Compounds > antazirine

Page last updated: 2024-12-11

antazirine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

antazirine: RN refers to (4Z)-isomer; isolated from Dysidea fragilis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	6444313
CHEMBL ID	541998
CHEBI ID	183130
MeSH ID	M0254956

Synonyms (9)

Synonym
CHEBI:183130
170554-75-3
methyl (2s)-3-[(1e)-13,13-dibromotrideca-1,12-dienyl]-2h-azirine-2-carboxylate
antazirine
LMSP01080044
s-antazirine
methyl 3-(13,13-dibromotrideca-1e,12-dienyl)-2h-azirine-2s-carboxylate
(+)-(e)-antazirine
CHEMBL541998

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
alpha-amino acid ester	The amino acid ester derivative obtained the formal condensation of an alpha-amino acid with an alcohol.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (9)

Assay ID	Title	Year	Journal	Article
AID464151	Antifungal activity against Candida glabrata at 64 ug by broth microdilution method	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
AID464155	Cytotoxicity against human HCT116 cells	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
AID464150	Antifungal activity against fluconazole-resistant Candida albicans 96-489 at 64 ug by broth microdilution method	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
AID464152	Antifungal activity against fluconazole-resistant Candida krusei at 64 ug by broth microdilution method	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
AID464148	Antifungal activity against fluconazole-resistant Candida albicans UCD-FRI at 64 ug by broth microdilution method	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
AID464149	Antifungal activity against Candida albicans ATCC 14503 at 64 ug by broth microdilution method	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
AID464153	Antifungal activity against Cryptococcus neoformans var. grubii at 64 ug by broth microdilution method	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
AID432749	Cytotoxicity against human HCT116 cells	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Aziridine alkaloids as potential therapeutic agents.
AID464154	Antifungal activity against Cryptococcus neoformans var. gatti at 64 ug by broth microdilution method	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	3.14	1	0	mitomycin	alkylating agent; antineoplastic agent
aziridine [no description available]	3.14	1	0	azacycloalkane; aziridines; saturated organic heteromonocyclic parent	alkylating agent
porfiromycin Porfiromycin: Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties.	3.14	1	0
mitomycin a mitomycin A: RN given refers to (1aS-(1aalpha,8beta,8aalpha,8balpha))-isomer; structure given in first source. mitomycin A : A member of the family of mitomycins that exhibits antibiotic and antitumour properties as well as a high level of toxicity.	3.14	1	0	ether; mitomycin	alkylating agent; antimicrobial agent; antineoplastic agent; toxin
imiphos imiphos: structure	3.14	1	0
n-methylmitomycin a [no description available]	3.14	1	0
azicemicin a azicemicin A: structure given in first source; isolated from Amycolatopsis	3.14	1	0
24,25-iminolanosterol 24,25-iminolanosterol: structure given in first source	3.14	1	0
sphingosine sphing-4-enine : A sphingenine in which the C=C double bond is located at the 4-position.. sphingenine : A 2-aminooctadecene-1,3-diol having (2S,3R)-configuration.. sphingoid : Sphinganine, its homologs and stereoisomers, and the hydroxy and unsaturated derivatives of these compounds.. 2-aminooctadec-4-ene-1,3-diol : A 2-aminooctadecene-1,3-diol having its double bond at position 4.	2.05	1	0	sphing-4-enine	human metabolite; mouse metabolite