Compounds > kalkitoxin

Page last updated: 2024-11-12

kalkitoxin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

kalkitoxin: from marine cyanobacterium, Lyngbya majuscula [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	11176051
CHEBI ID	186963
MeSH ID	M0336720

Synonyms (13)

Synonym
(2r)-n-[(3s,5s,6r)-7-[(4r)-4-ethenyl-4,5-dihydro-1,3-thiazol-2-yl]-3,5,6-trimethylheptyl]-n,2-dimethylbutanamide
kalkitoxin
247184-89-0
CHEBI:186963
kalkitoxin, (+)-
kalkitoxin [mi]
butanamide, n-((3s,5s,6r)-7-((4r)-4-ethenyl-4,5-dihydro-2-thiazolyl)-3,5,6-trimethylheptyl)-n,2-dimethyl-, (2r)-
79jc6zx2r6 ,
unii-79jc6zx2r6
(2r)-n-((3s,5s,6r)-7-((4r)-4-ethenyl-4,5-dihydro-2-thiazolyl)-3,5,6-trimethylheptyl)-n,2-dimethylbutanamide
CCG-257470
Q27266756
DTXSID80897233

Research Excerpts

Overview

Kalkitoxin (KT) is an active lipopeptide isolated from the cyanobacterium.

Excerpt	Reference	Relevance
"Kalkitoxin (KT) is an active lipopeptide isolated from the cyanobacterium "	( Kalkitoxin attenuates calcification of vascular smooth muscle cells via RUNX-2 signaling pathways. Kim, SW; Shrestha, SK; Soh, Y, 2023)	3.8

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
fatty amide	A monocarboxylic acid amide derived from a fatty acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (10.00)	18.2507
2000's	3 (30.00)	29.6817
2010's	3 (30.00)	24.3611
2020's	3 (30.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.93

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	21.93 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	5.03 (4.65)
Search Engine Demand Index	18.60 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (21.93)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
alizarin [no description available]	2.6	1	0	dihydroxyanthraquinone	chromophore; dye; plant metabolite
thiazoles [no description available]	3.55	8	0	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
decamethrin decamethrin: pyrethroid insecticide; RN given refers to cpd without isomeric designation; structure	2.02	1	0	aromatic ether; cyclopropanecarboxylate ester; nitrile; organobromine compound	agrochemical; antifeedant; calcium channel agonist; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; pyrethroid ester insecticide
curacin a curacin A: RN refers to curacin A (the Z,E,E-isomer), the major lipid component of a strain of the marine cyanobacterium Lyngbya majuscula; structure given in first source	2	1	0	thiazoles
dextrorphan Dextrorphan: Dextro form of levorphanol. It acts as a noncompetitive NMDA receptor antagonist, among other effects, and has been proposed as a neuroprotective agent. It is also a metabolite of DEXTROMETHORPHAN.	2	1	0	morphinane alkaloid
dizocilpine maleate Dizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.. dizocilpine maleate : A maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid.	2	1	0	maleate salt; tetracyclic antidepressant	anaesthetic; anticonvulsant; neuroprotective agent; nicotinic antagonist; NMDA receptor antagonist
antillatoxin antillatoxin: a neurotoxic lipopeptide from marine cyanobacterium, Lyngbya majuscula	7	1	0
veratridine Veratridine: A benzoate-cevane found in VERATRUM and Schoenocaulon. It activates SODIUM CHANNELS to stay open longer than normal.	2.02	1	0
phthioceranic acid phthioceranic acid: a heptamethyl-branched acid from Mycobacterium tuberculosis; structure in first source	7.11	1	0
pyrethrins [no description available]	2.02	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Metastase [description not available]	0	2.6	1	0
Osteolysis Dissolution of bone that particularly involves the removal or loss of calcium.	0	2.6	1	0
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	0	2.6	1	0
Vascular Calcification Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.	0	2.6	1	0
Rodent Diseases Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).	0	2.6	1	0
Bone Loss, Osteoclastic [description not available]	0	2.31	1	0
Innate Inflammatory Response [description not available]	0	2.31	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.31	1	0
Breast Cancer [description not available]	0	2.11	1	0
Angiogenesis, Pathologic [description not available]	0	2.11	1	0
Breast Neoplasms Tumors or cancer of the human BREAST.	0	2.11	1	0