guanacastepene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

guanacastepene: isolated from an unidentified fungus; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10384802
SCHEMBL ID	2034896
MeSH ID	M0364044

Synonyms (14)

Synonym
guanacastepene a
263357-41-1
SCHEMBL2034896
DTXSID10439100
[(2r,3r,3ar,5ar,8s)-9-formyl-8-hydroxy-3a,5a-dimethyl-1-oxo-3-propan-2-yl-3,4,5,6,7,8-hexahydro-2h-benzo[f]azulen-2-yl] acetate
Q15411011
guanacastepene
(1r,2r,6s,8ar,10ar)-2-(acetyloxy)-1,2,3,6,7,8,8a,9,10,10a-decahydro-6-hydroxy-8a,10a-dimethyl-1-(1-methylethyl)-3-oxobenz[f]azulene-5-carboxaldehyde
463962-78-9
(1r,2r,6s,8ar,10ar)-2-(acetyloxy)-1,2,3,6,7,8,8a,9,10,10a-decahydro-6-hydroxy-8a,10a-dimethyl-1-(1-methylethyl)-3-oxobenz(f)azulene-5-carboxaldehyde
unii-g5h7zb2hdf
g5h7zb2hdf ,
guanacastepene a, (+)-
(+)-guanacastepene

Research Excerpts

Overview

The guanacastepenes are a family of 15 diterpenes that share a common 5-6-7 tricyclic core, which is decorated with quaternary centers.

Excerpt	Reference	Relevance
"The guanacastepenes are a family of 15 diterpenes that share a common 5-6-7 tricyclic core, which is decorated with quaternary centers, unsaturation, hydroxyl and carbonyl groups. "	( Cyclohexyne cycloinsertion in the divergent synthesis of guanacastepenes. Carreira, EM; Gampe, CM, 2012)	1.18

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (35)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	29 (82.86)	29.6817
2010's	6 (17.14)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.66 (24.57)
Research Supply Index	3.58 (2.92)
Research Growth Index	6.25 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (5.71%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	33 (94.29%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	2.03	1	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
1,3-butadiene buta-1,3-diene : A butadiene with unsaturation at positions 1 and 3.	7.03	1	butadiene	carcinogenic agent; mutagen
cyclohexanone [no description available]	2.01	1	cyclohexanones	human xenobiotic metabolite
furan furan : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.	2.01	1	furans; mancude organic heteromonocyclic parent; monocyclic heteroarene	carcinogenic agent; hepatotoxic agent; Maillard reaction product
azulene [no description available]	7	1	azulenes; mancude carbobicyclic parent; ortho-fused bicyclic arene	plant metabolite; volatile oil component
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	2.41	2	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
1,4-cyclohexadiene [no description available]	2.01	1	cyclohexadiene
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2	1	metal allergen; nickel group element atom; platinum group metal atom
rhodium Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.	2.02	1	cobalt group element atom
ruthenium Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.	2.01	1	iron group element atom; platinum group metal atom
bromine Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.	2.01	1	diatomic bromine
tiletamine hydrochloride Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.	2.01	1
alkenes [no description available]	2	1
cyclobutanol cyclobutanol: structure in first source	2.07	1
cyclopropene cyclopropene: structure. cyclopropene : A cycloalkene that consists of cyclopropane having a double bond in the ring. The parent of the class of cyclopropenes.	2.03	1	cycloalkene; cyclopropenes
ingenol [no description available]	3.13	1	cyclic terpene ketone; tetracyclic diterpenoid
sesquiterpenes [no description available]	2.03	1
resiniferatoxin resiniferatoxin: phorbol related diterpene ester; potent agonist of vanilloid TRPV1 receptors. resiniferatoxin : A heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1).	3.13	1	carboxylic ester; diterpenoid; enone; monomethoxybenzene; organic heteropentacyclic compound; ortho ester; phenols; tertiary alpha-hydroxy ketone	analgesic; neurotoxin; plant metabolite; TRPV1 agonist
terpestacin terpestacin: structure given in first source; isolated from Arthrinium; inhibits syncytium (giant cell) formation	3.13	1	secondary alcohol
phomactin a phomactin A: RN given for (3S-(3R,4S,6R,9E,13R,14S,16R))-isomer; isolated from Phoma; structure in first source	3.13	1
eleutherobin eleutherobin: structure in first source	3.13	1
saudin saudin: structure in first source	3.13	1
bryostatin 1 bryostatin 1: a protein kinase C activator; macrocyclic lactone from marine Bryozoan Bugula neritina; RN given refers to (1S-(1R,3R,5Z,7S,8E,11R,12R(2E,4E),13E,15R,17S(S),21S,23S,25R))-isomer; structure given in first source; activates protein kinase c. bryostatin 1 : A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.	2.03	1

Condition	Indicated	Relationship Strength	Studies	Trials
Extravascular Hemolysis [description not available]	0	2	1	0
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	0	2	1	0

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