Page last updated: 2024-12-08
2-(4-chlorophenoxy)butyric acid
Description
2-(4-chlorophenoxy)butyric acid, also known as **MCPA**, is a synthetic auxin herbicide. Auxins are plant hormones that play a crucial role in regulating plant growth and development.
**Importance in research:**
* **Mode of action:** MCPA disrupts plant growth by mimicking the action of natural auxins. It disrupts normal cell division and elongation, leading to plant death. This makes MCPA an important tool for studying the role of auxins in plant development.
* **Herbicidal activity:** MCPA is widely used as a herbicide for controlling broadleaf weeds in various crops. Its effectiveness and selectivity make it a valuable research subject for developing new and more efficient herbicides.
* **Environmental impact:** MCPA is relatively persistent in the environment and can accumulate in soil and water. Research is ongoing to understand its environmental fate and potential risks to aquatic organisms and human health.
* **Bioremediation:** MCPA has been investigated for its potential in bioremediation strategies. Certain microorganisms can degrade MCPA, making it a target for bioremediation of contaminated sites.
* **Crop protection:** MCPA's selective herbicide activity makes it crucial for developing strategies to protect crops from weed competition. Research explores new formulations and application methods to improve its efficacy and minimize environmental impact.
* **Plant physiology:** MCPA can be used as a tool to study various physiological processes in plants, such as phototropism (bending towards light), gravitropism (bending towards gravity), and root development.
In summary, 2-(4-chlorophenoxy)butyric acid (MCPA) is a significant compound in research due to its diverse applications in studying plant growth, developing herbicides, understanding environmental impact, and exploring bioremediation and crop protection strategies.
2-(4-chlorophenoxy)butyric acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 151501 |
| CHEMBL ID | 23477 |
| SCHEMBL ID | 3028298 |
| MeSH ID | M0151274 |
Synonyms (25)
| Synonym |
|---|
| butanoic acid,2-(4-chlorophenoxy)- |
| STK501060 |
| 2-(4-chlorophenoxy)butanoic acid |
| CHEMBL23477 |
| AKOS000103672 |
| 2-(4-chlorophenoxy)butyric acid |
| BBL002691 |
| 10310-19-7 |
| butanoic acid, 2-(4-chlorophenoxy)- |
| 2-(p-chlorophenoxy)butyric acid |
| 34385-92-7 |
| AKOS016345013 |
| s-(-)cpb |
| gtpl4097 |
| AB01322784-02 |
| SCHEMBL3028298 |
| p-chlorophenoxybutyric acid |
| CEJKAKCQVUWNNA-UHFFFAOYSA-N |
| (2rs)-2-(4-chlorophenoxy)butyric acid |
| mfcd02295734 |
| CS-0206124 |
| VS-01167 |
| NCGC00327569-01 |
| DTXSID00908198 |
| EN300-228628 |
Research Excerpts
Dosage Studied
Bioassays (6)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID191076 | Resting membrane potential in rat extensor digitorum longus(EDL) muscle fibers was determined at a concentration of 92 uM | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
| Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues. |
| AID179400 | Concentration required to block 50% chloride conductance in rat extensor digitorum longus(EDL) muscle fibers | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
| Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues. |
| AID190469 | Minimal current intensity for a long pulse for a single action potential in rat extensor digitorum longus(EDL) muscle fibers was determined at a concentration of 92 uM | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
| Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues. |
| AID188922 | Maximum number of spikes elicited by strong depolarizing pulses in rat extensor digitorum longus muscle fibers was determined at a concentration of 92 uM | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
| Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues. |
| AID179015 | Number of fibres over number of preparation sampled was determined at a concentration of 92 uM | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
| Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues. |
| AID185153 | Latency in rat extensor digitorum longus(EDL) muscle fibers was determined at a concentration of 92 uM | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
| Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.63
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.63 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.42 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |