Compounds > ervatamine
Page last updated: 2024-09-26

ervatamine

Description

ervatamine: do not confuse with the protein ervatamin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID161765
CHEBI ID141900
MeSH IDM0067961

Synonyms (8)

Synonym
epiervatamine
33257-13-5
CHEBI:141900
ervatamine
4-ethyl-2,3,4alpha,4aalpha,5,6,7,12-octahydro-2-methyl-6-oxopyrido(3',4':4,5)cyclohept(1,2-b)in dole-12aalpha(1h)-carboxylic acid methyl ester
DTXSID20954899
methyl 8-ethyl-10-methyl-6-oxo-6,7,7a,8,9,10,11,12-octahydropyrido[3',4':4,5]cyclohepta[1,2-b]indole-11a(5h)-carboxylate
methyl (3r,7s,8s)-7-ethyl-5-methyl-10-oxo-5,12-diazatetracyclo[9.7.0.03,8.013,18]octadeca-1(11),13,15,17-tetraene-3-carboxylate

Research Excerpts

Overview

ExcerptReference
"Ervatamine A (1) is a ring-C-contracted ibogan-type monoterpenoid indole alkaloid with an unusual 6/5/6/6/6 pentacyclic rearranged ring system."( Chen, JJ; Gao, K; Sun, M; Yao, XJ; Yu, DG; Zhang, DB; Zhou, SY; Zhu, XX, 2015)

Drug Classes (1)

ClassDescription
monoterpenoid indole alkaloidA terpenoid indole alkaloid which is biosynthesised from L-tryptophan and diisoprenoid (usually secolaganin) building blocks.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
tetrodotoxin[no description available]medium20azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
yohimbine[no description available]medium10methyl 17-hydroxy-20xi-yohimban-16-carboxylatealpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist
aminacrine[no description available]medium10aminoacridines;
primary amino compound		acid-base indicator;
antiinfective agent;
antiseptic drug;
fluorescent dye;
MALDI matrix material;
mutagen
saxitoxin[no description available]medium10alkaloid;
carbamate ester;
guanidines;
ketone hydrate;
paralytic shellfish toxin;
pyrrolopurine		cyanotoxin;
marine metabolite;
neurotoxin;
sodium channel blocker;
toxin
urethane[no description available]medium10carbamate esterfungal metabolite;
mutagen
alpha-aminopyridine[no description available]medium10
tabersonine[no description available]low00alkaloid ester;
methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound		antineoplastic agent;
metabolite
voacamine[no description available]low00alkaloid ester;
methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
plant metabolite
strychnine n-oxide[no description available]low00monoterpenoid indole alkaloid;
organic heteroheptacyclic compound;
tertiary amine oxide		plant metabolite
methyl reserpate[no description available]low00monoterpenoid indole alkaloid
strychnine[no description available]low00monoterpenoid indole alkaloid;
organic heteroheptacyclic compound		avicide;
cholinergic antagonist;
glycine receptor antagonist;
neurotransmitter agent;
rodenticide
raubasine[no description available]low00methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound		alpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent
brucine[no description available]low00monoterpenoid indole alkaloid;
organic heteroheptacyclic compound
mitragynine[no description available]low00monoterpenoid indole alkaloid
noribogaine[no description available]low00monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
secondary amino compound;
tertiary amino compound		kappa-opioid receptor agonist;
NMDA receptor antagonist;
psychotropic drug;
serotonin uptake inhibitor
pleiocarpamine[no description available]low00monoterpenoid indole alkaloid
catharanthine[no description available]low00alkaloid ester;
bridged compound;
methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound
coronardine[no description available]low00alkaloid ester;
methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound		antileishmanial agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite
vincosamide[no description available]low00monoterpenoid indole alkaloid
akuammicine[no description available]low00methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		plant metabolite
quinine[no description available]low00Aspidosperma alkaloid;
epoxide;
methyl ester;
monoterpenoid indole alkaloid;
organic heterohexacyclic compound		plant metabolite
leuconolam[no description available]low00monoterpenoid indole alkaloid
vindolinine[no description available]low00methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		plant metabolite
goniomitine[no description available]low00monoterpenoid indole alkaloid
stemmadenine[no description available]low00Aspidosperma alkaloid;
methyl ester;
monoterpenoid indole alkaloid;
organic heterotetracyclic compound;
primary alcohol		plant metabolite
lundurine a[no description available]low00monoterpenoid indole alkaloid
ConditionIndicatedRelationship StrengthStudiesTrials
Experimental Neoplasms0low10
Neoplasms, Experimental0low10
Neuroblastoma0low10