Page last updated: 2024-12-11
salannin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
salannin: from seeds of neem tree, Azadirachta indica; inhibits 20-monooxygenase; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
salannin : A limonoid with insecticidal activity isolated from Azadirachta indica. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Related Flora
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Azadirachta | genus | A plant genus of the family MELIACEAE. Members contain azadirachtin A (a limonoid commonly referred to as azadirachtin) and other TRITERPENES. They have been used in PESTICIDES. The old name of Melia azadirachta is very similar to a related plant, MELIA AZEDARACH.[MeSH] | Meliaceae | The mahogany plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida.[MeSH] |
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 6437066 |
| CHEMBL ID | 3823041 |
| CHEBI ID | 67309 |
| SCHEMBL ID | 19588463 |
| MeSH ID | M0275946 |
Synonyms (21)
| Synonym |
|---|
| 992-20-1 |
| salannin |
| CHEBI:67309 |
| (2ar,3r,5s,5ar,6r,6ar,8r,9ar,10as,10br,10cr)-3-(acetyloxy)-8-(furan-3-yl)-6-(2-methoxy-2-oxoethyl)-2a,5a,6a,7-tetramethyl-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-2h,3h-cyclopenta[d]naphtho[2,3-b:1,8-b'c']difuran-5-yl (2e)-2-methylbut-2-enoate |
| bdbm92411 |
| azadirachtin, neem |
| caswell no. 594a |
| azadriactin |
| 2h,3h-cyclopenta(d')naphtho(1,8-bc:2,3-b')difuran-6-acetic acid, 3-(acetyloxy)-8-(3-furanyl)-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-2a,5a,6a,7-tetramethyl-5-(((2e)-2-methyl-1-oxo-2-butenyl)oxy)-, methyl ester, (2ar,3r,5s,5ar,6r,6ar,8r,9ar,10as,10br |
| 2h,3h-cyclopenta(d')naphtho(1,8-bc:2,3-b')difuran-6-acetic acid, 3-(acetyloxy)-8-(3-furanyl)-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-2a,5a,6a,7-tetramethyl-5-((2-methyl-1-oxo-2-butenyl)oxy)-, methyl ester, (2aalpha,3beta,5beta(e), 5aalpha,6alpha,6aa |
| DTXSID6058500 |
| CHEMBL3823041 |
| SCHEMBL19588463 |
| salannin(p) |
| [(1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-14-acetyloxy-6-(furan-3-yl)-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.02,9.04,8.015,18]octadec-7-en-12-yl] (e)-2-methylbut-2-enoate |
| Q27104942 |
| HY-123026 |
| margosan-o; azadriactin |
| CS-0079900 |
| MS-30583 |
| AKOS040753900 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Roles (3)
| Role | Description |
|---|---|
| insect growth regulator | A growth regulator that inhibits the life cycle of an insect. |
| antifeedant | A substance that prevents pests from feeding. |
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Drug Classes (5)
| Class | Description |
|---|---|
| acetate ester | Any carboxylic ester where the carboxylic acid component is acetic acid. |
| furans | Compounds containing at least one furan ring. |
| limonoid | Any triterpenoid that is highly oxygenated and has a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. The term 'limonoid' comes from limonin, the first tetranortriterpenoid obtained from citrus bitter principles. |
| organic heteropentacyclic compound | |
| methyl ester | Any carboxylic ester resulting from the formal condensation of a carboxy group with methanol. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 (µMol) | 90.0000 | 0.0380 | 3.0910 | 9.8000 | AID1799767 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (35)
Molecular Functions (8)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| protease binding | Macrophage migration inhibitory factor | Homo sapiens (human) |
| dopachrome isomerase activity | Macrophage migration inhibitory factor | Homo sapiens (human) |
| cytokine activity | Macrophage migration inhibitory factor | Homo sapiens (human) |
| cytokine receptor binding | Macrophage migration inhibitory factor | Homo sapiens (human) |
| protein binding | Macrophage migration inhibitory factor | Homo sapiens (human) |
| chemoattractant activity | Macrophage migration inhibitory factor | Homo sapiens (human) |
| identical protein binding | Macrophage migration inhibitory factor | Homo sapiens (human) |
| phenylpyruvate tautomerase activity | Macrophage migration inhibitory factor | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Ceullar Components (11)
Bioassays (2)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1799767 | Tautomerase Activity Assay from Article 10.1074/jbc.M112.341321: \\Novel Anti-inflammatory Activity of Epoxyazadiradione against Macrophage Migration Inhibitory Factor: INHIBITION OF TAUTOMERASE AND PROINFLAMMATORY ACTIVITIES OF MACROPHAGE MIGRATION INHIBI | 2012 | The Journal of biological chemistry, Jul-13, Volume: 287, Issue:29 | Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor. |
| AID1311321 | Osteogenic activity in rat primary calvarial osteoblasts at 1 pM after 48 hrs by ALP-based colorimetric assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (14)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 31.23
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (31.23) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||