Compounds > enmein
Page last updated: 2024-12-08

enmein

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

enmein: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID352542
CHEMBL ID453801
CHEBI ID70378
MeSH IDM0050887

Synonyms (18)

Synonym
nsc-526961
sculponeatin d
enmein
3776-39-4
C09090
NSC526961 ,
chebi:70378 ,
enemin
CHEMBL453801
AC-35050
CS-0032112
HY-N5028
Q27104988
(1s,4s,6s,8r,9r,12s,13s,16r)-6,9-dihydroxy-7,7-dimethyl-17-methylidene-3,10-dioxapentacyclo[14.2.1.01,13.04,12.08,12]nonadecane-2,18-dione
2,13-dihydroxy-1,1-dimethyl-7-methylidenedecahydro-5h,11h-5a,8-methanocyclohepta[c]furo[3,4-e][1]benzopyran-5,6(7h)-dione
DTXSID20958812
AKOS040760163
FS-7751
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
delta-lactoneA lactone having a six-membered lactone ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1058648Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
AID471320Cytotoxicity against human K562 cells after 48 hrs2009Journal of natural products, Oct, Volume: 72, Issue:10
ent-Kaurane and cembrane diterpenoids from Isodon sculponeatus and their cytotoxicity.
AID1058647Cytotoxicity against human SW480 cells after 48 hrs by MTS assay2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
AID471322Cytotoxicity against human HepG2 cells after 48 hrs2009Journal of natural products, Oct, Volume: 72, Issue:10
ent-Kaurane and cembrane diterpenoids from Isodon sculponeatus and their cytotoxicity.
AID1550695Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by MTT assay2019European journal of medicinal chemistry, Jun-01, Volume: 171Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation.
AID1550699Cytotoxicity against human L02 cells assessed as reduction in cell viability after 72 hrs by MTT assay2019European journal of medicinal chemistry, Jun-01, Volume: 171Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation.
AID1058650Cytotoxicity against human SMMC7721 cells after 48 hrs by MTS assay2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
AID1058649Cytotoxicity against human A549 cells after 48 hrs by MTS assay2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
AID1550693Antiproliferative activity against human Bel7402 cells assessed as reduction in cell viability after 72 hrs by MTT assay2019European journal of medicinal chemistry, Jun-01, Volume: 171Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation.
AID1550696Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTT assay2019European journal of medicinal chemistry, Jun-01, Volume: 171Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation.
AID471321Cytotoxicity against human A549 cells after 48 hrs2009Journal of natural products, Oct, Volume: 72, Issue:10
ent-Kaurane and cembrane diterpenoids from Isodon sculponeatus and their cytotoxicity.
AID1550694Antiproliferative activity against human SGC7901 cells assessed as reduction in cell viability after 72 hrs by MTT assay2019European journal of medicinal chemistry, Jun-01, Volume: 171Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation.
AID1058651Cytotoxicity against human HL60 cells after 48 hrs by MTS assay2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
AID1550698Antiproliferative activity against human K562 cells assessed as reduction in cell viability after 72 hrs by MTT assay2019European journal of medicinal chemistry, Jun-01, Volume: 171Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation.
AID1550697Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay2019European journal of medicinal chemistry, Jun-01, Volume: 171Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (12.50)18.7374
1990's1 (4.17)18.2507
2000's5 (20.83)29.6817
2010's13 (54.17)24.3611
2020's2 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 53.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index53.71 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index83.44 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (53.71)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
5-hydroxytryptophan
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.. 5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.		3.1410hydroxytryptophanhuman metabolite;
neurotransmitter
iodine
Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..		6.9510diatomic iodinenutrient
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.2110nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
mechlorethamine
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.		2.1710nitrogen mustard;
organochlorine compound		alkylating agent
spironolactone
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827). spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.		2.79303-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester		aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.		1.9910penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		2.2110alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		1.9510benzenes;
phenyl acetates
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0810taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
barium oxide
[no description available]		1.9310
benzyloxycarbonylleucyl-leucyl-leucine aldehyde
benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor. N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.		2.0810amino aldehyde;
carbamate ester;
tripeptide		proteasome inhibitor
oridonin
[no description available]		2.2110cyclic hemiketal;
enone;
ent-kaurane diterpenoid;
organic heteropentacyclic compound;
secondary alcohol		angiogenesis inhibitor;
anti-asthmatic agent;
antibacterial agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite
lead
Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.		6.9510carbon group element atom;
elemental lead;
metal atom		neurotoxin
ovatodiolide
ovatodiolide: from Anisomeles indica; structure in first source		2.0510
nodosin
nodosin: has anti-inflammatory activity; isolated from Isodon serra; structure in first source		2.4720delta-lactonemetabolite
eriocalyxin b
eriocalyxin B: isolated from Isodon Eriocalyx; structure in first source		2.0310
ponicidin
ponicidin: from the stems and leaves of Rabdosa nervosa		2.3110dioxanesmetabolite
oridonin
[no description available]		3.4670
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0210
Anasarca
[description not available]		02.0210
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.0210