Page last updated: 2024-12-07
7-acetyltaxol
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
7-acetyltaxol: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 124950 |
CHEMBL ID | 70999 |
MeSH ID | M0127220 |
Synonyms (7)
Synonym |
---|
7-acetyltaxol |
CHEMBL70999 |
92950-39-5 |
benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, (2ar-(2aalpha,4beta,4abeta,6beta,9a(alphar*,betas*),11alpha,12alpha,12aalpha,12balpha))- |
7-acetyl taxol |
7-acetyl paclitaxel |
[(1s,2s,3r,4s,7r,9s,10s,12r,15s)-4,9,12-triacetyloxy-15-[(2r,3s)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (8)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID230950 | Effect on microtubule assembly in MCF-7 cells, compared to paclitaxel (0.3 uM), given as ratio of respective ED50 | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22 | Synthesis and evaluation of paclitaxel C7 derivatives: solution phase synthesis of combinatorial libraries. |
AID338717 | In vivo cytotoxicity against mouse P388 cells at 26 mg/kg | |||
AID338718 | In vivo cytotoxicity against mouse P388 cells at 13 mg/kg | |||
AID232289 | Cytotoxicity activity was measured against resistant human breast cancer cell line MCF-7 with respect to ED50 of paclitaxel (2200-3700 nM) | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22 | Synthesis and evaluation of paclitaxel C7 derivatives: solution phase synthesis of combinatorial libraries. |
AID338720 | In vivo cytotoxicity against mouse P388 cells at 3.25 mg/kg | |||
AID232288 | Cytotoxicity activity was measured against human breast cancer cell line MCF-7 with respect to ED50 of paclitaxel (2 nM) | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22 | Synthesis and evaluation of paclitaxel C7 derivatives: solution phase synthesis of combinatorial libraries. |
AID338719 | In vivo cytotoxicity against mouse P388 cells at 6.5 mg/kg | |||
AID338712 | Cytotoxicity against human KB cells | |||
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (4)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 3 (75.00) | 18.7374 |
1990's | 1 (25.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.53
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.53) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |