| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively. | 2.4 | 2 | 0 | dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine | |
pyrimethamine
Maloprim: contains above 2 cpds | 2.02 | 1 | 0 | aminopyrimidine;
monochlorobenzenes | antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor |
sulfadiazine
Sulfadiazine: One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.. sulfadiazine : A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.. diazine : The parent structure of the diazines. | 2.02 | 1 | 0 | pyrimidines;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antiinfective agent;
antimicrobial agent;
antiprotozoal drug;
coccidiostat;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
xenobiotic |
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. | 3.14 | 1 | 0 | mitomycin | alkylating agent;
antineoplastic agent |
triparanol
Triparanol: Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts. | 1.97 | 1 | 0 | stilbenoid | anticoronaviral agent |
aziridine
[no description available] | 3.14 | 1 | 0 | azacycloalkane;
aziridines;
saturated organic heteromonocyclic parent | alkylating agent |
porfiromycin
Porfiromycin: Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties. | 3.14 | 1 | 0 | | |
mitomycin a
mitomycin A: RN given refers to (1aS-(1aalpha,8beta,8aalpha,8balpha))-isomer; structure given in first source. mitomycin A : A member of the family of mitomycins that exhibits antibiotic and antitumour properties as well as a high level of toxicity. | 3.14 | 1 | 0 | ether;
mitomycin | alkylating agent;
antimicrobial agent;
antineoplastic agent;
toxin |
cycloartenol
[no description available] | 2.15 | 1 | 0 | 3beta-sterol;
pentacyclic triterpenoid;
phytosterols | plant metabolite |
imiphos
imiphos: structure | 3.14 | 1 | 0 | | |
n-methylmitomycin a
[no description available] | 3.14 | 1 | 0 | | |
azicemicin a
azicemicin A: structure given in first source; isolated from Amycolatopsis | 3.14 | 1 | 0 | | |
lanosterol
[no description available] | 3.71 | 10 | 0 | 14alpha-methyl steroid;
3beta-sterol;
tetracyclic triterpenoid | bacterial metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite |
ergosterol
[no description available] | 1.97 | 1 | 0 | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols | fungal metabolite;
Saccharomyces cerevisiae metabolite |
pregnanediol
[no description available] | 2.05 | 1 | 0 | | |
cholestanol
Cholestanol: A cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. | 3.11 | 5 | 0 | cholestanoid | |
antazirine
antazirine: RN refers to (4Z)-isomer; isolated from Dysidea fragilis; structure in first source | 3.14 | 1 | 0 | alpha-amino acid ester | |
phytosterols
Phytosterols: A class of organic compounds known as sterols or STEROIDS derived from plants.. phytosterols : Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond. | 2.15 | 1 | 0 | | |
22,26-azasterol
22,26-azasterol: a cholestanol analog with a 6-membered aza ring side chain; structure given in first source | 3.11 | 5 | 0 | | |