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ChEBI ID: 62914
| Member | Definition | Class |
|---|---|---|
| iwr-1 endo | A dicarboximide having an endo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group. | IWR-1-endo |
| iwr-1 exo | A dicarboximide having an exo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group. It is a weak axin stabilizer, an analogue of IWR-1-endo. | IWR-1-exo |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 5 (33.33) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (5.26%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 18 (94.74%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase 1 | Homo sapiens (human) | IC50 | 55.6125 | 4 | 4 |
| Poly [ADP-ribose] polymerase 2 | Homo sapiens (human) | IC50 | 53.4900 | 5 | 5 |
| Poly [ADP-ribose] polymerase tankyrase-1 | Homo sapiens (human) | IC50 | 17.2645 | 7 | 8 |
| Poly [ADP-ribose] polymerase tankyrase-1 | Mus musculus (house mouse) | IC50 | 0.1310 | 1 | 1 |
| Poly [ADP-ribose] polymerase tankyrase-2 | Homo sapiens (human) | IC50 | 15.1931 | 8 | 9 |
| Poly [ADP-ribose] polymerase tankyrase-2 | Mus musculus (house mouse) | IC50 | 0.0560 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase tankyrase-1 | Homo sapiens (human) | EC50 | 2.5000 | 1 | 1 |
| Poly [ADP-ribose] polymerase tankyrase-2 | Homo sapiens (human) | EC50 | 2.5667 | 2 | 3 |
| Proto-oncogene Wnt-3 | Homo sapiens (human) | EC50 | 5.0000 | 1 | 1 |