sodium-aescinate and Acute-Kidney-Injury

Drug-induced nephrotoxicity is potentially lethal. When sodium aescinate is given to surgical inpatients to treat postoperative inflammation and oedema, adverse drug reactions and drug-drug interactions must be closely monitored.. We report a case of a 58-year-old man with phalangeal fractures who suffered from acute kidney injury that was most likely induced by the drug interaction between sodium aescinate and ginkgo biloba extract due to the protein-binding and metabolic characteristics of these drugs.. Close monitoring and the prompt discontinuation of drugs that have high protein-binding capacity and hepatic metabolism are necessary to avoid drug-drug interactions in patients who are treated with sodium aescinate.

Topics: Acute Kidney Injury; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Ginkgo biloba; Herb-Drug Interactions; Humans; Male; Middle Aged; Plant Extracts; Protein Binding; Saponins; Triterpenes