yoda-1 and Glaucoma

The trabecular meshwork (TM) constitutes the main pathway for aqueous humor drainage and is exposed to complex intraocular pressure fluctuations. The mechanism of homeostasis in which TM senses changes in intraocular pressure and leads to normal levels of outflow resistance is not yet well understood. Previous reports have shown that Piezo1, a mechanically-activated cation channel, is expressed in TM and isolated TM cells. Therefore, we tested hypothesis that Piezo1 may function in response to membrane tension and stretch in TM. In human trabecular meshwork (hTM) cells, PIEZO1 was showed to be abundantly expressed, and Piezo1 agonist Yoda1 and mechanical stretch caused a Piezo1-dependent Ca

Topics: Aqueous Humor; Biomechanical Phenomena; Calcium; Calcium Channels; Cells, Cultured; Dinoprostone; Female; Gene Expression; Glaucoma; Homeostasis; Humans; Intraocular Pressure; Ion Channels; Male; Mechanoreceptors; Middle Aged; Primary Cell Culture; Pyrazines; Thiadiazoles; Trabecular Meshwork