trifenmorph

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Trifenmorph, also known as tridemorph, is a fungicide used to control powdery mildew in various crops. It is synthesized through a series of reactions involving chlorination, alkylation, and condensation. Trifenmorph inhibits the biosynthesis of ergosterol, a crucial component of fungal cell membranes, leading to disruption of cell growth and development. It exhibits both preventive and curative action against powdery mildew. Due to its effectiveness and relatively low toxicity to mammals, trifenmorph is widely used in agriculture. However, concerns regarding its potential environmental impact and the emergence of resistant fungal strains have led to ongoing research on its mode of action, alternative fungicides, and sustainable practices.'

trifenmorph: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	14993
CHEMBL ID	2086832
CHEBI ID	82264
SCHEMBL ID	435727
MeSH ID	M0042375

Synonyms (36)

Synonym
unii-h1il51k9cw
h1il51k9cw ,
trifenmorph [iso:bsi]
caswell no. 898a
wl 8008
einecs 215-812-2
triphenmorphe
ai3-51843
morpholine, n-trityl-
n-tritylmorpholine
frescon
n-(triphenyl-methyl)morpholine
epa pesticide chemical code 498300
morpholine, 4-(triphenylmethyl)-
morpholine, 4-trityl-
trifenmorph
4-tritylmorpholine
hsdb 1785
shell wl 8008
brn 1223254
4-(triphenylmethyl)morpholine
NCGC00160549-01
AKOS003382578
C19144
1420-06-0
chebi:82264 ,
CHEMBL2086832
trifenmorph [hsdb]
trifenmorph [mart.]
trifenmorph [mi]
trifenmorph [iso]
SCHEMBL435727
n-(triphenylmethyl)morpholine
DTXSID6042492
4-tritylmorpholine #
Q27155848

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" This order was the same in oligocalcic water with Echinogammarus berilloni; with Gammarus pulex, CuCl2 was more toxic than Triphenmorph."	( [Comparative study of the toxicity of metal chlorides and a synthetic organic molluscacide, N-tritylmorpholine, in 2 fresh-water amphipods, Gammarus pulex and Echinogammarus berilloni]. Debord, J; Penicaut, B; Vincent, M, 1986)	0.27

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
morpholines	Any compound containing morpholine as part of its structure.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID684467	Inhibition of apolipoprotein E production in human CCF-STTG1 cells at 10 uM after 24 hrs by ELISA relative to vehicle-treated control	2012	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19	Design, synthesis and identification of a new class of triarylmethyl amine compounds as inhibitors of apolipoprotein E production.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	12 (85.71)	18.7374
1990's	1 (7.14)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (7.14)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.52

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	16.52 (24.57)
Research Supply Index	2.77 (2.92)
Research Growth Index	4.12 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (16.52)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (13.33%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (86.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.37	2	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
benzophenone benzophenone : The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups.	2.07	1	benzophenones	photosensitizing agent; plant metabolite
niclosamide Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48). niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.	2.37	2	benzamides; C-nitro compound; monochlorobenzenes; salicylanilides; secondary carboxamide	anthelminthic drug; anticoronaviral agent; antiparasitic agent; apoptosis inducer; molluscicide; piscicide; STAT3 inhibitor
zinc chloride zinc chloride: RN given refers to parent cpd. zinc dichloride : A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.	2.37	2	inorganic chloride; zinc molecular entity	astringent; disinfectant; EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor; Lewis acid
benzenesulfonic acid benzenesulfonic acid: RN given refers to parent cpd. benzenesulfonic acid : The simplest member of the class of a benzenesulfonic acids that consists of a benzene carrying a single sulfo group.	1.96	1	benzenesulfonic acids
benzoin [no description available]	2.07	1	benzoins; secondary alpha-hydroxy ketone	EC 3.1.1.1 (carboxylesterase) inhibitor
4-hydroxybenzophenone 4-hydroxybenzophenone: RN given refers to parent cpd	2.07	1	benzophenones
copper sulfate Copper Sulfate: A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.. copper(II) sulfate : A metal sulfate compound having copper(2+) as the metal ion.	2.36	2	metal sulfate	emetic; fertilizer; sensitiser
barium chloride barium chloride: RN given refers to parent cpd. barium chloride : The inorganic dichloride salt of barium.	2.37	2	barium salt; inorganic chloride	potassium channel blocker
cuprous chloride cuprous chloride: RN given refers to unlabeled cpd. copper(I) chloride : An inorganic chloride of copper in which the metal is in the +1 oxidation state.	2.37	2	copper molecular entity; inorganic chloride	agrochemical; molluscicide
barium Barium: An element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous.	2.37	2	alkaline earth metal atom; elemental barium
acid phosphatase Acid Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.	1.95	1

Condition	Relationship Strength	Studies
Anaplastic Astrocytoma [description not available]	2.07	1
Astrocytoma Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)	2.07	1
Cancer of Liver [description not available]	2.87	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.87	1
Bilharziasis [description not available]	2.36	2
Schistosomiasis Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.	7.36	2

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