iwr-1-exo has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for iwr-1-exo and Neoplasms
Article | Year |
---|---|
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
The pervasive influence of secreted Wnt signaling proteins in tissue homeostasis and tumorigenesis has galvanized efforts to identify small molecules that target Wnt-mediated cellular responses. By screening a diverse synthetic chemical library, we have discovered two new classes of small molecules that disrupt Wnt pathway responses; whereas one class inhibits the activity of Porcupine, a membrane-bound acyltransferase that is essential to the production of Wnt proteins, the other abrogates destruction of Axin proteins, which are suppressors of Wnt/beta-catenin pathway activity. With these small molecules, we establish a chemical genetic approach for studying Wnt pathway responses and stem cell function in adult tissue. We achieve transient, reversible suppression of Wnt/beta-catenin pathway response in vivo, and we establish a mechanism-based approach to target cancerous cell growth. The signal transduction mechanisms shown here to be chemically tractable additionally contribute to Wnt-independent signal transduction pathways and thus could be broadly exploited for chemical genetics and therapeutic goals. Topics: Axin Protein; beta Catenin; Humans; Molecular Structure; Neoplasms; Regeneration; Repressor Proteins; Signal Transduction; Wnt Proteins | 2009 |