o-methylserine profile

o-Methylserine is a non-proteinogenic amino acid that has been studied for its potential therapeutic properties. It has been shown to inhibit the activity of serine racemase, an enzyme involved in the synthesis of D-serine, a neurotransmitter implicated in learning and memory. o-Methylserine is also a potent inhibitor of the enzyme serine hydroxymethyltransferase, which is involved in the biosynthesis of glycine. These findings suggest that o-Methylserine could be a potential therapeutic agent for neurological disorders. There are various synthetic methods for o-Methylserine. One method involves the alkylation of serine with methyl iodide in the presence of a base. Another method involves the condensation of formaldehyde with glycine in the presence of a catalyst. o-Methylserine has been shown to be effective in treating a variety of neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. o-Methylserine is a promising drug candidate for the treatment of neurological disorders, and further research is ongoing to explore its therapeutic potential.'

O-methylserine: RN given refers to compound with no isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

O-methylserine : A serine derivative that is L-serine with a methyl group replacing the hydrogen on the hydroxy side chain. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	88250
CHEMBL ID	4085261
CHEBI ID	74798
SCHEMBL ID	127190
MeSH ID	M0252523

Synonym
AC-1107
o-methylserine
4219-94-7
nsc-62335
32620-11-4
3-methoxyalanine
serine, o-methyl-
o-methyl-l-serine
(2s)-2-amino-3-methoxypropanoic acid
(s)-2-amino-3-methoxypropanoic acid
dl-serine, o-methyl-
r5mjk98ykk ,
o-methyl-l-ser
CHEBI:74798
nsc 62335
BP-11131
SCHEMBL127190
AM808146
(2s)-2-amino-3-methoxy-propanoic acid
l-serine, o-methyl-
alanine, 3-methoxy-, dl-
J-507795
CS-W006151
(s)-2-amino-3-methoxy-propionic acid (h-l-ser(me)-oh)
mfcd00145257
DS-5174
Q27144909
DTXSID60941607
h-ser(me)-oh
o-methyl-serine
CHEMBL4085261
AKOS016843672
F10843
EN300-191527

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
L-serine derivative	A proteinogenic amino acid derivative resulting from reaction of L-serine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-serine by a heteroatom.
non-proteinogenic L-alpha-amino acid	Any L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (40.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
2-aminoadipic acid 2-Aminoadipic Acid: A metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).. 2-aminoadipic acid : An alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.	1.99	1	amino dicarboxylic acid; dicarboxylic fatty acid; non-proteinogenic alpha-amino acid	Caenorhabditis elegans metabolite; mammalian metabolite
pyridoxal phosphate Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).. pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.	2.43	2	methylpyridines; monohydroxypyridine; pyridinecarbaldehyde; vitamin B6 phosphate	coenzyme; cofactor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
serine Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.	3.11	5	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
valine Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.	1.99	1	L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid; valine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
glycyl-glycyl-glycine glycyl-glycyl-glycine : A tripeptide in which three glycine units are linked via peptide bonds in a linear sequence.	2.07	1	tripeptide zwitterion; tripeptide
glycylglycine [no description available]	2.07	1	dipeptide zwitterion; dipeptide	human metabolite
manganese Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.	2.07	1	elemental manganese; manganese group element atom	Escherichia coli metabolite; micronutrient
molybdenum Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.	2.07	1	chromium group element atom	micronutrient
rhenium Rhenium: A metal, atomic number 75, atomic weight 186.207, symbol Re.	2.07	1	manganese group element atom
glycylvaline glycylvaline: RN given refers to (DL)-isomer	2.07	1	dipeptide	human metabolite

Condition	Indicated	Relationship Strength	Studies	Trials
Cancer of Lung [description not available]	0	2.04	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	0	2.04	1	0

o-methylserine

Description

Cross-References

Synonyms (34)

Roles (1)

Drug Classes (2)

Research

Studies (5)

Market Indicators

Research Demand Index: 12.58

Study Types