vaticanol-c and Colonic-Neoplasms

vaticanol-c has been researched along with Colonic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for vaticanol-c and Colonic-Neoplasms

Article	Year
Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C. Carcinogenesis, 2003, Volume: 24, Issue:9 Twenty resveratrol (3,5,4'-trihydroxystilbene) (Res) derivatives, which were isolated from stem bark of Vatica rassak (Dipterocarpaceae), were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Among them, seven compounds displayed marked cytotoxicity. Vaticanol C (Vat C) as a major component induced a considerable cytotoxicity in all cell lines tested and exhibited growth suppression in colon cancer cell lines at low dose. Vat C caused two cell lines (SW480 and HL60) to induce cell death at four to seven times lower concentrations, compared with Res. The growth suppression by Vat C was found to be due to apoptosis, which was assessed by morphological findings (nuclear condensation and fragmentation) and DNA ladder formation in the colon cancer cell lines. The apoptosis in SW480 colon cancer cells was executed by the activation of caspase-3, which was shown by western blot and apoptosis inhibition assay. Furthermore, the mitochondrial membrane potential of apoptotic SW480 cells after 12 h treatment with Vat C was significantly lost, and concurrently the cytochrome c release and activation of caspase-9 were also detected by western blot analysis. Over-expression of Bcl-2 protein in SW480 cells significantly prevented the cell death induced by Vat C. Taken together, the findings presented here indicate that Vat C induced marked apoptosis in malignant cells mainly by affecting mitochondrial membrane potential. Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspases; Cell Division; Colonic Neoplasms; Enzyme Activation; Humans; Membrane Potentials; Mitochondria; Resveratrol; Stilbenes; Tumor Cells, Cultured	2003
Vaticanol C, a novel resveratrol tetramer, inhibits cell growth through induction of apoptosis in colon cancer cell lines. Biological & pharmaceutical bulletin, 2002, Volume: 25, Issue:1 A novel resveratrol tetramer, vaticanol C, isolated from the stem bark of Vatica rassak markedly suppressed cell growth through induction of apoptosis, which was characterized by nuclear changes and DNA ladder formation, in three different human colon cancer cell lines. Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Colonic Neoplasms; DNA, Neoplasm; Humans; Molecular Weight; Plant Epidermis; Resveratrol; Stilbenes; Tumor Cells, Cultured	2002

Article

Year

Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C.

Carcinogenesis, 2003, Volume: 24, Issue:9

Twenty resveratrol (3,5,4'-trihydroxystilbene) (Res) derivatives, which were isolated from stem bark of Vatica rassak (Dipterocarpaceae), were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Among them, seven compounds displayed marked cytotoxicity. Vaticanol C (Vat C) as a major component induced a considerable cytotoxicity in all cell lines tested and exhibited growth suppression in colon cancer cell lines at low dose. Vat C caused two cell lines (SW480 and HL60) to induce cell death at four to seven times lower concentrations, compared with Res. The growth suppression by Vat C was found to be due to apoptosis, which was assessed by morphological findings (nuclear condensation and fragmentation) and DNA ladder formation in the colon cancer cell lines. The apoptosis in SW480 colon cancer cells was executed by the activation of caspase-3, which was shown by western blot and apoptosis inhibition assay. Furthermore, the mitochondrial membrane potential of apoptotic SW480 cells after 12 h treatment with Vat C was significantly lost, and concurrently the cytochrome c release and activation of caspase-9 were also detected by western blot analysis. Over-expression of Bcl-2 protein in SW480 cells significantly prevented the cell death induced by Vat C. Taken together, the findings presented here indicate that Vat C induced marked apoptosis in malignant cells mainly by affecting mitochondrial membrane potential.

Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspases; Cell Division; Colonic Neoplasms; Enzyme Activation; Humans; Membrane Potentials; Mitochondria; Resveratrol; Stilbenes; Tumor Cells, Cultured

2003

Vaticanol C, a novel resveratrol tetramer, inhibits cell growth through induction of apoptosis in colon cancer cell lines.

Biological & pharmaceutical bulletin, 2002, Volume: 25, Issue:1

A novel resveratrol tetramer, vaticanol C, isolated from the stem bark of Vatica rassak markedly suppressed cell growth through induction of apoptosis, which was characterized by nuclear changes and DNA ladder formation, in three different human colon cancer cell lines.

Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Colonic Neoplasms; DNA, Neoplasm; Humans; Molecular Weight; Plant Epidermis; Resveratrol; Stilbenes; Tumor Cells, Cultured

2002