Circulin A is a cyclic peptide antibiotic produced by Bacillus circulans. It exhibits broad-spectrum antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Bacillus subtilis. Circulin A is known to inhibit bacterial cell wall synthesis, specifically by targeting the transpeptidases involved in peptidoglycan crosslinking. Its structure consists of a 16-membered ring containing ten amino acid residues, including a unique cyclic disulfide bridge. The synthesis of Circulin A involves a complex biosynthetic pathway, including non-ribosomal peptide synthesis and post-translational modification. Its potential therapeutic applications are under investigation, particularly for its antimicrobial properties and its ability to overcome resistance to conventional antibiotics. Research on Circulin A focuses on its structure-activity relationship, its mechanism of action, its potential for drug development, and its potential as a model for studying antibiotic resistance.'
circulin A: a macrocyclic knotted peptide having anti-HIV activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.88) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||