Page last updated: 2024-12-08

pyrrolomycin c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pyrrolomycin C: from Streptomyces strain SF-2080; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID133779
CHEMBL ID4570346
MeSH IDM0106750

Synonyms (9)

Synonym
pyrrolomycin c
antibiotic sf 2080c
methanone, (3,5-dichloro-2-hydroxyphenyl)(4,5-dichloro-1h-pyrrol-2-yl)-
(3,5-dichloro-2-hydroxyphenyl)(4,5-dichloro-1h-pyrrol-2-yl)methanone
81910-06-7
(3,5-dichloro-2-hydroxyphenyl)-(4,5-dichloro-1h-pyrrol-2-yl)methanone
DTXSID601002299
CHEMBL4570346 ,
bdbm50530363
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Class A sortase SrtA Staphylococcus aureusIC50 (µMol)300.00000.30002.86005.9000AID1614998
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1614998Inhibition of Staphylococcus aureus SrtA using dabcyl-QALPETGEE-edans as substrate preincubated for 1 hr followed by substrate addition and measured at 1 min interval for 1 hr by fluorescence assay2019Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
Pyrrolomycins as antimicrobial agents. Microwave-assisted organic synthesis and insights into their antimicrobial mechanism of action.
AID1614997Antibiofilm activity against Staphylococcus aureus ATCC 25923 after 24 hrs by crystal violet staining based assay2019Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
Pyrrolomycins as antimicrobial agents. Microwave-assisted organic synthesis and insights into their antimicrobial mechanism of action.
AID1614999Antibiofilm activity against Pseudomonas aeruginosa ATCC 15442 after 24 hrs by crystal violet staining based assay2019Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
Pyrrolomycins as antimicrobial agents. Microwave-assisted organic synthesis and insights into their antimicrobial mechanism of action.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (50.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.13 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]