Compounds > 2-(4-chlorophenoxy)propionic acid
Page last updated: 2024-11-05

2-(4-chlorophenoxy)propionic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-(4-Chlorophenoxy)propionic acid, also known as clofibric acid, is a synthetic lipid-lowering drug. It is used to treat high cholesterol and triglycerides. Clofibric acid works by stimulating the breakdown of fats in the liver and by reducing the production of cholesterol. It is typically administered orally. Clofibric acid has been studied for its potential to treat a variety of other conditions, including diabetes, cancer, and Alzheimer’s disease. However, it has been associated with a number of side effects, including muscle pain, liver problems, and gallstones. Therefore, it is important to use clofibric acid only under the supervision of a healthcare professional.'

2-(4-chlorophenoxy)propionic acid: RN given refers to parent cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID18703
CHEMBL ID23629
CHEBI ID34603
SCHEMBL ID117259
MeSH IDM0138852

Synonyms (43)

Synonym
nsc-70174
propionic acid, 2-(p-chlorophenoxy)-
propanoic acid, 2-(4-chlorophenoxy)-
4-cpp
.alpha.-(4-chlorophenoxy)propionic acid
2-(4-cpp)
nsc70174
2-(4-chlorophenoxy)propionic acid
2-(p-chlorophenoxy)propionic acid
3307-39-9
NCIOPEN2_003229
CHEMBL23629
chebi:34603 ,
AKOS000103748
FT-0692466
2-(4-chlorophenoxy)propanoic acid
STK864364
BBL002029
AN-329/13156508
nsc 70174
alpha-(4-chlorophenoxy)propionic acid
einecs 221-991-8
(2r)-2-(4-chlorophenoxy)propanoate;2-(4-chlorophenoxy)propionic acid
A821604
EN300-08066
F3034-0105
gtpl4098
s-(-)cpp
AB01328827-02
SCHEMBL117259
AKOS016040191
W-106789
2-(4-chlorophenoxy) propionic acid
mfcd00002647
2-(4-chlorophenoxy) propionic acid 100 microg/ml in acetonitrile
Z56922097
NCGC00337574-01
DTXSID90875865
2-(4-chlorophenoxy)propanoicacid
CS-0183433
AS-14004
A50595
SY082542

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Dose-response curves in which the block of GCl by the S-(-) isomer was evaluated in the presence of the R-(+) isomer (3-10 microM) clearly showed an antagonistic interaction between the two enantiomers, with an increase in the S-(-) concentration for half-maximal block."( Opposite effects of enantiomers of clofibric acid derivative on rat skeletal muscle chloride conductance: antagonism studies and theoretical modeling of two different receptor site interactions.
Bryant, SH; Conte Camerino, D; De Luca, A; Tortorella, V; Tricarico, D; Wagner, R, 1992)		0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
phenoxy herbicideAny member of the class of herbicides whose members contain a phenoxy or substituted phenoxy group.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
monocarboxylic acidAn oxoacid containing a single carboxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID188925Maximum number of spikes elicited by strong depolarizing pulses in rat extensor digitorum longus(EDL) muscle fibers was determined at a concentration of 92 uM1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues.
AID179400Concentration required to block 50% chloride conductance in rat extensor digitorum longus(EDL) muscle fibers1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues.
AID190469Minimal current intensity for a long pulse for a single action potential in rat extensor digitorum longus(EDL) muscle fibers was determined at a concentration of 92 uM1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues.
AID185154Latency was determined in rat extensor digitorum longus(EDL) muscle fibers at a concentration of 92 uM1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues.
AID191075Resting membrane potential determined in rat extensor digitorum longus(EDL) muscle fibers at a concentration of 92 uM1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues.
AID179015Number of fibres over number of preparation sampled was determined at a concentration of 92 uM1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (15.79)18.7374
1990's6 (31.58)18.2507
2000's8 (42.11)29.6817
2010's2 (10.53)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.98 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.54 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.98)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (10.53%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (89.47%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		4.1850halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
phenylacetic acid
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.		1.9610benzenes;
monocarboxylic acid;
phenylacetic acids		allergen;
Aspergillus metabolite;
auxin;
EC 6.4.1.1 (pyruvate carboxylase) inhibitor;
Escherichia coli metabolite;
human metabolite;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite;
toxin
2,4-dichlorophenoxyacetic acid
2,4-Dichlorophenoxyacetic Acid: An herbicide with irritant effects on the eye and the gastrointestinal system.. 2,4-D : A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.		2.420chlorophenoxyacetic acid;
dichlorobenzene		agrochemical;
defoliant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
environmental contaminant;
phenoxy herbicide;
synthetic auxin
9-anthroic acid
9-anthroic acid: RN given refers to unlabeled parent cpd; chloride channel blocker; do not confuse with c-ANCA (anti-neutrophil cytoplasmic antibodies) which is frequently abbreviated as ANCA. 9-anthroic acid : An anthroic acid carrying the carboxy substituent at position 9.		3.1310anthroic acid
clofibrate
angiokapsul: contains clofibrate & insoitolnicotinate		2.6630aromatic ether;
ethyl ester;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
geroprotector;
PPARalpha agonist
clofibric acid
Clofibric Acid: An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.. clofibric acid : A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.		3.2360aromatic ether;
monocarboxylic acid;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
antineoplastic agent;
herbicide;
marine xenobiotic metabolite;
PPARalpha agonist
mecoprop
mecoprop: RN given refers to cpd without isomeric designation; structure. 2-(4-chloro-2-methylphenoxy)propanoic acid : A monocarboxylic acid that is lactic acid in which the hydroxyl hydrogen is replaced by a 4-chloro-2-methylphenyl group.. mecoprop : A racemate comprising equimolar amounts of (R)- and (S)-mecoprop.		1.9610aromatic ether;
monocarboxylic acid;
monochlorobenzenes
2-methyl-4-chlorophenoxyacetic acid
2-Methyl-4-chlorophenoxyacetic Acid: A powerful herbicide used as a selective weed killer.. (4-chloro-2-methylphenoxy)acetic acid : A chlorophenoxyacetic acid that is (4-chlorophenoxy)acetic acid substituted by a methyl group at position 2.		5.91190chlorophenoxyacetic acid;
monochlorobenzenes		environmental contaminant;
phenoxy herbicide;
synthetic auxin
dichlorprop
dichlorprop: RN given refers to parent cpd without isomeric designation; structure. 2-(2,4-dichlorophenoxy)propanoic acid : An aromatic ether that is 2-hydroxypropanoic acid in which the hydroxy group at position 2 has been converted to its 2,4-dichlorophenyl ether.. dichlorprop : A racemate comprising equimolar amounts of (R)- and (S)-dichlorprop. It is widely used as a herbicide for killing annual and broad leaf weeds. Only the R-enantiomer has herbicidal activity; the S-enantiomer is inactive.		2.0810aromatic ether;
dichlorobenzene;
monocarboxylic acid
2-phenoxypropanoic acid
2-phenoxypropanoic acid: structure in first source		2.0810aromatic ether;
carboxylic acid
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		2.0810dihydrogen
4-chlorophenoxyacetic acid
4-chlorophenoxyacetic acid: RN given refers to parent cpd; structure. (4-chlorophenoxy)acetic acid : A chlorophenoxyacetic acid that is phenoxyacetic acid carrying a chloro substituent at position 4.		1.9610chlorophenoxyacetic acid;
monochlorobenzenes		phenoxy herbicide
2-(4-chlorophenoxy)butyric acid
2-(4-chlorophenoxy)butyric acid: structure given in first source		2.6630
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid: An inhibitor of anion conductance including band 3-mediated anion transport.		2.0210
clay
Clay: A naturally-occurring rock or soil constituent characterized by particles with a diameter of less than 0.005 mm. It is composed primarily of hydrous aluminum silicates, trace amounts of metal OXIDES, and organic matter.		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Muscular Dystrophy, Animal
MUSCULAR DYSTROPHY that occurs in VERTEBRATE animals.		0210
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		02.3920
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9710
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9710