Compounds > tln 4601
Page last updated: 2024-12-11

tln 4601

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

diazepinomicin: an alkaloid from the culture of a marine actinomycete of the genus Micromonospora; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9868980
CHEMBL ID550961
CHEBI ID156321
MeSH IDM0546510

Synonyms (29)

Synonym
eco-04601
diazepinomicin
tln-4601
bu-4664l
eco-4601
733035-26-2
1,3,10-trihydroxy-5-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trienyl]-11h-benzo[b][1,4]benzodiazepin-6-one
CHEBI:156321
amo-01
CHEMBL550961
unii-yph994y0rf
11h-dibenzo(b,e)(1,4)diazepin-11-one, 5,10-dihydro-4,6,8-trihydroxy-10-((2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)-
4,6,8-trihydroxy-10-(3,7,11-trimethyldodeca-2,6,10-trienyl)-5,10-dihydrodibenzo(b,e)(1,4)diazepin-11-one
eco 4601
yph994y0rf ,
tln4601
tln 4601
179981-40-9
DTXSID40223539
bdbm50481798
DB12420
SALVHVNECODMJP-GNUCVDFRSA-N
4,6,8-trihydroxy-10-((2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)-5h-dibenzo[b,e][1,4]diazepin-11(10h)-one
HY-N6674
CS-0002631
Q27294642
BS-1201
diazepinomicin; bu-4664l; eco 04601
AKOS040741630

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" dosing was followed by rapid elimination of the drug and was ineffective."( Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand.
Beaudry, F; Berger, F; Falardeau, P; Farnet, CM; Gourdeau, H; McAlpine, JB; Ranger, M; Simard, B, 2008)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
cathepsin L (EC 3.4.22.15) inhibitorAn EC 3.4.22.* (cysteine endopeptidase) inhibitor which interferes with the action of cathepsin L (EC 3.4.22.15).
antioxidantA substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
dibenzodiazepineAny organic heterotricyclic compound with a skeleton consisting of two benzene rings fused to a diazepine ring.
secondary amineA compound formally derived from ammonia by replacing two hydrogen atoms by hydrocarbyl groups.
farnesane sesquiterpenoid
triolA chemical compound containing three hydroxy groups.
olefinic compoundAny organic molecular entity that contains at least one C=C bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID457152Antiinvasive activity against mouse Colon 26-L5 by Matrigel assay2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
AID457165Inhibition of MMP92010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
AID422277Antimicrobial activity against vancomycin-resistant Enterococcus faecium 379 NC12204 after 18 hrs by broth dilution method2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Evaluating indole-related derivatives as precursors in the directed biosynthesis of diazepinomicin analogues.
AID422281Antimicrobial activity against Candida albicans 54 CA300 after 18 hrs by broth dilution method2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Evaluating indole-related derivatives as precursors in the directed biosynthesis of diazepinomicin analogues.
AID457164Inhibition of MMP22010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
AID457163Antiangiogenic activity against HUVEC cells assessed as inhibition of vascular formation after 6 hrs by wound healing assay2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
AID1888524Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition by MTT assay2022Bioorganic & medicinal chemistry letters, 01-01, Volume: 55Synthesis and biological evaluation of BU-4664L derivatives as potential anticancer agents.
AID457154Antiinvasive activity against mouse Renca by Matrigel assay2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
AID457168Antiinvasive activity against HUVEC assessed as inhibition of cell migration after 6 hrs by Matrigel assay2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
AID422276Antimicrobial activity against methicillin-resistant Staphylococcus aureus 310 SSC8224 after 18 hrs by broth dilution method2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Evaluating indole-related derivatives as precursors in the directed biosynthesis of diazepinomicin analogues.
AID457160Cytotoxicity against HUVEC cells2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
AID457156Cytotoxicity against mouse Colon 26-L5 cells2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
AID422275Antimicrobial activity against Staphylococcus aureus 375 ATCC 3538p after 18 hrs by broth dilution method2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Evaluating indole-related derivatives as precursors in the directed biosynthesis of diazepinomicin analogues.
AID422280Antimicrobial activity against Escherichia coli 442 GC4559 after 18 hrs by broth dilution method2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Evaluating indole-related derivatives as precursors in the directed biosynthesis of diazepinomicin analogues.
AID422278Antimicrobial activity against Enterococcus faecium 436 ID3151 after 18 hrs by broth dilution method2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Evaluating indole-related derivatives as precursors in the directed biosynthesis of diazepinomicin analogues.
AID457162Antiinvasive activity against mouse Colon 26-L5 assessed as inhibition of cell migration after 6 hrs by Matrigel assay2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
AID422279Antimicrobial activity against Escherichia coli 389 GC4560 expressing imp after 18 hrs by broth dilution method2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Evaluating indole-related derivatives as precursors in the directed biosynthesis of diazepinomicin analogues.
AID457158Cytotoxicity against mouse Renca cells2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
AID1888525Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition by MTT assay2022Bioorganic & medicinal chemistry letters, 01-01, Volume: 55Synthesis and biological evaluation of BU-4664L derivatives as potential anticancer agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (41.67)29.6817
2010's6 (50.00)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.82 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (8.33%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
diazepam
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.		2.04101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.0510pyrrole;
secondary amine
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		2.0510dihydrogen
pyrroxamycin
pyrroxamycin: isolated from Streptomyces sp. S46506; structure given in first source		2.0510benzodioxine
fumagillin
[no description available]		2.0510antibiotic antifungal drug;
carboxylic ester;
dicarboxylic acid monoester;
meroterpenoid;
organooxygen heterocyclic antibiotic;
spiro-epoxide		angiogenesis inhibitor;
antibacterial drug;
antimicrobial agent;
antiprotozoal drug;
fungal metabolite;
methionine aminopeptidase 2 inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Invasiveness, Neoplasm
[description not available]		02.0510
Benign Neoplasms, Brain
[description not available]		04.1331
Glial Cell Tumors
[description not available]		02.4520
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		04.1331
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)		02.4520
Astrocytoma, Grade IV
[description not available]		03.4611
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		15.4611