Compounds > lysyl-tyrosyl-lysine

Page last updated: 2024-12-05

lysyl-tyrosyl-lysine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID Source	ID
PubMed CID	147602
CHEMBL ID	3138622
CHEBI ID	160394
SCHEMBL ID	6275116
MeSH ID	M0200688

Synonyms (14)

Synonym
1B58
(2s)-6-amino-2-[[(2s)-2-[[(2s)-2,6-diaminohexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoic acid
CHEBI:160394
lys-tyr-lys
35193-18-1
l-lysine, n2-(n-l-lysyl-l-tyrosyl)-
lysyl-tyrosyl-lysine
CHEMBL3138622
SCHEMBL6275116
l-lysyl-l-tyrosyl-l-lysine
(s)-6-amino-2-((s)-2-((s)-2,6-diaminohexanamido)-3-(4-hydroxyphenyl)propanamido)hexanoic acid
n~2~-{2-[(2,6-diamino-1-hydroxyhexylidene)amino]-1-hydroxy-3-(4-hydroxyphenyl)propylidene}lysine
DTXSID90956643
AKOS040744754

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
oligopeptide	A peptide containing a relatively small number of amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (16)

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN)	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, Periplasmic Oligopeptide-binding Protein	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
Chain A, Periplasmic Oligopeptide-binding Protein	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	0.2600	0.2600	0.2600	0.2600	AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	1999	Journal of molecular biology, Aug-13, Volume: 291, Issue:2	Crystallographic and calorimetric analysis of peptide binding to OppA protein.
AID1811	Experimentally measured binding affinity data derived from PDB	1999	Journal of molecular biology, Aug-13, Volume: 291, Issue:2	Crystallographic and calorimetric analysis of peptide binding to OppA protein.
AID977602	Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	2013	Molecular pharmacology, Jun, Volume: 83, Issue:6	Structure-based identification of OATP1B1/3 inhibitors.
AID977599	Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	2013	Molecular pharmacology, Jun, Volume: 83, Issue:6	Structure-based identification of OATP1B1/3 inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (37.50)	18.2507
2000's	3 (37.50)	29.6817
2010's	1 (12.50)	24.3611
2020's	1 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
uracil 2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder	6.99	1	0	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	2	1	0	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
bromodeoxyuridine Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.	6.99	1	0	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	2	1	0	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
18-crown-6 18-crown-6 : A crown ether that is cyclooctadecane in which the carbon atoms at positions 1, 4, 7, 10, 13 and 16 have been replaced by oxygen atoms.	2.31	1	0	crown ether; saturated organic heteromonocyclic parent	phase-transfer catalyst
lysyl-tryptophyl-alpha-lysine lysyl-tryptophyl-alpha-lysine: RN & N1 from 9th CI Form Index; RN given refers to (all-L)-isomer; KWK-CO2 is the positively charged oligopeptide	2	1	0	oligopeptide
deoxyguanosine [no description available]	1.98	1	0	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
deoxycytidylyl-(3'-5')-deoxyguanosine deoxycytidylyl-(3'-5')-deoxyguanosine: RN given refers to parent cpd. dCpdG : A (3'->5')-dinucleotide consisting of 2'-deoxyguanosine having a 2'-deoxycytidylyl-3-phospho moiety attached at the 5-position.	1.98	1	0	(3'->5')-dinucleotide