Compounds > u 25166
Page last updated: 2024-10-15

u 25166

Cross-References

ID SourceID
PubMed CID135415622
CHEMBL ID80800
SCHEMBL ID1687020
MeSH IDM0063837

Synonyms (46)

Synonym
CHEMBL80800
AKOS005444185
einecs 228-623-5
u 25 166
w53cvg2um9 ,
u 25166
u-25-166
unii-w53cvg2um9
nsc 41319
2-amino-5-bromo-6-methylpyrimidin-4(1h)-one
6307-35-3
nsc41319
nsc-41319
2-amino-5-bromo-6-methyl-4(3h)-pyrimidinone
2-amino-5-bromo-4-methyl-1h-pyrimidin-6-one
2-amino-5-bromo-6-methyl-4-pyrimidinol
2-amino-5-bromo-6-methyl-pyrimidin-4-ol
abmp
2-amino-5-bromo-4-hydroxy-6-methylpyrimidine
u-25166
2-amino-5-bromo-6-methylpyrimidin-4-ol
2-amino-5-bromo-6-methyl-4-pyrimidinol, 97%
HMS1608O07
2-amino-5-bromo-6-methyl-1h-pyrimidin-4-one
AKOS009159216
CCG-15417
BP-12353
FT-0611147
SCHEMBL1687020
4(1h)-pyrimidinone, 2-amino-5-bromo-6-methyl-
2-amino-5-bromo-6-methyl-3,4-dihydropyrimidin-4-one
HMS3428I03
DTXSID70212395
2-amino-5-bromo-6-methylpyrimidin-4(3h)-one
F0346-1547
SR-01000396923-1
sr-01000396923
mfcd00006092
CS-0204853
D95459
4(3h)-pyrimidinone, 2-amino-5-bromo-6-methyl-
u25166
4-pyrimidinol, 2-amino-5-bromo-6-methyl-
SB58261
BS-22840
A868252
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID114538Tested for in vivo antiviral activity against semliki forest virus in mice after intraperitoneal administration1980Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
5-substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents.
AID99827Serum interferon response from a single ip administration of 800 mg/kg employing a plaque-reduction assay.(VSV on L929 cells)1980Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
5-substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents.
AID83910Protective index was measured on herpes simplex virus type 1(HSV-1) infected mice at 150 mg/kg/day1980Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
5-substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (63.64)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cytosine
[no description available]		2.6530aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
tilorone
Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.. tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.		1.9510aromatic ether;
diether;
fluoren-9-ones;
tertiary amino compound		anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
interferon inducer;
nicotinic acetylcholine receptor agonist
hydrocortisone acetate
hydrocortisone acetate: RN given refers to cpd without isomeric designation		1.9610cortisol ester;
tertiary alpha-hydroxy ketone
cytarabine
[no description available]		1.9610beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
methylprednisolone
Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.. 6alpha-methylprednisolone : The 6alpha-stereoisomer of 6-methylprednisolone.		1.96106-methylprednisolone;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		adrenergic agent;
anti-inflammatory drug;
antiemetic;
environmental contaminant;
neuroprotective agent;
xenobiotic
alprostadil
[no description available]		1.9610prostaglandins Eanticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent
15(s)-15-methylprostaglandin e1
15(S)-15-methylprostaglandin E1: stable deriv of PGE1; RN given refers to (11 alpha,13E,15S)-isomer		1.9610prostanoid
2-amino-5-iodo-6-phenyl-4-pyrimidinone
[no description available]		2.8740
bropirimine
[no description available]		2.8740pyrimidines
pyrimidinones
Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.		2.3620
ConditionIndicatedRelationship StrengthStudiesTrials
Arbovirus Infections
Infections caused by arthropod-borne viruses, general or unspecified.		01.9510
Herpes Simplex Virus Infection
[description not available]		01.9510
Herpes Simplex
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)		01.9510
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Experimental Leukemia
[description not available]		01.9510
Viral Diseases
[description not available]		02.3620
Virus Diseases
A general term for diseases caused by viruses.		02.3620
Malignant Melanoma
[description not available]		01.9510
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		01.9510
Infections, Listeria
[description not available]		01.9610