Page last updated: 2024-11-13

halocidin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

halocidin: antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	45272204
CHEMBL ID	562966
MeSH ID	M0432832

Synonyms (2)

Synonym
CHEMBL562966
halocidin

Research Excerpts

Overview

Halocidin is a heterodimeric antimicrobial peptide. It is isolated from hemocytes from the tunicate, Halocynthiaaurantium.

Excerpt	Reference	Relevance
"Halocidin is an antimicrobial peptide found in the tunicate. "	( Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection. Jang, WS; Kim, BS; Lee, IH; Lee, SC; Lee, SH; Lee, YS; Shin, KH; Shin, YP; Sung, BH, 2007)	2.09
"Halocidin is a heterodimer antimicrobial peptide previously isolated from the tunicate Halocynthia aurantium. "	( Biological activities of synthetic analogs of halocidin, an antimicrobial peptide from the tunicate Halocynthia aurantium. Jang, WS; Kim, CH; Kim, KN; Lee, IH; Lee, JH; Park, SY; Son, SM, 2003)	2.02
"Halocidin is a heterodimeric antimicrobial peptide isolated from a tunicate, Halocynthia aurantium. "	( Monomeric analogues of halocidin. Doisy, X; Hansen, PR; Ifrah, D, 2004)	2.08
"Halocidin is an antimicrobial peptide, which is isolated from hemocytes from the tunicate, Halocynthiaaurantium. "	( cDNA cloning of halocidin and a new antimicrobial peptide derived from the N-terminus of Ci-META4. Chae, HJ; Jang, WS; Kang, MS; Kim, CH; Lee, IH; Seo, SJ; Son, SM, 2005)	2.12
"Halocidin is an antimicrobial peptide isolated from the hemocytes of the tunicate. "	( Antifungal activity of synthetic peptide derived from halocidin, antimicrobial peptide from the tunicate, Halocynthia aurantium. Han, YS; Jang, WS; Kim, HK; Kim, SA; Lee, IH; Lee, KY, 2006)	2.02

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID425046	Antimicrobial activity against vancomycin-resistant Enterococcus faecium CCARM 5029 after 18 hrs by broth microdilution assay	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection.
AID425043	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3695 after 18 hrs by broth microdilution assay in presence of 150 mM NaCl	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection.
AID425050	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3695 treated with supernatant containing 2 mg drug incubated for 10 mins with PBS containing 50 % normal human serum centrifuged for 3 hrs by radial diffusion assay	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection.
AID425044	Antimicrobial activity against Listeria monocytogenes ATCC 19111 after 18 hrs by broth microdilution assay	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection.
AID425051	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3695 treated with supernatant containing 2 mg drug incubated for 10 mins with PBS centrifuged for 3 hrs by radial diffusion assay	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection.
AID425045	Antimicrobial activity against Listeria monocytogenes ATCC 19111 after 18 hrs by broth microdilution assay in presence of 150 mM NaCl	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection.
AID425047	Antimicrobial activity against vancomycin-resistant Enterococcus faecium CCARM 5029 after 18 hrs by broth microdilution assay in presence of 150 mM NaCl	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection.
AID425042	Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3695 after 18 hrs by broth microdilution assay	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (57.14)	29.6817
2010's	6 (42.86)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.68

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.68 (24.57)
Research Supply Index	2.71 (2.92)
Research Growth Index	4.39 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.68)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	2.02	1	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
leucine Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.	2.02	1	amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
sodium azide Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).	2.13	1	inorganic sodium salt	antibacterial agent; explosive; mitochondrial respiratory-chain inhibitor; mutagen
dimyristoylphosphatidylserine [no description available]	2.07	1
epiglucan epiglucan: a highly side-chain/branched alkali-insoluble cell wall glucan from fungus such as Epicoccum nigrum, Botrytis cinerea, ascomycetes & basidiomycetes; also isolated S-4001 from Lei Wan (polyporus mylitiae), HA-beta-glucan from mushroom Pleutotus ostreatus (Fr.) Quel., and translam from seaweed Laminaria cichorioides; with commercially important functional properties including emulsification and friction reduction.	2.03	1
alpha-chymotrypsin Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.	2.05	1
dimyristoylphosphatidylcholine 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).. dimyristoyl phosphatidylcholine : A phosphatidylcholine where the phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).	2.07	1	1,2-diacyl-sn-glycero-3-phosphocholine; phosphatidylcholine 28:0; tetradecanoate ester	antigen; mouse metabolite
melitten Melitten: Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.	2.01	1
forapin Forapin: used as ointment for treatment of myositis & arthritis; contains bee venom, salicylate, nicotinate & vanillylnonamide	2.03	1	peptidyl amide; polypeptide	animal metabolite; antineoplastic agent; apoptosis inducer; EC 2.7.11.13 (protein kinase C) inhibitor; hepatoprotective agent; neuroprotective agent; venom

Condition	Relationship Strength	Studies
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.46	2
Extravascular Hemolysis [description not available]	2.71	3
Infections, Listeria [description not available]	2.03	1
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	2.71	3
Infections, Staphylococcal [description not available]	2.06	1
Infection, Postoperative Wound [description not available]	2.06	1
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.06	1
Moniliasis, Oral [description not available]	2.08	1
Candidiasis, Oral Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)	2.08	1

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