pleiocarpamine: corymine compound is the main indole alkaloid; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 5385014 |
| CHEMBL ID | 3338254 |
| CHEBI ID | 141939 |
| MeSH ID | M0295830 |
| Synonym |
|---|
| pleocarpamine |
| pleiocarpamine |
| 6393-66-4 |
| nsc374523 |
| nsc-374523 |
| CHEBI:141939 |
| DTXSID80419616 |
| CHEMBL3338254 |
| (16s,19e)-17-methoxy-17-oxo-19,20-didehydro-1,16-cyclocorynan |
| Q15425259 |
| methyl (13e,14s,16s,18s)-13-ethylidene-1,11-diazapentacyclo[12.3.1.02,7.08,17.011,16]octadeca-2,4,6,8(17)-tetraene-18-carboxylate |
| nsc 374523 |
| 4j3pv95anl , |
| unii-4j3pv95anl |
| 2h-2,12-methanoindolo(2,3-a)quinolizine-13-carboxylic acid, 3-ethylidene-1,3,4,6,7,12b-hexahydro-, methyl ester, (2s,3e,12bs,13s)- |
| (+)-pleiocarpamine |
| Class | Description |
|---|---|
| monoterpenoid indole alkaloid | A terpenoid indole alkaloid which is biosynthesised from L-tryptophan and diisoprenoid (usually secolaganin) building blocks. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1163733 | Cytotoxicity against vincristine-sensitive human KB cells | 2014 | Journal of natural products, Sep-26, Volume: 77, Issue:9 | Oxidized derivatives of macroline, sarpagine, and pleiocarpamine alkaloids from Alstonia angustifolia. |
| AID1163734 | Cytotoxicity against vincristine-resistant human KB/VJ300 cells | 2014 | Journal of natural products, Sep-26, Volume: 77, Issue:9 | Oxidized derivatives of macroline, sarpagine, and pleiocarpamine alkaloids from Alstonia angustifolia. |
| AID1163735 | Cytotoxicity against multi-drug resistant human KB/VJ300 cells in presence of 0.1 ug/ml vincristine | 2014 | Journal of natural products, Sep-26, Volume: 77, Issue:9 | Oxidized derivatives of macroline, sarpagine, and pleiocarpamine alkaloids from Alstonia angustifolia. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||