Compounds > lysyl-tryptophyl-alpha-lysine
Page last updated: 2024-11-08

lysyl-tryptophyl-alpha-lysine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

lysyl-tryptophyl-alpha-lysine: RN & N1 from 9th CI Form Index; RN given refers to (all-L)-isomer; KWK-CO2 is the positively charged oligopeptide [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID161970
CHEBI ID160356
SCHEMBL ID3384748
MeSH IDM0094184

Synonyms (26)

Synonym
1JEV ,
lysyl-tryptophyl-alpha-lysine
n2-(n-l-lysyl-l-tryptophyl)-l-lysine
ccris 2594
l-lysine, n(2)-(n-l-lysyl-l-tryptophyl)-
CHEBI:160356
(2s)-6-amino-2-[[(2s)-2-[[(2s)-2,6-diaminohexanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]hexanoic acid
38579-27-0
lys-trp-lys
SCHEMBL3384748
lysyl-tryptophyl-lysine carboxylate
kwk-co2
lysyltryptophyllysine
lys-trp-lys acetate
AKOS030531735
h-lys-trp-lys-oh
CS-8122
l-lysyl-l-tryptophanyl-l-lysine
lysyl-tryptophanyl-lysine
HY-P1350
A16959
(s)-6-amino-2-((s)-2-((s)-2,6-diaminohexanamido)-3-(1h-indol-3-yl)propanamido)hexanoic acid
MS-28457
n~2~-{2-[(2,6-diamino-1-hydroxyhexylidene)amino]-1-hydroxy-3-(1h-indol-3-yl)propylidene}lysine
DTXSID00959443
(2s)-6-amino-2-[(2s)-2-[(2s)-2,6-diaminohexanamido]-3-(1h-indol-3-yl)propanamido]hexanoic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
oligopeptideA peptide containing a relatively small number of amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Oligo-peptide Binding ProteinSalmonella enterica subsp. enterica serovar TyphimuriumKd0.13000.13000.13000.1300AID977611
Chain A, Oligo-peptide Binding ProteinSalmonella enterica subsp. enterica serovar TyphimuriumKd0.13000.13000.13000.1300AID977611
Chain A, Oligo-peptide Binding ProteinSalmonella enterica subsp. enterica serovar TyphimuriumKd0.13000.13000.13000.1300AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB1996Nature structural biology, Dec, Volume: 3, Issue:12
The role of water in sequence-independent ligand binding by an oligopeptide transporter protein.
AID1811Experimentally measured binding affinity data derived from PDB1996Nature structural biology, Dec, Volume: 3, Issue:12
The role of water in sequence-independent ligand binding by an oligopeptide transporter protein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (31.82)18.7374
1990's5 (22.73)18.2507
2000's6 (27.27)29.6817
2010's4 (18.18)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.11

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.11 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index4.29 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.11)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.35%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (95.65%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methane
Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).		2.1310alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		1.9710elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
mercaptoethanol
Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.		1.9610alkanethiol;
primary alcohol		geroprotector
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		2.1310aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		3.1150erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
sodium hydroxide
Sodium Hydroxide: A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)		1.9710alkali metal hydroxide
mercury
Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.		1.9610elemental mercury;
zinc group element atom		neurotoxin
dimyristoylphosphatidylserine
[no description available]		2.0110
lysyl-tyrosyl-lysine
[no description available]		210oligopeptide
angiotensin ii
Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).		1.9810amino acid zwitterion;
angiotensin II		human metabolite
bradykinin
[no description available]		1.9810oligopeptidehuman blood serum metabolite;
vasodilator agent
lysylglycine
lysylglycine: structure in first source. Lys-Gly : A dipeptide formed from L-lysine and glycine residues.		2.1310dipeptidemetabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		0210