Compounds > azicemicin a
Page last updated: 2024-12-08

azicemicin a

Description

azicemicin A: structure given in first source; isolated from Amycolatopsis [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID160393
CHEMBL ID550128
MeSH IDM0225823

Synonyms (7)

Synonym
154163-93-6
azicemicin a
benz(a)anthracene-1,6(2h,5h)-dione, 3,4,4a,12b-tetrahydro-9,12-dimethoxy-3-(1-methyl-2-aziridinyl)-3,7,8,10,12b-pentahydroxy-
CHEMBL550128
3,7,8,10,12b-pentahydroxy-9,12-dimethoxy-3-(1-methylaziridin-2-yl)-3,4,4a,12b-tetrahydrotetraphene-1,6(2h,5h)-dione
3,7,8,10,12b-pentahydroxy-9,12-dimethoxy-3-(1-methylaziridin-2-yl)-2,4,4a,5-tetrahydrobenzo[a]anthracene-1,6-dione
DTXSID60934938
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (34)

Assay IDTitleYearJournalArticle
AID432888Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 52009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432894Antimicrobial activity against Shigella dysenteriae JS1 19102009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432875Antimicrobial activity against Escherichia coli K-12 MLI6292009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432876Antimicrobial activity against Escherichia coli BEM112009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432869Antimicrobial activity against Bacillus anthracis2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432886Antimicrobial activity against Staphylococcus aureus FDA209P2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432874Antimicrobial activity against Escherichia coli K-122009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432883Antimicrobial activity against Providencia rettgeri GN4662009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432757Antimicrobial activity against rifamycin-resistant Mycobacterium smegmatis ATCC 6072009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432872Antimicrobial activity against Bacillus subtilis PCI 2192009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432756Antimicrobial activity against Mycobacterium vaccae ATCC 154832009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432880Antimicrobial activity against Proteus vulgaris OX192009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432745Antimicrobial activity against Micrococcus luteus FDA162009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432881Antimicrobial activity against Proteus mirabilis IFM OM-92009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432754Antimicrobial activity against Escherichia coli NIHJ2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432892Antimicrobial activity against Salmonella typhi T-632009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432891Antimicrobial activity against Micrococcus luteus PCI 10012009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432896Antimicrobial activity against Salmonella typhi JS117462009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432870Antimicrobial activity against Bacillus cereus ATCC 107022009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432884Antimicrobial activity against Pseudomonas aeruginosa A32009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432871Antimicrobial activity against Bacillus subtilis NRRL B-5582009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432878Antimicrobial activity against Escherichia coli BE11862009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432887Antimicrobial activity against Staphylococcus aureus Smith2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432879Antimicrobial activity against Klebsiella pneumoniae PCI6022009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432893Antimicrobial activity against Salmonella enteritidis 18912009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432877Antimicrobial activity against Escherichia coli BE11262009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432744Antimicrobial activity against Staphylococcus aureus MS96102009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432755Antimicrobial activity against Mycobacterium smegmatis ATCC 6072009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432873Antimicrobial activity against Corynebacterium bovis 18102009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432885Antimicrobial activity against Pseudomonas aeruginosa GN3152009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432882Antimicrobial activity against Providencia rettgeri GN3112009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432890Antimicrobial activity against Micrococcus luteus IFO 33332009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432895Antimicrobial activity against Shigella flexneri 4bJS118112009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
AID432889Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate 172009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Aziridine alkaloids as potential therapeutic agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.29 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		3.1410mitomycinalkylating agent;
antineoplastic agent
aziridine
[no description available]		3.5520azacycloalkane;
aziridines;
saturated organic heteromonocyclic parent		alkylating agent
porfiromycin
Porfiromycin: Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties.		3.1410
mitomycin a
mitomycin A: RN given refers to (1aS-(1aalpha,8beta,8aalpha,8balpha))-isomer; structure given in first source. mitomycin A : A member of the family of mitomycins that exhibits antibiotic and antitumour properties as well as a high level of toxicity.		3.1410ether;
mitomycin		alkylating agent;
antimicrobial agent;
antineoplastic agent;
toxin
imiphos
imiphos: structure		3.1410
n-methylmitomycin a
[no description available]		3.1410
24,25-iminolanosterol
24,25-iminolanosterol: structure given in first source		3.1410
antazirine
antazirine: RN refers to (4Z)-isomer; isolated from Dysidea fragilis; structure in first source		3.1410alpha-amino acid ester
ConditionIndicatedRelationship StrengthStudiesTrials
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