kalkitoxin and antillatoxin

kalkitoxin has been researched along with antillatoxin* in 1 studies

Other Studies

1 other study(ies) available for kalkitoxin and antillatoxin

Article	Year
Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity. Toxicon : official journal of the International Society on Toxinology, 1999, Volume: 37, Issue:11 Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1+/-6.4 and 3.86+/-1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cerebellum; Cyanobacteria; Cyclopropanes; Dextrorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Lethal Dose 50; Lipids; Lipopeptides; Lipoproteins; Marine Toxins; Neurons; Neuroprotective Agents; Neurotoxins; Peptides, Cyclic; Rats; Receptors, N-Methyl-D-Aspartate; Thiazoles	1999

Article

Year

Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity.

Toxicon : official journal of the International Society on Toxinology, 1999, Volume: 37, Issue:11

Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1+/-6.4 and 3.86+/-1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801.

Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cerebellum; Cyanobacteria; Cyclopropanes; Dextrorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Lethal Dose 50; Lipids; Lipopeptides; Lipoproteins; Marine Toxins; Neurons; Neuroprotective Agents; Neurotoxins; Peptides, Cyclic; Rats; Receptors, N-Methyl-D-Aspartate; Thiazoles

1999