Compounds > f 6060
Page last updated: 2024-12-06

f 6060

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Description

F 6060: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID21260
CHEMBL ID6619
SCHEMBL ID3896286
MeSH IDM0045453

Synonyms (33)

Synonym
p-cresol, alpha-cyclohexylidene-alpha-(p-hydroxyphenyl)-
brn 2055864
alpha-cyclohexylidene-alpha-(p-hydroxyphenyl)-p-cresol
f 6060
einecs 225-972-5
4-(cyclohexylidene(4-hydroxyphenyl)methyl)phenol
4,4'-cyclohexylidenemethylenediphenol
phenol, 4-(cyclohexylidene(4-hydroxyphenyl)methyl)-
cyclofenil diphenol
4,4'-(cyclohexylidenemethylene)diphenol
5189-40-2
4-[cyclohexylidene(4-hydroxyphenyl)methyl]phenol
CHEMBL6619
4-cyclohexyliden(4-hydroxyphenyl)methylphenol
4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenol
4,4-cyclohexylidenemethylenediphenol
00w4083oml ,
bis(p-hydroxyphenyl)cyclohexylidenemethane
unii-00w4083oml
f-6060
f6060
FT-0646285
AKOS015900228
SCHEMBL3896286
phenol, 4,4'-(cyclohexylidenemethylene)bis-
p-cresol, .alpha.-cyclohexylidene-.alpha.-(p-hydroxyphenyl)-
.alpha.-cyclohexylidene-.alpha.-(p-hydroxyphenyl)-p-cresol
AC-26695
DTXSID80199845
bp_33
AMY11606
Q27231386
PD182147
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (40)

Assay IDTitleYearJournalArticle
AID473418Displacement of [3H]estradiol from full-length human estrogen receptor beta assessed as relative binding affinity by radiometric assay relative to estradiol2010Journal of medicinal chemistry, Apr-22, Volume: 53, Issue:8
Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs).
AID71132Relative binding affinity was measured on calf uterus estrogen receptor after 5 hr at 25C.1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID82018Transcriptional agonistic efficacy against ER beta at 10e-8 M by cotransfection in HEC-1 cells2003Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.
AID69704Relative binding affinity for sheep uterine estrogen receptor relative to estradiol as Ka(compound)/Ka(estradiol) x 1001980Journal of medicinal chemistry, Sep, Volume: 23, Issue:9
Estrogen receptor based imaging agents. 2. Synthesis and receptor binding affinity of side-chain halogenated hexestrol derivatives.
AID102623Percent of inhibitory activity against proliferation of MCF-7 cells in presence of 10e-6 M concentration of [3H]estradiol (E2).1989Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
AID103604Agonist activity against MCF-7 cell proliferation1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID103743Antagonist activity against MCF-7 cell proliferation; NM means not measurable1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID70483Binding affinity for purified human Estrogen receptor alpha was determined using a competitive radiometric binding assay with [3H]estradiol2003Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.
AID82017Transcriptional agonistic efficacy against ER alpha at 10e-8 M by cotransfection in HEC-1 cells2003Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.
AID102624Percent of inhibitory activity versus 0.1 nm [3H]estradiol against proliferation of MCF-7 cells.1989Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
AID231511Ratio of binding affinity for purified human estrogen alpha receptors to that of binding affinity for purified human estrogen beta receptors.2003Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.
AID71130Relative binding affinity for calf uterus estrogen receptor after 2 hr at 0 degree C1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID102449Inhibition of proliferation of MCF-7 cells in presence of 10e-6 M concentration of [3H]- estradiol (E2); nm = not measuable1989Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
AID234090Selectivity for relative binding affinity against estrogen receptor at 2 hrs and 5 hr in calf uterus cytosol1989Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
AID82019Transcriptional antagonistic efficacy agains ER alpha at 10e-6 M by cotransfection in HEC-1 cells2003Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.
AID67957Cytotoxic effect on ER-negative BT20 cell proliferation1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID71133Relative binding affinity against estrogen receptor in calf uterus cytosol using [3H]E2 as radioligand, incubated at 2 hours at 0 degree Centigrade.1989Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
AID164971Percent stimulation or inhibition of protein kinase C III activity for phosphatidylserine (PS) in the presence of [Ca2+].1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID102603Inhibition of proliferation of MCF-7 cells versus 0.1 nM [3H]- estradiol; nm = not measuable1989Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
AID103754Cytostatic activity against MCF-7 cell proliferation.1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID102768Percent of effective dose for [3H]estradiol against proliferation of MCF-7 cells.1989Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
AID262967Selectivity for ERalpha over ERbeta2006Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8
Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential positron emission tomography agents for imaging estrogen receptors in breast cancer.
AID103600Agonistic activity in MCF-7 cell proliferation.1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID473417Displacement of [3H]estradiol from full-length human estrogen receptor alpha assessed as relative binding affinity by radiometric assay relative to estradiol2010Journal of medicinal chemistry, Apr-22, Volume: 53, Issue:8
Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs).
AID42280Percent of inhibitory activity against proliferation of BT-20 cells in presence of TPE at 10e-5 M concentration.1989Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
AID42279Inhibition of proliferation of BT-20 cells in presence of 10e-5 TPE concentration; nm = not measuable1989Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
AID103601Antagonist activity against MCF-7 cell proliferation1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID262965Binding affinity to human ERalpha relative to estradiol by radiometric binding assay2006Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8
Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential positron emission tomography agents for imaging estrogen receptors in breast cancer.
AID103741Cytotoxic effect on MCF-7 cell proliferation; NM means not measurable1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID164972Percent stimulation or inhibition of protein kinase C III activity for protamine sulfate in the presence of EGTA.1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID71134Relative binding affinity against estrogen receptor in calf uterus cytosol using [3H]E2 as radioligand, incubated at 5 hours at 25 degree Centigrade.1989Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
AID262966Binding affinity to human ERbeta relative to estradiol by radiometric binding assay2006Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8
Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential positron emission tomography agents for imaging estrogen receptors in breast cancer.
AID164970The percent stimulation or inhibition of protein kinase C III activity was determined for phosphatidylserine (PS) and diolein(PS+DO) in the presence of [Ca2+]1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID102435Effective dose for [3H]- estradiol against proliferation of MCF-7 cells1989Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
AID82016Transcriptional agonistic efficacy against ER beta at 10e-6 M was determined by cotransfection in HEC-1 cells2003Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.
AID82020Transcriptional antagonistic efficacy against ERbeta at 10e-6 M by cotransfectio in HEC-1 cells2003Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.
AID67956Cytotoxic effect on ER-negative BT20 cell proliferation; Not measureable1992Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
AID70663Binding affinity for purified human Estrogen receptor beta was determined using a competitive radiometric binding assay with estradiol2003Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.
AID82015Transcriptional agonistic efficacy against ER alpha at 10e-6 M by cotransfection in HEC-1 cells2003Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9
Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.
AID473419Ratio of relative binding affinity for human ERbeta to relative binding affinity for human ERalpha2010Journal of medicinal chemistry, Apr-22, Volume: 53, Issue:8
Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (33.33)18.7374
1990's3 (33.33)18.2507
2000's2 (22.22)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.14

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index18.14 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (18.14)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cyclofenil
Cyclofenil: A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.		2.6730organic molecular entity
hexestrol
[no description available]		1.9510stilbenoid
2,3,3-triphenylacrylonitrile
2,3,3-triphenylacrylonitrile: structure given in first source		2.3820stilbenoid
1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene
1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene: structure given in first source		2.0510
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
[no description available]		2.3820stilbenoid
masoprocol
Masoprocol: A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.. masoprocol : The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.		1.9910nordihydroguaiaretic acidantineoplastic agent;
hypoglycemic agent;
lipoxygenase inhibitor;
metabolite
fulvestrant
Fulvestrant: An estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer.. fulvestrant : A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.		2.051017beta-hydroxy steroid;
3-hydroxy steroid;
organofluorine compound;
sulfoxide		antineoplastic agent;
estrogen antagonist;
estrogen receptor antagonist
1-fluorohexestrol
1-fluorohexestrol: estrogen-receptor-based agent for imaging of human breast tumors; RN given refers to (R*,S*)-isomer		1.9510
diethylstilbestrol
Diethylstilbestrol: A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed). diethylstilbestrol : An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.		1.9510olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
tamoxifen
[no description available]		2.3820stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
dimethylstilbestrol
dimethylstilbestrol: stilbene derivative with anti-estrogenic & anti-fertility activities; minor descriptor (75-85); on-line & Index Medicus search STILBENES (75-85); RN given refers to cpd without isomeric designation		1.9510stilbenoid
afimoxifene
[no description available]		2.3820
chondroitin sulfates
Chondroitin Sulfates: Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.		2.3720
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		03.0850
Breast Neoplasms
Tumors or cancer of the human BREAST.		03.0850
Chondrosarcoma
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)		02.3720