, bendingDNA topoisomerase 2-alphaHomo sapiens (human)
protein homodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
ubiquitin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein heterodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (12)

Processvia Protein(s)Taxonomy
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
nuclear chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
centrioleDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome, centromeric regionDNA topoisomerase 2-alphaHomo sapiens (human)
condensed chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
male germ cell nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
cytoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complexDNA topoisomerase 2-alphaHomo sapiens (human)
protein-containing complexDNA topoisomerase 2-alphaHomo sapiens (human)
ribonucleoprotein complexDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (27)

Assay IDTitleYearJournalArticle
AID320493Cytotoxicity against human MCF7 cells after 72 hrs in presence of CuCl22008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.
AID373320Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay2009European journal of medicinal chemistry, Apr, Volume: 44, Issue:4
New transition metal ion complexes with benzimidazole-5-carboxylic acid hydrazides with antitumor activity.
AID718400Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay2012Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24
Synthesis and docking studies of novel antitumor benzimidazoles.
AID150661Inhibitory activity of compound against P388 murine cell line; range is 0.3 uM-1.6 uM2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs.
AID320488Cytotoxicity against human A549 cells by Alamar blue assay2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.
AID1063618Inhibition of Dengue virus helicase2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication.
AID1063614Antiviral activity against HCV infected in human Huh7ET cells assessed as inhibition of viral replication by luciferase reporter gene assay/RNA blot hybridization analysis2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication.
AID320495Cytotoxicity against human A549 cells after 72 hrs2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.
AID1063619Inhibition of Japanese encephalitis virus helicase2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication.
AID320487Cytotoxicity against human MCF7 cells by Alamar blue assay2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.
AID1063612Cytotoxicity against human Huh7ET cells by neutral red assay2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication.
AID156163Cytotoxicity of compound against PC-3 cell line2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs.
AID82838Cytotoxicity of compound against HL60 cell line2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs.
AID1063617Inhibition of HCV NS3 NTPase/helicase domain expressed in Escherichia coli BL21 using dsDNA as substrate assessed as strand separation of [32P]-labeled oligonucleotides after 30 mins by SDS-gel electrophoresis2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication.
AID57357Inhibitory concentration against human DNA topoisomerase II, alpha mediated relaxation of pBR3222004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs.
AID320494Cytotoxicity against human A549 cells after 24 hrs2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.
AID57356Inhibitory activity of compound against human DNA topoisomerase II, alpha was evaluated by ability to interfere with the relaxation of supercoiled plasmid DNA2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs.
AID1063615Inhibition of HCV ATPase activity of NS3 NTPase/helicase domain expressed in Escherichia coli BL21 after 30 mins by thin layer chromatography in presence of [gamma-32P]ATP2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication.
AID320496Cytotoxicity against human A549 cells after 24 hrs in presence of CuCl22008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.
AID1063613Inhibition of HCV NS5B RNA dependent RNA polymerase at 100 uM2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication.
AID1063610Selectivity index, ratio of CC50 for human Huh7ET cells to EC50 for HCV infected in human Huh7ET cells2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication.
AID373321Cytotoxicity against human A549 cells after 72 hrs by Alamar Blue assay2009European journal of medicinal chemistry, Apr, Volume: 44, Issue:4
New transition metal ion complexes with benzimidazole-5-carboxylic acid hydrazides with antitumor activity.
AID320497Cytotoxicity against human A549 cells after 72 hrs in presence of CuCl22008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.
AID1063616Inhibition of HCV NS3 NTPase/helicase domain expressed in Escherichia coli BL21 using dsRNA as substrate assessed as strand separation of [32P]-labeled oligonucleotides after 30 mins by SDS-gel electrophoresis2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication.
AID320492Cytotoxicity against human MCF7 cells after 24 hrs in presence of CuCl22008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.
AID320490Cytotoxicity against human MCF7 cells after 24 hrs2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.
AID320491Cytotoxicity against human MCF7 cells after 72 hrs2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (27.27)18.2507
2000's6 (54.55)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 50.07

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index50.07 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index72.96 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (50.07)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		1.99106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
stallimycin
[no description available]		210
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		2.7430mitomycinalkylating agent;
antineoplastic agent
benzoxazoles
1,3-benzoxazole : A benzoxazole in which the benzene ring is fused to a 1,3-oxazole ring across positions 4 and 5.. benzoxazole : Compounds based on a fused 1,2- or 1,3-oxazole and benzene bicyclic ring skeleton.		3.62901,3-benzoxazoles;
mancude organic heterobicyclic parent
oleanolic acid
[no description available]		2.0710hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
cefoperazone
Cefoperazone: Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It may be used to treat Pseudomonas infections.. cefoperazone : A semi-synthetic parenteral cephalosporin with a tetrazolyl moiety that confers beta-lactamase resistance.		2.0510cephalosporinantibacterial drug
tamoxifen
[no description available]		2.0710stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
b 428
4-iodine-benzo(b)thiophene-2-carboxamidine: structure in first source		2.0710
chromomycin a3
Chromomycin A3: Glycosidic antibiotic from Streptomyces griseus used as a fluorescent stain of DNA and as an antineoplastic agent.		210
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.4620
Cancer of Lung
[description not available]		02.4620
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.4620
Lung Neoplasms
Tumors or cancer of the LUNG.		02.4620