Compounds > pyx 2

Page last updated: 2024-10-15

pyx 2

Description

PYX 2: neuropeptide Y receptor antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	16132128
MeSH ID	M0212109

Synonyms (10)

Synonym
l-tyrosine, n-(n2-(n2-(n2-(n-(n-(n-(n2-(n-(n-acetyl-3-((2,6-dichlorophenyl)methyl)-l-tyrosyl)-l-isoleucyl)-l-asparaginyl)-l-leucyl)-l-isoleucyl)-d-threonyl)-l-arginyl)-l-glutaminyl)-l-arginyl)-3-((2,6-dichlorophenyl)methyl)-
ac-tyr-3-(cl2-bzl)-ile-asn-leu-ile-d-thr-arg-gln-arg-tyr-3-(cl2bzl)-nh2
pyx-2
neuropeptide y (27-36) amide, ac-(3-(2,6-dichlorobenzyl)tyrosyl(27,36)-threonyl(32))-
acetyl-27,36-(3-(2,6-dichlorobenzyl)tyr-32-thr)neuropeptide y (27-36) amide
neuropeptide y (27-36) amide, acetyl-(3-(2,6-dichlorobenzyl)tyr(27,36)-thr(32))-
146999-93-1
ac-(3-(2,6-dichlorobenzyl)tyr(27,36)-d-thr(32))-neuropeptide y (27-36) amide
pyx 2
DTXSID50163558

Dosage Studied

Excerpt	Reference
" Furthermore, NPY was without effect on the dose-response curve to ATP in resting conditions."	( Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens. Corsi, M; Palea, S; Ratti, E; Rimland, JM; Trist, DG, 1995)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	7 (87.50)	18.2507
2000's	1 (12.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
benextramine benextramine: RN given refers to parent cpd	1.98	1	0
cystamine [no description available]	1.98	1	0	organic disulfide; primary amino compound	EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor
suramin Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.	1.98	1	0	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	1.98	1	0	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
bibp 3226 BIBP 3226: a selective non-peptide neuropeptide Y Y1 receptor antagonist; structure given in first source; BIBP-3435 is the S-enantiomer	1.98	1	0
neuropeptide y Neuropeptide Y: A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.	3.49	8	0
1229u91 1229U91: a selective neuropeptide Y-Y1 receptor antagonist; structure given in first source	1.99	1	0
neuropeptide y, leu(31)-pro(34)- neuropeptide Y, Leu(31)-Pro(34)-: specific Y1 receptor agonist	1.98	1	0
neuropeptide y (13-36) [no description available]	1.98	1	0
neuropeptide y neuropeptide Y (2-36): antagonizes the inhibitory action of neuropeptide Y in guinea pig trachea	1.99	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	0	2.01	1	0
Hyperphagia Ingestion of a greater than optimal quantity of food.	0	2.4	2	0
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	0	1.98	1	0
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	0	1.98	1	0
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	0	1.98	1	0
Anesthesia A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.	0	2.39	2	0