pleiocarpamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

pleiocarpamine: corymine compound is the main indole alkaloid; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	5385014
CHEMBL ID	3338254
CHEBI ID	141939
MeSH ID	M0295830

Synonyms (16)

Synonym
pleocarpamine
pleiocarpamine
6393-66-4
nsc374523
nsc-374523
CHEBI:141939
DTXSID80419616
CHEMBL3338254
(16s,19e)-17-methoxy-17-oxo-19,20-didehydro-1,16-cyclocorynan
Q15425259
methyl (13e,14s,16s,18s)-13-ethylidene-1,11-diazapentacyclo[12.3.1.02,7.08,17.011,16]octadeca-2,4,6,8(17)-tetraene-18-carboxylate
nsc 374523
4j3pv95anl ,
unii-4j3pv95anl
2h-2,12-methanoindolo(2,3-a)quinolizine-13-carboxylic acid, 3-ethylidene-1,3,4,6,7,12b-hexahydro-, methyl ester, (2s,3e,12bs,13s)-
(+)-pleiocarpamine

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
monoterpenoid indole alkaloid	A terpenoid indole alkaloid which is biosynthesised from L-tryptophan and diisoprenoid (usually secolaganin) building blocks.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID1163733	Cytotoxicity against vincristine-sensitive human KB cells	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Oxidized derivatives of macroline, sarpagine, and pleiocarpamine alkaloids from Alstonia angustifolia.
AID1163734	Cytotoxicity against vincristine-resistant human KB/VJ300 cells	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Oxidized derivatives of macroline, sarpagine, and pleiocarpamine alkaloids from Alstonia angustifolia.
AID1163735	Cytotoxicity against multi-drug resistant human KB/VJ300 cells in presence of 0.1 ug/ml vincristine	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Oxidized derivatives of macroline, sarpagine, and pleiocarpamine alkaloids from Alstonia angustifolia.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (11.11)	18.2507
2000's	0 (0.00)	29.6817
2010's	7 (77.78)	24.3611
2020's	1 (11.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
2,3-dihydroxybenzoic acid 2,3-dihydroxybenzoic acid: RN given refers to parent cpd. dihydroxybenzoic acid : Any member of the class of hydroxybenzoic acids carrying two phenolic hydroxy groups on the benzene ring and its derivatives.. 2,3-dihydroxybenzoic acid : A dihydroxybenzoic acid that is benzoic acid substituted by hydroxy groups at positions 2 and 3. It occurs naturally in Phyllanthus acidus and in the aquatic fern Salvinia molesta.	2.15	1	dihydroxybenzoic acid	human xenobiotic metabolite; plant metabolite
gamma-aminobutyric acid gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	1.99	1	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule
glycine [no description available]	1.99	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
strictosidine [no description available]	2.31	1	alkaloid ester; beta-D-glucoside; indole alkaloid; methyl ester
thiourea Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.	2.1	1	one-carbon compound; thioureas; ureas	antioxidant; chromophore
corymine corymine: RN given refers to (3beta,16R,17R)-isomer; structure in first source	1.99	1
disilver oxide [no description available]	2.15	1
alstonerine alstonerine: from Alstonia; structure in first source	2.1	1
macroline macroline: structure in first source	2.78	3
sarpagine sarpagine: structure in first source. sarpagine : An indole alkaloid that is sarpagan bearing hydroxy groups at positions 10 and 17.	2.49	2	indole alkaloid; phenols; primary alcohol; secondary amino compound; tertiary amino compound
strictamine strictamine: structure	7.31	1

Condition	Indicated	Relationship Strength	Studies	Trials
Acute Confusional Senile Dementia [description not available]	0	2.08	1	0
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	0	2.08	1	0

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