| Protein | Synonyms | Taxonomy |
|---|
| Carminomycin 4-O-methyltransferase DnrK | COMT; EC 2.1.1.292; Anthracycline 4-O-methyltransferase | Streptomyces peucetius |
| Aklaviketone reductase DauE | EC 1.1.1.362 | |
| Daunorubicin-doxorubicin polyketide synthase | | Streptomyces peucetius |
| Daunorubicin-doxorubicin polyketide synthase | | Streptomyces peucetius |
| Daunorubicin-doxorubicin polyketide synthase | | Streptomyces peucetius |
| Daunorubicin-doxorubicin polyketide synthase | | Streptomyces peucetius |
| Daunorubicin-doxorubicin polyketide synthase | | Streptomyces peucetius |
| Daunorubicin-doxorubicin polyketide synthase | | Streptomyces peucetius |
| Aklavinone 12-hydroxylase DnrF | EC 1.14.13.180; Aklavinone 11-hydroxylase | |
| Rhodomycin D methylesterase DnrP | EC 3.1.1.-; 10-carbomethoxy-13-deoxycarminomycin esterase; 4-O-methylrhodomycin D methylesterase | Streptomyces peucetius |
| TDP-daunosamine transferase DnrS | EC 2.4.1.-; 2,3,6-trideoxy-3-aminohexose transferase | Streptomyces peucetius |
| Aklanonic acid methyltransferase DauC | AAMT; EC 2.1.1.288 | |
| Aklanonic acid methyl ester cyclase DauD | AAME cyclase; EC 5.5.1.23; Methyl aklanonate cyclase | |
| Rhodomycin D methylesterase DauP | EC 3.1.1.-; 10-carbomethoxy-13-deoxycarminomycin esterase; 4-O-methylrhodomycin D methylesterase | |
| Cytochrome P-450 monooxygenase DoxA | EC 1.14.13.181; 13-deoxycarminomycin C-13 hydroxylase; 13-deoxydaunorubicin C-13 hydroxylase; 13-dihydrocarminomycin C-13 hydroxylase; 13-dihydrodaunorubicin C-13 hydroxylase | |
| Oxygenase | | Streptomyces sp. |
| Anthraquinol monooxygenase | | Streptomyces peucetius |
| Anthracycline acyl carrier protein DpsG | | Streptomyces peucetius |
| Polyketide cyclase | | Streptomyces peucetius |
| Compound | Description |
|---|
| hydronium ion | |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| methanol | A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| daunorubicinol | main metabolite of daunomycin |
| carubicin | A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata. |
| 13-deoxycarminomycin | anthracycline antibiotic active against P-388 murine leukemia; structure given in first source |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| aklavinone | from Streptomyces galilaeus MA 144-M1, strain 3AR-33; structure in first source |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| thymidine 5'-diphosphate | see also record for thymidine 3',5'-diphosphate, RN 2863-04-9 |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| Coenzyme A | |
| S 383-Y | |
| Malonyl Coenzyme A | A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. |
| propionyl-coenzyme A | RN given refers to parent cpd |
| Flavin-Adenine Dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |
| rhodomycinone | anthracycline antibiotic |