rhodomycinone

Description

Rhodomycinone is a potent antitumor antibiotic produced by the bacterium Streptomyces purpurascens. It is known for its complex structure, which includes a highly oxygenated anthraquinone core. The compound exhibits a wide range of biological activities, including cytotoxic activity against several cancer cell lines. Notably, rhodomycinone has shown promising anticancer effects in preclinical studies, with potential applications in treating leukemia, lymphoma, and breast cancer. The synthesis of rhodomycinone remains a significant challenge due to its intricate molecular architecture. Researchers are actively investigating various approaches to synthesizing rhodomycinone, including biocatalytic methods and total synthesis strategies. The understanding of rhodomycinone's biosynthesis and its potential anticancer properties has sparked considerable research interest in the development of new antitumor agents. Studying rhodomycinone is crucial for exploring its therapeutic potential and understanding the mechanisms of action underlying its biological effects. The complex structure of this compound also serves as a fascinating target for synthetic chemistry research, pushing the boundaries of organic synthesis and providing valuable insights into molecular complexity.'

rhodomycinone: anthracycline antibiotic [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

epsilon-rhodomycinone : A carboxylic ester that is the methyl ester of (1R,2R,4S)-2-ethyl-2,4,5,7,12-pentahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]