shizukaol-B has been researched along with artemisinin* in 1 studies
1 other study(ies) available for shizukaol-B and artemisinin
| Article | Year |
|---|---|
Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure-Activity Relationships.
Inspired by the discovery of the antimalarial drug artemisinin from a traditional Chinese medicine (TCM), a natural product library of 44 lindenane-type sesquiterpenoids was assessed for activities against the Dd2 chloroquine-resistant strain of the malaria parasite Plasmodium falciparum. These compounds were mainly isolated from plants of the Chloranthus genus, many species of which are named "Sikuaiwa" in TCM and have long been used to treat malaria. The compounds consisted of 41 sesquiterpenoid dimers and three monomers, including the 12 new dimers 1-12 isolated from Chloranthus fortunei. The results showed that 16 dimers exhibited potent antiplasmodial activities (<100 nM); in particular, compounds 1, 14, and 19 exhibited low nanomolar activities with IC Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Inhibitory Concentration 50; Magnoliopsida; Molecular Structure; Plants, Medicinal; Plasmodium falciparum; Structure-Activity Relationship | 2017 |