Compounds > aguerin b
Page last updated: 2024-12-08

aguerin b

Description

aguerin B: has antiproliferative activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID155102
CHEMBL ID520721
MeSH IDM000606179

Synonyms (9)

Synonym
[(3ar,4s,6ar,8s,9ar,9br)-8-hydroxy-3,6,9-trimethylidene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] 2-methylprop-2-enoate
CHEMBL520721
aguerin b
arguerin b
4'-deoxycynaropicrin
68370-45-6
2-propenoic acid, 2-methyl-, (3ar,4s,6ar,8s,9ar,9br)-dodecahydro-8-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno(4,5-b)furan-4-yl ester
DTXSID20987920
8-hydroxy-3,6,9-trimethylidene-2-oxododecahydroazuleno[4,5-b]furan-4-yl 2-methylprop-2-enoate

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The results can be interpreted with respect to a reference model by considering dose-response analyses and isobolograms with linear regression analyses."( The Joint Action of Sesquiterpene Lactones from Leaves as an Explanation for the Activity of Cynara cardunculus.
García, BF; Macías, FA; Molinillo, JM; Rial, C; Torres, A; Varela, RM, 2016)		0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID606402Antiproliferative activity against human MIAPaCa2 cells after 48 hrs2011European journal of medicinal chemistry, Jul, Volume: 46, Issue:7
Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.
AID402670Cytotoxicity against human A549 cells after 3 days by SRB assay2005Journal of natural products, Jul, Volume: 68, Issue:7
Cytotoxic activity of some natural and synthetic guaianolides.
AID606481Antiproliferative activity against human COLO320 cells after 48 to 72 hrs2011European journal of medicinal chemistry, Jul, Volume: 46, Issue:7
Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.
AID606483Antiproliferative activity against human COLO320 cells2011European journal of medicinal chemistry, Jul, Volume: 46, Issue:7
Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.
AID1069397Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB 9002014Bioorganic & medicinal chemistry letters, Feb-01, Volume: 24, Issue:3
Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives.
AID606403Antiproliferative activity against human MIAPaCa2 cells after 72 hrs2011European journal of medicinal chemistry, Jul, Volume: 46, Issue:7
Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.
AID402671Cytotoxicity against human MCF7 cells after 3 days by SRB assay2005Journal of natural products, Jul, Volume: 68, Issue:7
Cytotoxic activity of some natural and synthetic guaianolides.
AID1069398Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay2014Bioorganic & medicinal chemistry letters, Feb-01, Volume: 24, Issue:3
Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives.
AID606474Antiproliferative activity against human COLO320 cells after 72 hrs2011European journal of medicinal chemistry, Jul, Volume: 46, Issue:7
Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.
AID606478Induction of apoptosis in human COLO320 cells assessed as increase of interneucleosomal DNA fragmentation at 5 uM after 24 hrs relative to control2011European journal of medicinal chemistry, Jul, Volume: 46, Issue:7
Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.
AID1069399Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB 900 after 70 hrs by alamar blue assay2014Bioorganic & medicinal chemistry letters, Feb-01, Volume: 24, Issue:3
Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives.
AID606473Antiproliferative activity against human COLO320 cells after 48 hrs2011European journal of medicinal chemistry, Jul, Volume: 46, Issue:7
Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.
AID606476Induction of apoptosis in human MIAPaCa2 cells assessed as increase of interneucleosomal DNA fragmentation at 5 uM after 24 hrs relative to control2011European journal of medicinal chemistry, Jul, Volume: 46, Issue:7
Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.
AID606482Antiproliferative activity against human MIAPaCa2 cells2011European journal of medicinal chemistry, Jul, Volume: 46, Issue:7
Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.
AID606475Antiproliferative activity against human HEK293 cells up to 100 uM2011European journal of medicinal chemistry, Jul, Volume: 46, Issue:7
Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.
AID606480Antiproliferative activity against human MIAPaCa2 cells after 48 to 72 hrs2011European journal of medicinal chemistry, Jul, Volume: 46, Issue:7
Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's4 (57.14)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.16 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index5.24 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.0610nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		2.0210mitomycinalkylating agent;
antineoplastic agent
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0210taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
cynaropicrin
cynaropicrin: structure given in first source; RN given for ((3aR-(3aalpha,4alpha,6aalpha,8beta,9aalpha,9bbeta)))-isomer		340sesquiterpene lactone
grosheimin
grosheimin: from the aerial parts of V. decurens; structure		2.1310sesquiterpene lactone
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.4110
sesquiterpenes
[no description available]		3.2650
hispidulin
hispidulin : A monomethoxyflavone that is scutellarein methylated at position 6.		2.1710monomethoxyflavone;
trihydroxyflavone		anti-inflammatory agent;
anticonvulsant;
antineoplastic agent;
antioxidant;
apoptosis inducer;
plant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.2510
Metastase
[description not available]		02.2510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.2510
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.2510
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