sodium-aescinate and Carcinogenesis

Primary hepatocellular carcinoma (HCC) is a very malignant tumor in the world. CARMA3 plays an oncogenic role in the pathogenesis of various tumors. However, the function of CARMA3 in HCC has not been fully clarified.. To study the biological function of CAEMA3 in HCC.. Tissue microarray slides including tissues form 100 HCC patients were applied to access the expression of CARMA3 in HCC and its clinical relevance. Knockdown and overexpression of CARMA3 were conducted with plasmid transfection. MTT, colony formation, and apoptosis assays were performed to check the biological activity of cells.. Overexpression of CARMA3 in HCC tissues correlates with a poor prognosis in HCC patients. CARMA3 acts pro-tumorigenic effects partly through activation of CARMA3/NF-κB. SA inhibits HCC growth by targeting CARMA3/NF-κB.

Topics: Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; CARD Signaling Adaptor Proteins; Cell Line, Tumor; Cell Proliferation; Disease-Free Survival; Down-Regulation; Drug Screening Assays, Antitumor; Female; Follow-Up Studies; Gene Expression Profiling; Gene Knockdown Techniques; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; NF-kappa B; Prognosis; Saponins; Signal Transduction; Tissue Array Analysis; Triterpenes