kalkitoxin has been researched along with antillatoxin* in 1 studies
1 other study(ies) available for kalkitoxin and antillatoxin
Article | Year |
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Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity.
Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1+/-6.4 and 3.86+/-1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cerebellum; Cyanobacteria; Cyclopropanes; Dextrorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Lethal Dose 50; Lipids; Lipopeptides; Lipoproteins; Marine Toxins; Neurons; Neuroprotective Agents; Neurotoxins; Peptides, Cyclic; Rats; Receptors, N-Methyl-D-Aspartate; Thiazoles | 1999 |