Compounds > n-methylmitomycin a
Page last updated: 2024-11-07

n-methylmitomycin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID159845
CHEMBL ID102817
MeSH IDM0063394

Synonyms (18)

Synonym
18209-14-8
mitomycin f
n-methylmitomycin a
azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-1,5-dimethyl-, (1as-(1aalpha,8beta,8aalpha,8balpha))-
azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-6,8a-alpha-dimethoxy-1,5-dimethyl-8-(hydroxymethyl)-, carbamate (ester)
CHEMBL102817
n-methyl-mitomycin a
goq83s599k ,
unii-goq83s599k
azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-1,5-dimethyl-, (1as,8s,8ar,8bs)-
FMMDHGNWABITNT-JZWICRQDSA-N
azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-1,5-dimethyl-, (1as,8s,8ar,8bs)-
AKOS030241636
n-methyl mitomycin a
[(4s,6s,7r,8s)-7,11-dimethoxy-5,12-dimethyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
(6,8a-dimethoxy-1,5-dimethyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl hydrogen carbonimidate
DTXSID40939522
Q27279211
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (34)

Assay IDTitleYearJournalArticle
AID1149679Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as mouse survival at 1.6 mg/kg/day administered qd on day 1 and 5 measured on day 301977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID432750Toxicity in ip dosed ddY mouse bearing mouse S180 cells2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID1149672Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as mouse survival at 1.6 mg/kg/day administered qd on day 1 and 5 measured on day 51977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149674Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as mouse survival at 0.4 mg/kg/day administered qd on day 1 and 5 measured on day 51977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149677Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as mouse survival at 6.4 mg/kg/day administered qd on day 1 and 5 measured on day 51977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID11333350% inhibition of solid tumor growth (Sarcoma 180 cells) in mice1995Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
Synthesis and antitumor activity of various 6-demethylmitomycins and 6-demethyl-6-halomitomycins.
AID432751Antitumor activity against mouse S180 cells implanted in ip dosed ddY mouse assessed as tumor volume after 7 days2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID119966Optimal dose was measured against sarcoma 180 cell in mice1995Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
Synthesis and antitumor activity of various 6-demethylmitomycins and 6-demethyl-6-halomitomycins.
AID227069Inhibition of HeLa S3 cell growth relative to mitomycin C action (ratio of IC50 values)1995Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
Synthesis and antitumor activity of various 6-demethylmitomycins and 6-demethyl-6-halomitomycins.
AID1149650Induction of lambda phage lytic activity in Escherichia coli W1709(lambda) assessed as ratio of plaques in treated culture to control at 0.0125 ug/ml preincubated for 90 mins followed by heart infusion broth and glucose addition measured after 120 mins1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149684Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as mouse survival at 6.4 mg/kg/day administered qd on day 1 and 5 measured on day 301977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149651Induction of lambda phage lytic activity in Escherichia coli W1709(lambda) assessed as ratio of plaques in treated culture to control at 0.003 ug/ml preincubated for 90 mins followed by heart infusion broth and glucose addition measured after 120 mins1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149667Toxicity in CDF1 mouse allografted with mouse P388 cells assessed as change in weight at 0.4 mg/kg/day administered qd on day 1 and 5 (Rvb = 3.4 g)1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID120904T/C value was measured as tumor volume in the treated versus control mice.1995Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
Synthesis and antitumor activity of various 6-demethylmitomycins and 6-demethyl-6-halomitomycins.
AID1149665Toxicity in CDF1 mouse allografted with mouse P388 cells assessed as change in weight at 1.6 mg/kg/day administered qd on day 1 and 5 (Rvb = 3.4 g)1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149671Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as mouse survival at 3.2 mg/kg/day administered qd on day 1 and 5 measured on day 51977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149648Induction of lambda phage lytic activity in Escherichia coli W1709(lambda) assessed as ratio of plaques in treated culture to control at 0.2 ug/ml preincubated for 90 mins followed by heart infusion broth and glucose addition measured after 120 mins1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149653Toxicity in Escherichia coli W1709(lambda) at 0.8 ug/ml1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149659Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as effect on median survival time at 0.8 mg/kg/day administered qd on day 1 and 5 relative to control1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149670Toxicity in CDF1 mouse allografted with mouse P388 cells assessed as change in weight at 6.4 mg/kg/day administered qd on day 1 and 5 (Rvb = 3.4 g)1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149664Toxicity in CDF1 mouse allografted with mouse P388 cells assessed as change in weight at 3.2 mg/kg/day administered qd on day 1 and 5 (Rvb = 3.4 g)1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149666Toxicity in CDF1 mouse allografted with mouse P388 cells assessed as change in weight at 0.8 mg/kg/day administered qd on day 1 and 5 (Rvb = 3.4 g)1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149663Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as effect on median survival time at 6.4 mg/kg/day administered qd on day 1 and 5 relative to control1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149681Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as mouse survival at 0.4 mg/kg/day administered qd on day 1 and 5 measured on day 301977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149661Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as effect on median survival time at 0.2 mg/kg/day administered qd on day 1 and 5 relative to control1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149668Toxicity in CDF1 mouse allografted with mouse P388 cells assessed as change in weight at 0.2 mg/kg/day administered qd on day 1 and 5 (Rvb = 3.4 g)1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149680Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as mouse survival at 0.8 mg/kg/day administered qd on day 1 and 5 measured on day 301977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149658Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as effect on median survival time at 1.6 mg/kg/day administered qd on day 1 and 5 relative to control1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149657Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as effect on median survival time at 3.2 mg/kg/day administered qd on day 1 and 5 relative to control1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149660Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as effect on median survival time at 0.4 mg/kg/day administered qd on day 1 and 5 relative to control1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149682Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as mouse survival at 0.2 mg/kg/day administered qd on day 1 and 5 measured on day 301977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149675Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as mouse survival at 0.2 mg/kg/day administered qd on day 1 and 5 measured on day 51977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149649Induction of lambda phage lytic activity in Escherichia coli W1709(lambda) assessed as ratio of plaques in treated culture to control at 0.05 ug/ml preincubated for 90 mins followed by heart infusion broth and glucose addition measured after 120 mins1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
AID1149673Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as mouse survival at 0.8 mg/kg/day administered qd on day 1 and 5 measured on day 51977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (50.00)18.7374
1990's2 (33.33)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.23 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.18 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetic acid
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.		1.9610monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		8.9940mitomycinalkylating agent;
antineoplastic agent
aziridine
[no description available]		3.1410azacycloalkane;
aziridines;
saturated organic heteromonocyclic parent		alkylating agent
porfiromycin
Porfiromycin: Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties.		3.7830
mitomycin a
mitomycin A: RN given refers to (1aS-(1aalpha,8beta,8aalpha,8balpha))-isomer; structure given in first source. mitomycin A : A member of the family of mitomycins that exhibits antibiotic and antitumour properties as well as a high level of toxicity.		8.9940ether;
mitomycin		alkylating agent;
antimicrobial agent;
antineoplastic agent;
toxin
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		1.9610dihydrogen
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		1.9610benzenes;
phenyl acetates
imiphos
imiphos: structure		3.1410
azicemicin a
azicemicin A: structure given in first source; isolated from Amycolatopsis		3.1410
24,25-iminolanosterol
24,25-iminolanosterol: structure given in first source		3.1410
mitosene
mitosene: structure given in first source		1.9610
antazirine
antazirine: RN refers to (4Z)-isomer; isolated from Dysidea fragilis; structure in first source		3.1410alpha-amino acid ester
ConditionIndicatedRelationship StrengthStudiesTrials
Experimental Leukemia
[description not available]		01.9510
Sarcoma 180
An experimental sarcoma of mice.		01.9810