trienomycin-a and Liver-Neoplasms

trienomycin-a has been researched along with Liver-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for trienomycin-a and Liver-Neoplasms

Article	Year
Studies on a novel cytocidal antibiotic, trienomycin A. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. The Journal of antibiotics, 1985, Volume: 38, Issue:6 A new antibiotic, trienomycin A, has been isolated from the culture broth of Streptomyces sp. No. 83-16. The physico-chemical characteristics of the antibiotic suggested that it belongs to the group of ansamycin antibiotics with a triene moiety in the molecule. The molecular formula of trienomycin A is C36H50N2O7 (MW 622). The antibiotic possesses potent cytocidal activity against HeLa S3 and PLC hepatoma cells at concentrations of 0.1 and 0.01 micrograms/ml (IC50 value) respectively. However, trienomycin A showed no antimicrobial activity against the bacteria, fungi and yeasts examined with the exception of weak activity versus Piricularia oryzae at a concentration of 1,000 micrograms/ml. Topics: Alanine; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line; Chemical Phenomena; Chemistry; Fermentation; HeLa Cells; Humans; Liver Neoplasms; Streptomyces	1985

Article

Year

Studies on a novel cytocidal antibiotic, trienomycin A. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.

The Journal of antibiotics, 1985, Volume: 38, Issue:6

A new antibiotic, trienomycin A, has been isolated from the culture broth of Streptomyces sp. No. 83-16. The physico-chemical characteristics of the antibiotic suggested that it belongs to the group of ansamycin antibiotics with a triene moiety in the molecule. The molecular formula of trienomycin A is C36H50N2O7 (MW 622). The antibiotic possesses potent cytocidal activity against HeLa S3 and PLC hepatoma cells at concentrations of 0.1 and 0.01 micrograms/ml (IC50 value) respectively. However, trienomycin A showed no antimicrobial activity against the bacteria, fungi and yeasts examined with the exception of weak activity versus Piricularia oryzae at a concentration of 1,000 micrograms/ml.

Topics: Alanine; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line; Chemical Phenomena; Chemistry; Fermentation; HeLa Cells; Humans; Liver Neoplasms; Streptomyces

1985