Page last updated: 2024-12-07
o-methylserine
Description
o-Methylserine is a non-proteinogenic amino acid that has been studied for its potential therapeutic properties. It has been shown to inhibit the activity of serine racemase, an enzyme involved in the synthesis of D-serine, a neurotransmitter implicated in learning and memory. o-Methylserine is also a potent inhibitor of the enzyme serine hydroxymethyltransferase, which is involved in the biosynthesis of glycine. These findings suggest that o-Methylserine could be a potential therapeutic agent for neurological disorders. There are various synthetic methods for o-Methylserine. One method involves the alkylation of serine with methyl iodide in the presence of a base. Another method involves the condensation of formaldehyde with glycine in the presence of a catalyst. o-Methylserine has been shown to be effective in treating a variety of neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. o-Methylserine is a promising drug candidate for the treatment of neurological disorders, and further research is ongoing to explore its therapeutic potential.'
O-methylserine: RN given refers to compound with no isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
O-methylserine : A serine derivative that is L-serine with a methyl group replacing the hydrogen on the hydroxy side chain. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 88250 |
| CHEMBL ID | 4085261 |
| CHEBI ID | 74798 |
| SCHEMBL ID | 127190 |
| MeSH ID | M0252523 |
Synonyms (34)
| Synonym |
|---|
| AC-1107 |
| o-methylserine |
| 4219-94-7 |
| nsc-62335 |
| 32620-11-4 |
| 3-methoxyalanine |
| serine, o-methyl- |
| o-methyl-l-serine |
| (2s)-2-amino-3-methoxypropanoic acid |
| (s)-2-amino-3-methoxypropanoic acid |
| dl-serine, o-methyl- |
| r5mjk98ykk , |
| o-methyl-l-ser |
| CHEBI:74798 |
| nsc 62335 |
| BP-11131 |
| SCHEMBL127190 |
| AM808146 |
| (2s)-2-amino-3-methoxy-propanoic acid |
| l-serine, o-methyl- |
| alanine, 3-methoxy-, dl- |
| J-507795 |
| CS-W006151 |
| (s)-2-amino-3-methoxy-propionic acid (h-l-ser(me)-oh) |
| mfcd00145257 |
| DS-5174 |
| Q27144909 |
| DTXSID60941607 |
| h-ser(me)-oh |
| o-methyl-serine |
| CHEMBL4085261 |
| AKOS016843672 |
| F10843 |
| EN300-191527 |
Roles (1)
| Role | Description |
|---|
| metabolite | Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (2)
| Class | Description |
|---|
| L-serine derivative | A proteinogenic amino acid derivative resulting from reaction of L-serine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-serine by a heteroatom. |
| non-proteinogenic L-alpha-amino acid | Any L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.58
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.58 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.37 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |