Page last updated: 2024-08-26

safrole oxide and safrole

safrole oxide has been researched along with safrole in 24 studies

*Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA). [MeSH]

*Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA). [MeSH]

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.33)18.7374
1990's2 (8.33)18.2507
2000's11 (45.83)29.6817
2010's6 (25.00)24.3611
2020's3 (12.50)2.80

Authors

AuthorsStudies
Akamatsu, K; Watabe, T1
Miller, EC; Miller, JA; Swanson, AB1
Guenthner, TM; Qato, MK1
Guenthner, TM; Luo, G1
Du, CQ; Li, HH; Miao, JY; Zhang, SL; Zhao, BX1
Du, AY; Du, CQ; Miao, JY; Zhao, BX; Zhao, KW1
Du, A; Miao, J; Zhang, S; Zhao, B1
Miao, J; Yin, D; Zhang, S; Zhao, B; Zhao, J2
Miao, J; Zhang, S; Zhao, B; Zhao, J1
Du, A; Miao, J; Yin, D; Zhang, S; Zhao, B2
Miao, JY; Su, L; Yin, DL; Zhang, SL; Zhao, BX; Zhao, J1
Lv, X; Miao, J; Su, L; Wang, N; Zhang, S; Zhao, B; Zhao, J1
Lv, X; Miao, J; Su, L; Zhang, S; Zhao, B; Zhao, J1
Miao, JY; Su, L; Zhang, SL; Zhao, BX; Zhao, J1
Chiang, SY; Chung, WS; Huang, HF; Lai, MT; Lee, PY; Shen, LC; Wu, HC; Wu, KY1
Chiang, SY; Chung, WS; Lin, MH; Shen, LC; Wu, KY1
Su, L; Sun, C; Xin, J; Zhao, B; Zhao, J; Zhao, Y1
Miao, J; Su, L; Zhang, H; Zhang, S; Zhang, Y; Zhao, B; Zhao, J1
Ge, D; Jing, Q; Su, L; Yue, H; Zhang, S; Zhao, J; Zhao, W1
Aguado, JM; Aguirregabiria, M; Benítez, RM; Berbel, D; Boix-Palop, L; Calbo, E; Carratala, J; Cobo, S; Cuervo, G; Domínguez, MÁ; Euba, G; Garcia-Pais, MJ; Garcia-Pardo, G; Gasch, O; Gioia, F; Gomez-Zorrilla, S; Gomila-Grange, A; Grillo, S; Hereu, P; Horna, G; Iftimie, S; Jover-Sáenz, A; Loeches-Yagüe, MB; López-Contreras, J; López-Cortés, LE; Meije, Y; Miro, JM; Morata, L; Oriol, I; Padullés, A; Pallarés, N; Paño, JR; Pedro-Botet, ML; Pérez-Rodríguez, MT; Pujol, M; San-Juan, R; Tebe, C; Videla, S1
Han, X; Li, K; Miao, J; Su, L; Sun, C; Zhao, B; Zhao, Y1
Chang, BS; Chen, YY; Chiang, SY; Chung, WS; Huang, HF; Huang, YC; Luo, YS; Shen, LC; Wei, YT; Wu, KY1

Trials

1 trial(s) available for safrole oxide and safrole

ArticleYear
Multicentre, randomised, open-label, phase IV-III study to evaluate the efficacy of cloxacillin plus fosfomycin versus cloxacillin alone in adult patients with methicillin-susceptible
    BMJ open, 2021, 08-05, Volume: 11, Issue:8

    Topics: Adult; Bacteremia; Cloxacillin; Fosfomycin; Humans; Methicillin; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Safrole; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome

2021

Other Studies

23 other study(ies) available for safrole oxide and safrole

ArticleYear
Photometric assay of hepatic epoxide hydrolase activity with safrole oxide (SAFO) as substrate.
    Biochemical pharmacology, 1974, Oct-15, Volume: 23, Issue:20

    Topics: Animals; Chromatography, Gas; Chromatography, Thin Layer; Dioxoles; Epoxy Compounds; Glycols; Hydro-Lyases; In Vitro Techniques; Liver; Mass Spectrometry; Methods; Microsomes, Liver; Photometry; Rabbits; Safrole; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Time Factors

1974
The side-chain epoxidation and hydroxylation of the hepatocarcinogens safrole and estragole and some related compounds by rat and mouse liver microsomes.
    Biochimica et biophysica acta, 1981, Apr-03, Volume: 673, Issue:4

    Topics: Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; Dioxoles; Epoxy Compounds; Flavoring Agents; Hydroxylation; Mice; Microsomes, Liver; Rats; Safrole; Species Specificity; Structure-Activity Relationship

1981
32P-postlabeling analysis of adducts formed between DNA and safrole 2',3'-epoxide: absence of adduct formation in vivo.
    Toxicology letters, 1995, Volume: 75, Issue:1-3

    Topics: Animals; DNA Adducts; Liver; Male; Mice; Mice, Inbred BALB C; Phosphorus Radioisotopes; Safrole

1995
Covalent binding to DNA in vitro of 2',3'-oxides derived from allylbenzene analogs.
    Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:9

    Topics: Animals; Anisoles; Benzene Derivatives; Deoxyguanosine; DNA; DNA Adducts; Epoxide Hydrolases; Epoxy Compounds; Guanosine; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Safrole

1996
Effect of safrole oxide on vascular endothelial cell growth and apoptosis induced by deprivation of fibroblast growth factor.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:4

    Topics: Apoptosis; Cell Division; Cells, Cultured; DNA Fragmentation; Drug Interactions; Endothelium, Vascular; Fibroblast Growth Factors; Humans; Safrole; Umbilical Veins

2002
Effects of novel safrole oxide derivatives, 1-methoxy-3-(3,4-methylenedioxyphenyl)-2-propanol and 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, on apoptosis induced by deprivation of survival factors in vascular endothelial cells.
    Vascular pharmacology, 2003, Volume: 40, Issue:3

    Topics: Apoptosis; Cell Division; Cell Nucleus; Cells, Cultured; DNA Fragmentation; Endothelium, Vascular; Fibroblast Growth Factors; Flow Cytometry; Humans; Interphase; Safrole; Serum; Umbilical Veins

2003
Safrole oxide induces apoptosis in A549 human lung cancer cells.
    Experimental lung research, 2004, Volume: 30, Issue:6

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Humans; L-Lactate Dehydrogenase; Lung Neoplasms; ras Proteins; Safrole; Tumor Suppressor Protein p53

2004
Safrole oxide inhibits angiogenesis by inducing apoptosis.
    Vascular pharmacology, 2005, Volume: 43, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Apoptosis; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Collagen; DNA; DNA Fragmentation; In Vitro Techniques; Male; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Safrole; Sepharose

2005
Upregulating of Fas, integrin beta4 and P53 and depressing of PC-PLC activity and ROS level in VEC apoptosis by safrole oxide.
    FEBS letters, 2005, Oct-24, Volume: 579, Issue:25

    Topics: Apoptosis; Down-Regulation; Endothelial Cells; Endothelium, Vascular; fas Receptor; Humans; Integrin beta4; Nitric Oxide Synthase; Reactive Oxygen Species; Safrole; Tumor Suppressor Protein p53; Type C Phospholipases; Up-Regulation

2005
Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.
    Bioorganic & medicinal chemistry letters, 2006, Jan-01, Volume: 16, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspases; Cell Line, Tumor; Chemistry, Pharmaceutical; Colorimetry; Drug Design; Humans; Inflammation; Lung Neoplasms; Models, Chemical; Safrole; Time Factors; Up-Regulation

2006
Safrole oxide induces apoptosis by up-regulating Fas and FasL instead of integrin beta4 in A549 human lung cancer cells.
    Bioorganic & medicinal chemistry, 2006, Apr-01, Volume: 14, Issue:7

    Topics: Apoptosis; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Humans; Integrin beta4; Lung Neoplasms; Membrane Glycoproteins; Receptors, Tumor Necrosis Factor; Safrole; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Necrosis Factors; Tumor Suppressor Protein p53; Up-Regulation

2006
Safrole oxide induced human umbilical vein vascular endothelial cell differentiation into neuron-like cells by depressing the reactive oxygen species level at the low concentration.
    Biochimica et biophysica acta, 2006, Volume: 1763, Issue:2

    Topics: Blotting, Western; Carrier Proteins; Cell Differentiation; Cell Survival; Cells, Cultured; Endothelial Cells; Eukaryotic Initiation Factors; fas Receptor; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Intermediate Filament Proteins; Neurons; Nitric Oxide Synthase; Reactive Oxygen Species; Safrole; Time Factors; Umbilical Veins

2006
Suppressing Akt phosphorylation and activating Fas by safrole oxide inhibited angiogenesis and induced vascular endothelial cell apoptosis in the presence of fibroblast growth factor-2 and serum.
    The international journal of biochemistry & cell biology, 2006, Volume: 38, Issue:9

    Topics: Animals; Apoptosis; DNA Fragmentation; Endothelium, Vascular; fas Receptor; Fibroblast Growth Factor 2; Humans; Neovascularization, Physiologic; Nitric Oxide Synthase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Safrole; Serum; Tumor Suppressor Protein p53; Type C Phospholipases

2006
Safrole oxide induces neuronal apoptosis through inhibition of integrin beta4/SOD activity and elevation of ROS/NADPH oxidase activity.
    Life sciences, 2007, Feb-20, Volume: 80, Issue:11

    Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Situ Nick-End Labeling; Integrin beta4; Mice; NADPH Oxidases; Neurons; Reactive Oxygen Species; Safrole; Superoxide Dismutase

2007
Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
    Bioorganic & medicinal chemistry letters, 2007, Jun-01, Volume: 17, Issue:11

    Topics: Animals; Apoptosis; Cell Communication; Cell Differentiation; Cell Survival; Coculture Techniques; Embryonic Stem Cells; Endothelium, Vascular; Mice; Neurons; Safrole

2007
Safrole oxide induces human umbilical vein endothelial cell transdifferentiation to 5-hydroxytryptaminergic neuron-like cells through tropomyosin receptor kinase A/cyclooxygenase 2/nuclear factor-kappa B/interleukin 8 signaling.
    The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:10

    Topics: Apoptosis; Calcium; Cell Survival; Cell Transdifferentiation; Cyclooxygenase 2; Endothelial Cells; Gene Expression Profiling; Human Umbilical Vein Endothelial Cells; Humans; Interleukin-8; Metabolic Networks and Pathways; Neurons; NF-kappa B; Protein Kinases; Reactive Oxygen Species; Safrole; Serotonin; Tropomyosin; Umbilical Veins

2011
Safrole-2',3'-oxide induces cytotoxic and genotoxic effects in HepG2 cells and in mice.
    Mutation research, 2011, Dec-24, Volume: 726, Issue:2

    Topics: Animals; Comet Assay; DNA Damage; Hep G2 Cells; Humans; Leukocytes; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagens; Safrole

2011
In vivo formation of N7-guanine DNA adduct by safrole 2',3'-oxide in mice.
    Toxicology letters, 2012, Sep-18, Volume: 213, Issue:3

    Topics: Animals; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Guanine; Indicator Dilution Techniques; Limit of Detection; Magnetic Resonance Spectroscopy; Male; Mice; Safrole; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2012
Safrole oxide induced neuronal differentiation of rat bone-marrow mesenchymal stem cells by elevating Hsp70.
    Gene, 2012, Nov-01, Volume: 509, Issue:1

    Topics: Animals; Base Sequence; Bone Marrow Cells; Cell Differentiation; Cell Survival; Gene Knockdown Techniques; Glial Fibrillary Acidic Protein; HSP70 Heat-Shock Proteins; In Vitro Techniques; Mesenchymal Stem Cells; Neurofilament Proteins; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Wistar; RNA, Messenger; RNA, Small Interfering; Safrole

2012
Safrole-2',3'-oxide induces atherosclerotic plaque vulnerability in apolipoprotein E-knockout mice.
    Toxicology letters, 2013, Feb-27, Volume: 217, Issue:2

    Topics: Animals; Apolipoproteins E; Apoptosis; Cholesterol; Endothelium, Vascular; Histocytochemistry; Interleukin-8; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Receptors, Nerve Growth Factor; Safrole; Triglycerides

2013
Finding ATF4/p75NTR/IL-8 signal pathway in endothelial-mesenchymal transition by safrole oxide.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Activating Transcription Factor 4; Fibrosis; Gene Expression Regulation; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Interleukin-8; Neoplasms; Nerve Tissue Proteins; Receptors, Nerve Growth Factor; Safrole; Signal Transduction

2014
Safrole oxide induced 5-HT neuron-like cell differentiation of bone marrow mesenchymal stem cells by elevating G9a.
    In vitro cellular & developmental biology. Animal, 2022, Volume: 58, Issue:7

    Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Histone Methyltransferases; Mesenchymal Stem Cells; Neurons; RNA, Small Interfering; Safrole; Serotonin

2022
Dose-response formation of N7-(3-benzo[1,3]dioxol-5-yl-2-hydroxypropyl)guanine in liver and urine correlates with micronucleated reticulocyte frequencies in mice administered safrole oxide.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023, Volume: 181

    Topics: Animals; Chromatography, High Pressure Liquid; DNA Adducts; Guanine; Liver; Mice; Reticulocytes; Safrole; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2023