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azadirachtin b

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Description

azadirachtin B: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

azadirachtin B : A member of the class of azadirachtin found in the neem tree, Azadirachta indica. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID21725521
CHEMBL ID451665
MeSH IDM0452894

Synonyms (18)

Synonym
azadirachtin b
CHEMBL451665
3-tigloyl-azadirachtol
x5t1rmz28i ,
azadirachtinol deacetyl
unii-x5t1rmz28i
deacetylazadirachtinol
106500-25-8
azadirachtinb(p)
3-tigloylazadirachtol
USRBWQQLHKQWAV-ZGKQVQOISA-N
HY-133108
azadirachtin b(sh)
CS-0111109
MS-31025
dimethyl (2ar,2a1r,3s,4s,4ar,5s,7as,8s,10r,10as)-3,8-dihydroxy-4-((1ar,2s,3as,6as,7s,7as)-6a-hydroxy-7a-methyl-3a,6a,7,7a-tetrahydro-2,7-methanofuro[2,3-b]oxireno[2,3-e]oxepin-1a(2h)-yl)-4-methyl-10-(((e)-2-methylbut-2-enoyl)oxy)octahydro-1h,7h-naphtho[1,
dimethyl (1s,4s,5r,6s,7s,8r,11s,12r,14s,15r)-7,14-dihydroxy-6-[(1s,2s,6s,8s,9r,11s)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo[6.3.1.02,6.09,11]dodec-3-en-9-yl]-6-methyl-12-[(e)-2-methylbut-2-enoyl]oxy-3,9-dioxatetracyclo[6.6.1.01,5.011,15]pentadecane-4,
AKOS040741190
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID595611Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Apr-25, Volume: 74, Issue:4
Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem).
AID1311324Induction of mineralization in rat primary calvarial osteoblasts assessed as mineralized nodule formation at 0.001 to 10 nM after 12 days by alizarin red S-staining based assay relative to control2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo.
AID1102400Fungicidal activity against Rhizoctonia solani assessed as mycelial growth inhibition2003Journal of agricultural and food chemistry, Jul-02, Volume: 51, Issue:14
An efficient method for the purification and characterization of nematicidal azadirachtins A, B, and H, using MPLC and ESIMS.
AID1311327Upregulation of ALP mRNA expression in rat primary calvarial osteoblasts at 100 pM by RT-PCR analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo.
AID595613Cytotoxicity against human CRL1579 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Apr-25, Volume: 74, Issue:4
Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem).
AID1102397Fungicidal activity against Athelia rolfsii assessed as mycelial growth inhibition2003Journal of agricultural and food chemistry, Jul-02, Volume: 51, Issue:14
An efficient method for the purification and characterization of nematicidal azadirachtins A, B, and H, using MPLC and ESIMS.
AID402679Toxicity in Plutella xylostella larvae after 72 hrs2005Journal of natural products, Jul, Volume: 68, Issue:7
Azadirachtin derivatives from seed kernels of Azadirachta excelsa.
AID1311329Upregulation of ALP mRNA expression in rat primary calvarial osteoblasts at 10 nM and 100 pM by RT-PCR analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo.
AID402680Toxicity in Plutella xylostella larvae after 96 hrs2005Journal of natural products, Jul, Volume: 68, Issue:7
Azadirachtin derivatives from seed kernels of Azadirachta excelsa.
AID402677Toxicity in Plutella xylostella larvae after 24 hrs2005Journal of natural products, Jul, Volume: 68, Issue:7
Azadirachtin derivatives from seed kernels of Azadirachta excelsa.
AID1311328Upregulation of RunX-2 mRNA expression in rat primary calvarial osteoblasts at 10 nM by RT-PCR analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo.
AID402678Toxicity in Plutella xylostella larvae after 48 hrs2005Journal of natural products, Jul, Volume: 68, Issue:7
Azadirachtin derivatives from seed kernels of Azadirachta excelsa.
AID595610Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Apr-25, Volume: 74, Issue:4
Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem).
AID595612Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Apr-25, Volume: 74, Issue:4
Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem).
AID1311320Osteogenic activity in rat primary calvarial osteoblasts at 100 pM after 48 hrs by ALP-based colorimetric assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo.
AID595609Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Apr-25, Volume: 74, Issue:4
Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem).
AID1311330Upregulation of OCN mRNA expression in rat primary calvarial osteoblasts at 10 nM by RT-PCR analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo.
AID1102403Nematicidal activity against fourth-stage juvenile of Rotylenchulus reniformis (reniform nematode) assessed as juvenile immobility after 72 hr by stereoscopic binocular microscopic analysis2003Journal of agricultural and food chemistry, Jul-02, Volume: 51, Issue:14
An efficient method for the purification and characterization of nematicidal azadirachtins A, B, and H, using MPLC and ESIMS.
AID1311322Induction of cell proliferation in rat primary calvarial osteoblasts at 0.1 to 10 nM after 48 hrs by BrDU-staining based assay relative to control2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo.
AID1102408Nematicidal activity against Caenorhabditis elegans assessed as mortality at 200 ppm after 24 hr2003Journal of agricultural and food chemistry, Jul-02, Volume: 51, Issue:14
An efficient method for the purification and characterization of nematicidal azadirachtins A, B, and H, using MPLC and ESIMS.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (54.55)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]