Compounds > psammaplysin f
Page last updated: 2024-11-13

psammaplysin f

Description

psammaplysin F: isolated from sponge, Aplysinella sp.; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID46888580
CHEMBL ID1095507
MeSH IDM0280259

Synonyms (3)

Synonym
CHEMBL1095507
psammaplysin f
bdbm50493051
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID478227Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by fluorescence assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp.
AID766159Antibacterial activity against methicillin-resistant Staphylococcus aureus MW2 assessed as growth inhibition at 50 uM after 5 hrs by BacTiter-Glo microbial assay relative to control2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766174Antibacterial activity against Enterococcus faecalis NCTC 775 after 20 to 24 hrs by two-fold broth microdilution method2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID478226Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 after 72 hrs by fluorescence assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp.
AID766172Antibacterial activity against Bacillus cereus NCTC 7464 after 20 to 24 hrs by two-fold broth microdilution method2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766175Antibacterial activity against Staphylococcus aureus 1H after 20 to 24 hrs by two-fold broth microdilution method2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766160Antibacterial activity against Staphylococcus aureus 1H assessed as daughter cells lacking DNA at half MIC after 5 hrs by three dimensional structured illumination microscopy2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766170Disruption of plasma membrane integrity in Staphylococcus aureus 1H assessed as extracellular ATP release at 20 uM after 15 to 120 mins by BacTiter-Glo microbial assay relative to control2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766176Antibacterial activity against Staphylococcus aureus NCTC 6571 after 20 to 24 hrs by two-fold broth microdilution method2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766183Antibacterial activity against penicillin-resistant Staphylococcus aureus 1H assessed as growth inhibition at 50 uM after 5 hrs by BacTiter-Glo microbial assay relative to control2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766173Antibacterial activity against methicillin-resistant Staphylococcus aureus MW2 after 20 to 24 hrs by two-fold broth microdilution method2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766166Antibacterial activity against Staphylococcus aureus 1H assessed as small daughter cells without swelling at half MIC after 5 hrs by phase contrast microscopy2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766182Antibacterial activity against Enterococcus faecalis NCTC 775 assessed as growth inhibition at 50 uM after 5 hrs by BacTiter-Glo microbial assay relative to control2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766161Antibacterial activity against Staphylococcus aureus 1H assessed as improper segregation of chromosome at half MIC after 5 hrs by three dimensional structured illumination microscopy2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766171Antibacterial activity against methicillin-resistant Staphylococcus aureus USA-300 after 20 to 24 hrs by two-fold broth microdilution method2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766181Antibacterial activity against Bacillus cereus NCTC 7464 assessed as growth inhibition at 50 uM after 5 hrs by BacTiter-Glo microbial assay relative to control2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766184Antibacterial activity against Staphylococcus aureus NCTC 6571 assessed as growth inhibition at 50 uM after 5 hrs by BacTiter-Glo microbial assay relative to control2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID478229Cytotoxicity against human HEK293 cells after 72 hrs by Alamar blue assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp.
AID766168Antibacterial activity against Staphylococcus aureus 1H assessed as long branch like strings of cellular debris at half MIC after 5 hrs by phase contrast microscopy2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
AID766158Antibacterial activity against methicillin-resistant Staphylococcus aureus USA-300 assessed as growth inhibition at 50 uM after 5 hrs by BacTiter-Glo microbial assay relative to control2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0510aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		8.3460amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
sorafenib
[no description available]		7.2110(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
phenylureas;
pyridinecarboxamide		angiogenesis inhibitor;
anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
ferroptosis inducer;
tyrosine kinase inhibitor
bortezomib
[no description available]		7.2110amino acid amide;
L-phenylalanine derivative;
pyrazines		antineoplastic agent;
antiprotozoal drug;
protease inhibitor;
proteasome inhibitor
gentamicin sulfate
[no description available]		2.0810
ceratinamine
[no description available]		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Staphylococcal
[description not available]		02.0810
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.0810
Cancer of Prostate
[description not available]		02.2510
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.2510
Benign Neoplasms
[description not available]		02.2110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.2110
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