Compounds > 1-bromo-2,4-dinitrobenzene
Page last updated: 2024-11-05

1-bromo-2,4-dinitrobenzene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-bromo-2,4-dinitrobenzene is a yellow crystalline solid that is used as an intermediate in the synthesis of other organic compounds. It is also a potential environmental contaminant and has been shown to be toxic to aquatic organisms. The compound is known to be a skin irritant and has been linked to skin sensitization. Research on 1-bromo-2,4-dinitrobenzene focuses on its synthesis, reactivity, and potential environmental impacts. Studies investigate its biological effects, its interactions with various substrates, and its potential for degradation and detoxification.'

2,4-dinitrobromobenzene : An organobromine compound that is bromobenzene substituted at C-2 and -4 with nitro groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID11441
CHEBI ID58999
SCHEMBL ID399325
MeSH IDM0058198

Synonyms (37)

Synonym
2-bromo-1,5-dinitrobenzene
dnbb
CHEBI:58999
4ms3ftw380 ,
unii-4ms3ftw380
4-bromo-1,3-dinitrobenzene
2,4-dinitrobromobenzene
nsc-3808
nsc3808
584-48-5
1-bromo-2,4-dinitrobenzene
benzene, 1-bromo-2,4-dinitro-
7238-15-5
2,4-dinitrophenyl bromide
ai3-01803
ccris 1801
o,p-dinitrophenyl bromide
nsc 3808
einecs 209-539-8
1-bromo-2,4-dinitrobenzene, 97%
AC-10400
D2701
AKOS005258872
FT-0632441
bromo-2,4-dinitrobenzene
2,4-dinitro-bromobenzene
bromo-2,4-dinitrobenzene, 1-
DTXSID3060403
SCHEMBL399325
2, 4-dinitrobromobenzene
W-203191
1-bromo-2,4-dinitro-benzene
mfcd00041873
AS-58751
Q27126388
1-bromo-2.4-dinitrobenzene
BR1306

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" These findings appear to conflict with the hypothesis that a strictly dose-additive combined effect will be observed for agents sharing a single molecular site of toxic action within the organism."( Time dependence in mixture toxicity with soft electrophiles: 1. Combined effects of selected SN2- and SNAr-reactive agents with a nonpolar narcotic.
Dawson, DA; Gagan, EM; Hull, MW; Pöch, G; Schultz, TW, 2007)		0.34

Dosage Studied

ExcerptRelevanceReference
" The mercapturic acid conjugate in rats was also studied by collection of urine of rats dosed with radioactive DNBB by intraperitoneal injection."( Glutathione and mercapturic acid conjugations in the metabolism of 2,4-dinitrobromobenzene.
Chen, KC; Dorough, HW, 1980)		0.26
" By incorporating TDT values, shapes of the dose-response curves, chemical reactivity data with thiol, reactive mechanisms for the soft electrophiles, and quantitative structure activity relationship information on whether the toxicity of the individual soft electrophiles did or did not exceeded that predicted for baseline narcosis, the results suggested that the alpha-halogens elicited two toxic effects at the concentrations tested (reactivity and narcotizing effects), whereas toxicity induced by the halogenated dinitrobenzenes was essentially limited to reactive effects."( Time dependence in mixture toxicity with soft electrophiles: 1. Combined effects of selected SN2- and SNAr-reactive agents with a nonpolar narcotic.
Dawson, DA; Gagan, EM; Hull, MW; Pöch, G; Schultz, TW, 2007)		0.34
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
organobromine compoundA compound containing at least one carbon-bromine bond.
C-nitro compoundA nitro compound having the nitro group (-NO2) attached to a carbon atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.27 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index35.70 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (32.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dinitrochlorobenzene
Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.. 1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.		2.9240C-nitro compound;
monochlorobenzenes		allergen;
epitope;
sensitiser
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		1.9910aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
dinitrofluorobenzene
Dinitrofluorobenzene: Irritants and reagents for labeling terminal amino acid groups.. 1-fluoro-2,4-dinitrobenzene : The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.		2.6930C-nitro compound;
organofluorine compound		agrochemical;
allergen;
chromatographic reagent;
EC 2.7.3.2 (creatine kinase) inhibitor;
protein-sequencing agent;
spectrophotometric reagent
isopropyl methyl ketone
[no description available]		2.0310ketone
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		1.9510acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
3-chloro-2,4-pentanedione
3-chloro-2,4-pentanedione: structure in first source		2.0310
dinitrobenzenes
Dinitrobenzenes: Benzene derivatives which are substituted with two nitro groups in the ortho, meta or para positions.		3.0950
ConditionIndicatedRelationship StrengthStudiesTrials