yoda-1 and Heart-Failure

The beating heart possesses the intrinsic ability to adapt cardiac output to changes in mechanical load. The century-old Frank-Starling law and Anrep effect have documented that stretching the heart during diastolic filling increases its contractile force. However, the molecular mechanotransduction mechanism and its impact on cardiac health and disease remain elusive. Here we show that the mechanically activated Piezo1 channel converts mechanical stretch of cardiomyocytes into Ca

Topics: Animals; Arrhythmias, Cardiac; Calcium; Calcium Signaling; Cardiomyopathies; Gene Deletion; Heart Failure; Heart Function Tests; Homeostasis; Ion Channels; Mechanotransduction, Cellular; Mice, Knockout; Myocardium; Myocytes, Cardiac; Organ Specificity; Pyrazines; Reactive Oxygen Species; Thiadiazoles; Up-Regulation