Compounds > propylhexedrine
Page last updated: 2024-12-05

propylhexedrine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

propylhexedrine: was heading 1976-94 (see under PROPYLAMINES 1976-90); use PROPYLAMINES to search PROPYLHEXEDRINE 1976-94; alpha-adrenergic stimulant used extensively in nasal decongestant inhalers [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID7558
CHEMBL ID2105275
CHEBI ID134783
SCHEMBL ID28537
SCHEMBL ID20780004
MeSH IDM0225274

Synonyms (94)

Synonym
methyl-(1-methyl-2-cyclohexylethyl)amine
101-40-6
propylhexedrin
1-cyclohexyl-2-(methylamino)propane
benzedrex
hydromethamphetamine
dristan
(cyclohexaneethyl)amine, n-.alpha.-dimethyl-
propylhexadrine
propylhexedrine
wln: l6tj a1y1&m1
obesin
nsc-32410
n-.alpha.-(dimethylcyclohexane)ethylamine
chp-depot
nsc32410
cyclohexaneethylamine, n-.alpha.-dimethyl-
cyclohexaneethanamine,.alpha.-dimethyl-
hexahydrodesoxyephedrine
1-cyclohexyl-n-methylpropan-2-amine
(cyclohexaneethyl)amine, n-alpha-dimethyl-
dristan inhaler
(+-)-n,alpha-dimethylcyclohexaneethylamine
brn 3194303
beta-cyclohexyl-isopropylmethylamin [german]
1-cyclohexyl-n-methyl-2-propanamine
cyclohexaneethylamine, alpha,n-dimethyl-
1-cyclohexyl-2-methylaminopropan [german]
cyclohexaneethanamine, n,alpha-dimethyl-, (+-)-
cyclohexaneethanamine, n,alpha-dimethyl-, (+-)
nsc 32410
einecs 202-939-3
n,alpha-dimethylcyclohexaneethylamine
cyclohexaneethanamine, n,.alpha.-dimethyl-
dristan inhaler (tn)
D05637
propylhexedrine (usp/inn)
CHEBI:134783
DB06714
STK664138
NCGC00182042-01
cas-101-40-6
dtxcid303526
(+/-) propylhexedrine
dtxsid1023526 ,
tox21_113077
CHEMBL2105275
propylhexedrine dl-form
dl-propylhexedrine
AKOS005172629
3595-11-7
FT-0674106
propylhexedrine [usp:inn:ban]
propilhexedrina
propilhexedrina [inn-spanish]
propilesedrina [dcit]
1-cyclohexyl-2-methylaminopropan
beta-cyclohexyl-isopropylmethylamin
propylhexedrinum
3-12-00-00108 (beilstein handbook reference)
propylhexedrinum [inn-latin]
einecs 222-741-0
propilesedrina
lqu92iu8ll ,
unii-lqu92iu8ll
propylhexedrine [inn]
propylhexedrine [who-dd]
propylhexedrine dl-form [mi]
propylhexedrine [vandf]
propylhexedrine [mart.]
(+/-)-n,.alpha.-dimethylcyclohexaneethanamine
propylhexedrine [usp monograph]
AB01331925-02
SCHEMBL28537
n,.alpha.-dimethylcyclohexaneethylamine
cyclohexaneethylamine, .alpha.,n-dimethyl-
cyclohexaneethanamine, n,.alpha.-dimethyl-, (.+/-.)
(.+/-.)-n,.alpha.-dimethylcyclohexaneethylamine
.alpha.,n-dimethylcyclohexaneethylamine
n-methyl-1-cyclohexylisopropylamine
cyclohexaneethanamine, n,alpha-dimethyl-
(1-cyclohexylpropan-2-yl)(methyl)amine
Q408704
SCHEMBL20780004
NCGC00182042-04
NCGC00182042-03
EN300-135610
propilhexedrina (inn-spanish)
propylhexedrinum (inn-latin)
propylhexedrine (usp monograph)
propylhexedrine (mart.)
(+/-)-n,alpha-dimethylcyclohexaneethanamine
propylhexedrine (usp:inn:ban)
benzedrex09-19-2014

Research Excerpts

Overview

Propylhexedrine is a potent alpha-adrenergic drug available as a nasal decongestant. Drug abusers sometimes extract and inject into a central vein.

ExcerptReferenceRelevance
"Propylhexedrine is a potent α-adrenergic sympathomimetic amine found in nasal decongestant inhalers."( A drug toxicity death involving propylhexedrine and mitragynine.
Holler, JM; Levine, B; Magluilo, J; McDonough-Bender, PC; Solomon, CJ; Vorce, SP, 2011)		1.37
"Propylhexedrine is a potent alpha-adrenergic drug available as a nasal decongestant, which drug abusers sometimes extract and inject into a central vein. "( Airway compromise and delayed death following attempted central vein injection of propylhexedrine.
Burton, BT; McGirr, JG; Perez, J, )		1.8

Toxicity

ExcerptReferenceRelevance
" Misuse of this drug can lead to serious and potentially fatal cardiac and psychiatric adverse effects."( Abuse or Misuse of OTC Decongestant Produces Serious Adverse Effects.
Aschenbrenner, DS, 2021)		0.62

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
secondary amino compoundA compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency56.23410.009610.525035.4813AID1479145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (50.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (20.00)24.3611
2020's3 (30.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 57.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index57.85 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index92.13 (26.88)
Search Engine Supply Index2.04 (0.95)

This Compound (57.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies3 (25.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (75.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetaminophen
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.. paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.		2.0610acetamides;
phenols		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
cyclooxygenase 3 inhibitor;
environmental contaminant;
ferroptosis inducer;
geroprotector;
hepatotoxic agent;
human blood serum metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
promethazine
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.. promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.		2.0610phenothiazines;
tertiary amine		anti-allergic agent;
anticoronaviral agent;
antiemetic;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
sedative
mitragynine
[no description available]		7.0610monoterpenoid indole alkaloid
morphine
Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.		2.0610morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
ConditionIndicatedRelationship StrengthStudiesTrials
Chemical Dependence
[description not available]		02.0610
Adverse Drug Event
[description not available]		02.0610
Substance-Related Disorders
Disorders related to substance use or abuse.		02.0610
Drug-Related Side Effects and Adverse Reactions
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.		02.0610
Nasal Catarrh
[description not available]		01.9310
Rhinitis
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.		01.9310
Poisoning
Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.		06.9410
A-V Dissociation
[description not available]		01.9210
Cardiovascular Diseases
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.		01.9210
Arteriosclerosis, Coronary
[description not available]		01.9310
Coronary Heart Disease
[description not available]		01.9310
Coronary Artery Disease
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.		01.9310
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.		01.9310