Page last updated: 2024-10-06

daunorubicin biosynthesis

Proteins (19)

ProteinSynonymsTaxonomy
Carminomycin 4-O-methyltransferase DnrKCOMT; EC 2.1.1.292; Anthracycline 4-O-methyltransferaseStreptomyces peucetius
Aklaviketone reductase DauEEC 1.1.1.362
Daunorubicin-doxorubicin polyketide synthaseStreptomyces peucetius
Daunorubicin-doxorubicin polyketide synthaseStreptomyces peucetius
Daunorubicin-doxorubicin polyketide synthaseStreptomyces peucetius
Daunorubicin-doxorubicin polyketide synthaseStreptomyces peucetius
Daunorubicin-doxorubicin polyketide synthaseStreptomyces peucetius
Daunorubicin-doxorubicin polyketide synthaseStreptomyces peucetius
Aklavinone 12-hydroxylase DnrFEC 1.14.13.180; Aklavinone 11-hydroxylase
Rhodomycin D methylesterase DnrPEC 3.1.1.-; 10-carbomethoxy-13-deoxycarminomycin esterase; 4-O-methylrhodomycin D methylesteraseStreptomyces peucetius
TDP-daunosamine transferase DnrSEC 2.4.1.-; 2,3,6-trideoxy-3-aminohexose transferaseStreptomyces peucetius
Aklanonic acid methyltransferase DauCAAMT; EC 2.1.1.288
Aklanonic acid methyl ester cyclase DauDAAME cyclase; EC 5.5.1.23; Methyl aklanonate cyclase
Rhodomycin D methylesterase DauPEC 3.1.1.-; 10-carbomethoxy-13-deoxycarminomycin esterase; 4-O-methylrhodomycin D methylesterase
Cytochrome P-450 monooxygenase DoxAEC 1.14.13.181; 13-deoxycarminomycin C-13 hydroxylase; 13-deoxydaunorubicin C-13 hydroxylase; 13-dihydrocarminomycin C-13 hydroxylase; 13-dihydrodaunorubicin C-13 hydroxylase
OxygenaseStreptomyces sp.
Anthraquinol monooxygenaseStreptomyces peucetius
Anthracycline acyl carrier protein DpsGStreptomyces peucetius
Polyketide cyclaseStreptomyces peucetius

Compounds (19)

CompoundDescription
hydronium ion
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
methanolA colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
daunorubicinolmain metabolite of daunomycin
carubicinA very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.
13-deoxycarminomycinanthracycline antibiotic active against P-388 murine leukemia; structure given in first source
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
aklavinonefrom Streptomyces galilaeus MA 144-M1, strain 3AR-33; structure in first source
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
thymidine 5'-diphosphatesee also record for thymidine 3',5'-diphosphate, RN 2863-04-9
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
S 383-Y
Malonyl Coenzyme AA coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.
propionyl-coenzyme ARN given refers to parent cpd
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
rhodomycinoneanthracycline antibiotic