Compounds > n-nitrosopropranolol
Page last updated: 2024-11-07

n-nitrosopropranolol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-nitrosopropranolol: structure for (E)-isomer & RN given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID128614
CHEMBL ID143513
MeSH IDM0113649

Synonyms (12)

Synonym
brn 4875981
ccris 4203
n-nitrosopropanolol
n-nitrosopropranolol
2-propanol, 1-((1-methylethyl)nitrosoamino)-3-(1-naphthalenyloxy)-
CHEMBL143513
84418-35-9
n-(2-hydroxy-3-naphthalen-1-yloxypropyl)-n-propan-2-ylnitrous amide
DTXSID301004684
n-{2-hydroxy-3-[(naphthalen-1-yl)oxy]propyl}-n-propan-2-ylnitrous amide
EN300-18585762
1-(naphthalen-1-yloxy)-3-[nitroso(propan-2-yl)amino]propan-2-ol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID191494Toxicity (Ames Salmonella Test) in the presence of rat liver S-9 fraction in TA-100 strain (4*10e6 dilution)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Derivatives of beta-adrenergic antagonists. N-Nitrosopropranolol and N-hydroxypropranolol and its aldonitrone.
AID184702Mutagenic activity (Ames Salmonella Test) in the presence of rat liver S-9 fraction in TA-100 strain1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Derivatives of beta-adrenergic antagonists. N-Nitrosopropranolol and N-hydroxypropranolol and its aldonitrone.
AID184703Mutagenic activity (Ames Salmonella Test) in the presence of rat liver S-9 fraction in TA-100 strain at a conc. of 1000 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Derivatives of beta-adrenergic antagonists. N-Nitrosopropranolol and N-hydroxypropranolol and its aldonitrone.
AID191495Toxicity (Ames Salmonella Test) in the presence of rat liver S-9 fraction in TA-100 strain (4*10e7 dilution)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Derivatives of beta-adrenergic antagonists. N-Nitrosopropranolol and N-hydroxypropranolol and its aldonitrone.
AID184705Mutagenic activity (Ames Salmonella Test) in the presence of rat liver S-9 fraction in TA-98 strain1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Derivatives of beta-adrenergic antagonists. N-Nitrosopropranolol and N-hydroxypropranolol and its aldonitrone.
AID184706Mutagenic activity (Ames Salmonella Test) in the presence of rat liver S-9 fraction in TA-98 strain at a conc. of 1000 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Derivatives of beta-adrenergic antagonists. N-Nitrosopropranolol and N-hydroxypropranolol and its aldonitrone.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.27 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.39 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydrochloric acid
Hydrochloric Acid: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.. hydrogen chloride : A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.		1.9810chlorine molecular entity;
gas molecular entity;
hydrogen halide;
mononuclear parent hydride		mouse metabolite
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)		2.3820monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
atenolol
Atenolol: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.. atenolol : An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.		210ethanolamines;
monocarboxylic acid amide;
propanolamine		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
sympatholytic agent;
xenobiotic
propranolol
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.. propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.		3.0750naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
propranolol hydrochloride
Inderex: combination of above cpds; used in treatment of hypertension		1.9610hydrochloride
2-hydroxylaminopropane
2-hydroxylaminopropane: RN given refers to parent cpd		1.9610
sodium nitrite
Sodium Nitrite: Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.. sodium nitrite : An inorganic sodium salt having nitrite as the counterion. Used as a food preservative and antidote to cyanide poisoning.		1.9610inorganic sodium salt;
nitrite salt		antidote to cyanide poisoning;
antihypertensive agent;
antimicrobial food preservative;
food antioxidant;
poison
ConditionIndicatedRelationship StrengthStudiesTrials