Compounds > thiaplidiaquinone a
Page last updated: 2024-10-14

thiaplidiaquinone a

Description

thiaplidiaquinone A: a meroterpenoid with antineoplastic activity from Aplidium conicum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11319314
CHEMBL ID4079913
MeSH IDM0485443

Synonyms (3)

Synonym
thiaplidiaquinone a
6-[(1e)-2,6-dimethylhepta-1,5-dienyl]-4-[(2e)-3,7-dimethylocta-2,6-dienyl]-2-hydroxy-8,8-dioxo-6,9,10,11-tetrahydrochromeno[4,3-g][1,4]benzothiazine-7,12-dione
CHEMBL4079913
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1487411Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution method2017Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
AID1487413Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by broth microdilution method2017Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
AID1487407Inhibition of Trypanosoma brucei recombinant farnesyltransferase using dansyl peptide containing GCAIM as substrate in presence of farnesyl pyrophosphate after 15 mins by fluorescence assay2017Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
AID1487414Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method2017Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
AID1487410Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay2017Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
AID1487406Inhibition of recombinant human farnesyltransferase using dansyl-GCVLS as substrate in presence of farnesyl pyrophosphate after 15 mins by fluorescence assay2017Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
AID1487412Antibacterial activity against Staphylococcus intermedius isolate 1051997 after 24 hrs by broth microdilution method2017Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
AID1487408Antiplasmodial activity against chloroquine-resistant erythrocyte stage of Plasmodium falciparum FcM29-Cameroon infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition mea2017Bioorganic & medicinal chemistry, 08-15, Volume: 25, Issue:16
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.1510aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		2.1510C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		2.1510furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
streptomycin
[no description available]		2.1510antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
fti 276
FTI 276: a ras CAAX (C - Cys; A - aliphatic amino acid; X - Ser or Met) peptidomimetic; inhibits farnesyltransferase; FTI-277 is the methyl ester derivative of FTI-276		2.1510methionine derivative
ConditionIndicatedRelationship StrengthStudiesTrials