positive regulation of cell-cell adhesion mediated by integrin

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin. [GOC:add]

Positive regulation of cell-cell adhesion mediated by integrin is a complex process involving multiple signaling pathways and molecular interactions. Integrins are transmembrane receptors that play a crucial role in cell-cell and cell-matrix adhesion. They bind to extracellular matrix proteins, such as fibronectin, collagen, and laminin, as well as to other cell surface molecules. This binding triggers intracellular signaling cascades that ultimately lead to the formation of stable adhesive contacts between cells.

The positive regulation of this process can occur at various levels, including:

1. **Integrin activation:** Integrins exist in an inactive state, which needs to be activated to bind to their ligands. This activation can be triggered by various factors, such as mechanical forces, growth factors, and other signaling molecules. Activation involves conformational changes in the integrin molecule that expose its ligand-binding site.
2. **Clustering and assembly of integrins:** Once activated, integrins cluster together at the cell surface, forming focal adhesions. These focal adhesions are specialized structures that link the cytoskeleton to the extracellular matrix. The clustering and assembly of integrins involve the interaction of integrins with various intracellular adaptor proteins, such as talin, vinculin, and paxillin.
3. **Regulation of downstream signaling pathways:** Upon integrin binding to their ligands, downstream signaling pathways are activated. These pathways involve various protein kinases, such as focal adhesion kinase (FAK), and GTPases, such as Rho and Rac. These pathways regulate cytoskeletal rearrangements, gene expression, and cell survival.

The overall effect of positive regulation of cell-cell adhesion mediated by integrin is to promote cell adhesion, migration, and differentiation. This process is essential for various biological functions, such as tissue development, wound healing, and immune responses. Disruptions in this process can lead to various diseases, including cancer, inflammation, and cardiovascular disease.'
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Proteins (1)

Compounds (1)