Page last updated: 2024-12-08
1-fluorohexestrol
Description
1-Fluorohexestrol is a synthetic nonsteroidal estrogen. It is a potent and selective estrogen receptor agonist, meaning it binds to and activates estrogen receptors in the body.
Here's why it's important for research:
* **Understanding Estrogen's Role:** 1-Fluorohexestrol acts as a tool to study the biological effects of estrogen and its receptors. Researchers can use it to investigate how estrogen influences various physiological processes, including:
* **Reproductive system:** Estrogen's role in menstrual cycle regulation, pregnancy, and fertility.
* **Bone health:** Estrogen's impact on bone density and osteoporosis.
* **Cardiovascular health:** Estrogen's influence on heart health and blood vessel function.
* **Brain function:** Estrogen's role in cognitive function, mood, and neuroprotection.
* **Developing New Therapeutics:** 1-Fluorohexestrol serves as a lead compound for the development of new drugs targeting estrogen receptors. It can help researchers:
* **Design new estrogen receptor modulators:** These drugs could potentially be used to treat various conditions like hormone-dependent cancers, menopausal symptoms, and osteoporosis.
* **Develop selective estrogen receptor agonists/antagonists:** This would allow for targeted therapeutic effects on specific tissues or organs, minimizing side effects.
* **Investigating Estrogen-Related Diseases:** 1-Fluorohexestrol can be used to model and study various estrogen-related diseases, such as:
* **Breast cancer:** Understanding how estrogen contributes to breast cancer development and progression.
* **Endometriosis:** Investigating the role of estrogen in the development and growth of endometrial tissue outside the uterus.
* **Polycystic ovary syndrome (PCOS):** Studying the impact of estrogen imbalances on PCOS.
**Important Considerations:**
* 1-Fluorohexestrol is a potent estrogen, so its use in research requires careful consideration and appropriate handling.
* The use of 1-Fluorohexestrol in humans is limited due to its potential side effects.
Overall, 1-Fluorohexestrol is a valuable research tool that helps scientists unravel the complex mechanisms of estrogen action and develop novel therapies for various conditions. However, its use requires careful consideration and appropriate ethical guidelines.
1-fluorohexestrol: estrogen-receptor-based agent for imaging of human breast tumors; RN given refers to (R*,S*)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 173293 |
| CHEMBL ID | 7192 |
| SCHEMBL ID | 8518129 |
| MeSH ID | M0083565 |
Synonyms (9)
| Synonym |
|---|
| 1-fluorohexestrol |
| CHEMBL7192 |
| 1-fluoro-3,4-bis(4-hydroxyphenyl)hexane |
| phenol, 4,4'-(1-ethyl-2-(2-fluoroethyl)-1,2-ethanediyl)bis-, (r*,s*)- |
| 74536-79-1 |
| erythro-1-fluoro-3,4-bis(4-hydroxyphenyl)hexane |
| SCHEMBL8518129 |
| 4,4'-(1-fluorohexane-3,4-diyl)diphenol |
| DTXSID60996056 |
Bioassays (2)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID69704 | Relative binding affinity for sheep uterine estrogen receptor relative to estradiol as Ka(compound)/Ka(estradiol) x 100 | 1980 | Journal of medicinal chemistry, Sep, Volume: 23, Issue:9
| Estrogen receptor based imaging agents. 2. Synthesis and receptor binding affinity of side-chain halogenated hexestrol derivatives. |
| AID70979 | The ratio of association constant for estrogen receptor using [3H]estradiol as a tracer, relative to estradiol | 1982 | Journal of medicinal chemistry, Nov, Volume: 25, Issue:11
| Nonsteroidal estrogens: synthesis and estrogen receptor binding affinity of derivatives of (3R*,4S*)-3,4-bis(4-hydroxyphenyl)hexane (hexestrol) and (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentane (norhexestrol) functionalized on the side chain. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.66
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.66 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.45 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |