Page last updated: 2024-12-06

circulin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Circulin A is a cyclic peptide antibiotic produced by Bacillus circulans. It exhibits broad-spectrum antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Bacillus subtilis. Circulin A is known to inhibit bacterial cell wall synthesis, specifically by targeting the transpeptidases involved in peptidoglycan crosslinking. Its structure consists of a 16-membered ring containing ten amino acid residues, including a unique cyclic disulfide bridge. The synthesis of Circulin A involves a complex biosynthetic pathway, including non-ribosomal peptide synthesis and post-translational modification. Its potential therapeutic applications are under investigation, particularly for its antimicrobial properties and its ability to overcome resistance to conventional antibiotics. Research on Circulin A focuses on its structure-activity relationship, its mechanism of action, its potential for drug development, and its potential as a model for studying antibiotic resistance.'

circulin A: a macrocyclic knotted peptide having anti-HIV activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	65155
MeSH ID	M0268112

Synonyms (1)

Synonym
circulin a

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (16.67)	18.7374
1990's	3 (50.00)	18.2507
2000's	2 (33.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	17.88 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.64 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (17.88)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies
cystine [no description available]	2	1
circulin b [no description available]	2.65	3
kalata b1 kalata B1: a 29-residue cyclotide which has a cystine knot structure and beta-sheet; causes uterine contraction; the principal active component from Oldenlandia affinis; amino acid sequence given in first source	2.92	4

Condition	Relationship Strength	Studies
HIV Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.	6.99	1
Extravascular Hemolysis [description not available]	2	1
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	2	1

chemdatabank.com