safrole oxide has been researched along with safrole in 24 studies
*Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA). [MeSH]
*Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA). [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 11 (45.83) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Akamatsu, K; Watabe, T | 1 |
| Miller, EC; Miller, JA; Swanson, AB | 1 |
| Guenthner, TM; Qato, MK | 1 |
| Guenthner, TM; Luo, G | 1 |
| Du, CQ; Li, HH; Miao, JY; Zhang, SL; Zhao, BX | 1 |
| Du, AY; Du, CQ; Miao, JY; Zhao, BX; Zhao, KW | 1 |
| Du, A; Miao, J; Zhang, S; Zhao, B | 1 |
| Miao, J; Yin, D; Zhang, S; Zhao, B; Zhao, J | 2 |
| Miao, J; Zhang, S; Zhao, B; Zhao, J | 1 |
| Du, A; Miao, J; Yin, D; Zhang, S; Zhao, B | 2 |
| Miao, JY; Su, L; Yin, DL; Zhang, SL; Zhao, BX; Zhao, J | 1 |
| Lv, X; Miao, J; Su, L; Wang, N; Zhang, S; Zhao, B; Zhao, J | 1 |
| Lv, X; Miao, J; Su, L; Zhang, S; Zhao, B; Zhao, J | 1 |
| Miao, JY; Su, L; Zhang, SL; Zhao, BX; Zhao, J | 1 |
| Chiang, SY; Chung, WS; Huang, HF; Lai, MT; Lee, PY; Shen, LC; Wu, HC; Wu, KY | 1 |
| Chiang, SY; Chung, WS; Lin, MH; Shen, LC; Wu, KY | 1 |
| Su, L; Sun, C; Xin, J; Zhao, B; Zhao, J; Zhao, Y | 1 |
| Miao, J; Su, L; Zhang, H; Zhang, S; Zhang, Y; Zhao, B; Zhao, J | 1 |
| Ge, D; Jing, Q; Su, L; Yue, H; Zhang, S; Zhao, J; Zhao, W | 1 |
| Aguado, JM; Aguirregabiria, M; Benítez, RM; Berbel, D; Boix-Palop, L; Calbo, E; Carratala, J; Cobo, S; Cuervo, G; Domínguez, MÁ; Euba, G; Garcia-Pais, MJ; Garcia-Pardo, G; Gasch, O; Gioia, F; Gomez-Zorrilla, S; Gomila-Grange, A; Grillo, S; Hereu, P; Horna, G; Iftimie, S; Jover-Sáenz, A; Loeches-Yagüe, MB; López-Contreras, J; López-Cortés, LE; Meije, Y; Miro, JM; Morata, L; Oriol, I; Padullés, A; Pallarés, N; Paño, JR; Pedro-Botet, ML; Pérez-Rodríguez, MT; Pujol, M; San-Juan, R; Tebe, C; Videla, S | 1 |
| Han, X; Li, K; Miao, J; Su, L; Sun, C; Zhao, B; Zhao, Y | 1 |
| Chang, BS; Chen, YY; Chiang, SY; Chung, WS; Huang, HF; Huang, YC; Luo, YS; Shen, LC; Wei, YT; Wu, KY | 1 |
1 trial(s) available for safrole oxide and safrole
| Article | Year |
|---|---|
Multicentre, randomised, open-label, phase IV-III study to evaluate the efficacy of cloxacillin plus fosfomycin versus cloxacillin alone in adult patients with methicillin-susceptible
Topics: Adult; Bacteremia; Cloxacillin; Fosfomycin; Humans; Methicillin; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Safrole; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome | 2021 |
23 other study(ies) available for safrole oxide and safrole
| Article | Year |
|---|---|
Photometric assay of hepatic epoxide hydrolase activity with safrole oxide (SAFO) as substrate.
Topics: Animals; Chromatography, Gas; Chromatography, Thin Layer; Dioxoles; Epoxy Compounds; Glycols; Hydro-Lyases; In Vitro Techniques; Liver; Mass Spectrometry; Methods; Microsomes, Liver; Photometry; Rabbits; Safrole; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Time Factors | 1974 |
The side-chain epoxidation and hydroxylation of the hepatocarcinogens safrole and estragole and some related compounds by rat and mouse liver microsomes.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; Dioxoles; Epoxy Compounds; Flavoring Agents; Hydroxylation; Mice; Microsomes, Liver; Rats; Safrole; Species Specificity; Structure-Activity Relationship | 1981 |
32P-postlabeling analysis of adducts formed between DNA and safrole 2',3'-epoxide: absence of adduct formation in vivo.
Topics: Animals; DNA Adducts; Liver; Male; Mice; Mice, Inbred BALB C; Phosphorus Radioisotopes; Safrole | 1995 |
Covalent binding to DNA in vitro of 2',3'-oxides derived from allylbenzene analogs.
Topics: Animals; Anisoles; Benzene Derivatives; Deoxyguanosine; DNA; DNA Adducts; Epoxide Hydrolases; Epoxy Compounds; Guanosine; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Safrole | 1996 |
Effect of safrole oxide on vascular endothelial cell growth and apoptosis induced by deprivation of fibroblast growth factor.
Topics: Apoptosis; Cell Division; Cells, Cultured; DNA Fragmentation; Drug Interactions; Endothelium, Vascular; Fibroblast Growth Factors; Humans; Safrole; Umbilical Veins | 2002 |
Effects of novel safrole oxide derivatives, 1-methoxy-3-(3,4-methylenedioxyphenyl)-2-propanol and 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, on apoptosis induced by deprivation of survival factors in vascular endothelial cells.
Topics: Apoptosis; Cell Division; Cell Nucleus; Cells, Cultured; DNA Fragmentation; Endothelium, Vascular; Fibroblast Growth Factors; Flow Cytometry; Humans; Interphase; Safrole; Serum; Umbilical Veins | 2003 |
Safrole oxide induces apoptosis in A549 human lung cancer cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Humans; L-Lactate Dehydrogenase; Lung Neoplasms; ras Proteins; Safrole; Tumor Suppressor Protein p53 | 2004 |
Safrole oxide inhibits angiogenesis by inducing apoptosis.
Topics: Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Apoptosis; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Collagen; DNA; DNA Fragmentation; In Vitro Techniques; Male; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Safrole; Sepharose | 2005 |
Upregulating of Fas, integrin beta4 and P53 and depressing of PC-PLC activity and ROS level in VEC apoptosis by safrole oxide.
Topics: Apoptosis; Down-Regulation; Endothelial Cells; Endothelium, Vascular; fas Receptor; Humans; Integrin beta4; Nitric Oxide Synthase; Reactive Oxygen Species; Safrole; Tumor Suppressor Protein p53; Type C Phospholipases; Up-Regulation | 2005 |
Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspases; Cell Line, Tumor; Chemistry, Pharmaceutical; Colorimetry; Drug Design; Humans; Inflammation; Lung Neoplasms; Models, Chemical; Safrole; Time Factors; Up-Regulation | 2006 |
Safrole oxide induces apoptosis by up-regulating Fas and FasL instead of integrin beta4 in A549 human lung cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Humans; Integrin beta4; Lung Neoplasms; Membrane Glycoproteins; Receptors, Tumor Necrosis Factor; Safrole; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Necrosis Factors; Tumor Suppressor Protein p53; Up-Regulation | 2006 |
Safrole oxide induced human umbilical vein vascular endothelial cell differentiation into neuron-like cells by depressing the reactive oxygen species level at the low concentration.
Topics: Blotting, Western; Carrier Proteins; Cell Differentiation; Cell Survival; Cells, Cultured; Endothelial Cells; Eukaryotic Initiation Factors; fas Receptor; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Intermediate Filament Proteins; Neurons; Nitric Oxide Synthase; Reactive Oxygen Species; Safrole; Time Factors; Umbilical Veins | 2006 |
Suppressing Akt phosphorylation and activating Fas by safrole oxide inhibited angiogenesis and induced vascular endothelial cell apoptosis in the presence of fibroblast growth factor-2 and serum.
Topics: Animals; Apoptosis; DNA Fragmentation; Endothelium, Vascular; fas Receptor; Fibroblast Growth Factor 2; Humans; Neovascularization, Physiologic; Nitric Oxide Synthase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Safrole; Serum; Tumor Suppressor Protein p53; Type C Phospholipases | 2006 |
Safrole oxide induces neuronal apoptosis through inhibition of integrin beta4/SOD activity and elevation of ROS/NADPH oxidase activity.
Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Situ Nick-End Labeling; Integrin beta4; Mice; NADPH Oxidases; Neurons; Reactive Oxygen Species; Safrole; Superoxide Dismutase | 2007 |
Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
Topics: Animals; Apoptosis; Cell Communication; Cell Differentiation; Cell Survival; Coculture Techniques; Embryonic Stem Cells; Endothelium, Vascular; Mice; Neurons; Safrole | 2007 |
Safrole oxide induces human umbilical vein endothelial cell transdifferentiation to 5-hydroxytryptaminergic neuron-like cells through tropomyosin receptor kinase A/cyclooxygenase 2/nuclear factor-kappa B/interleukin 8 signaling.
Topics: Apoptosis; Calcium; Cell Survival; Cell Transdifferentiation; Cyclooxygenase 2; Endothelial Cells; Gene Expression Profiling; Human Umbilical Vein Endothelial Cells; Humans; Interleukin-8; Metabolic Networks and Pathways; Neurons; NF-kappa B; Protein Kinases; Reactive Oxygen Species; Safrole; Serotonin; Tropomyosin; Umbilical Veins | 2011 |
Safrole-2',3'-oxide induces cytotoxic and genotoxic effects in HepG2 cells and in mice.
Topics: Animals; Comet Assay; DNA Damage; Hep G2 Cells; Humans; Leukocytes; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagens; Safrole | 2011 |
In vivo formation of N7-guanine DNA adduct by safrole 2',3'-oxide in mice.
Topics: Animals; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Guanine; Indicator Dilution Techniques; Limit of Detection; Magnetic Resonance Spectroscopy; Male; Mice; Safrole; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
Safrole oxide induced neuronal differentiation of rat bone-marrow mesenchymal stem cells by elevating Hsp70.
Topics: Animals; Base Sequence; Bone Marrow Cells; Cell Differentiation; Cell Survival; Gene Knockdown Techniques; Glial Fibrillary Acidic Protein; HSP70 Heat-Shock Proteins; In Vitro Techniques; Mesenchymal Stem Cells; Neurofilament Proteins; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Wistar; RNA, Messenger; RNA, Small Interfering; Safrole | 2012 |
Safrole-2',3'-oxide induces atherosclerotic plaque vulnerability in apolipoprotein E-knockout mice.
Topics: Animals; Apolipoproteins E; Apoptosis; Cholesterol; Endothelium, Vascular; Histocytochemistry; Interleukin-8; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Receptors, Nerve Growth Factor; Safrole; Triglycerides | 2013 |
Finding ATF4/p75NTR/IL-8 signal pathway in endothelial-mesenchymal transition by safrole oxide.
Topics: Activating Transcription Factor 4; Fibrosis; Gene Expression Regulation; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Interleukin-8; Neoplasms; Nerve Tissue Proteins; Receptors, Nerve Growth Factor; Safrole; Signal Transduction | 2014 |
Safrole oxide induced 5-HT neuron-like cell differentiation of bone marrow mesenchymal stem cells by elevating G9a.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Histone Methyltransferases; Mesenchymal Stem Cells; Neurons; RNA, Small Interfering; Safrole; Serotonin | 2022 |
Dose-response formation of N7-(3-benzo[1,3]dioxol-5-yl-2-hydroxypropyl)guanine in liver and urine correlates with micronucleated reticulocyte frequencies in mice administered safrole oxide.
Topics: Animals; Chromatography, High Pressure Liquid; DNA Adducts; Guanine; Liver; Mice; Reticulocytes; Safrole; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2023 |