ly 106737 has been researched along with naltrexone in 5 studies
| Studies (ly 106737) | Trials (ly 106737) | Recent Studies (post-2010) (ly 106737) | Studies (naltrexone) | Trials (naltrexone) | Recent Studies (post-2010) (naltrexone) |
|---|---|---|---|---|---|
| 8 | 0 | 0 | 8,745 | 1,228 | 2,642 |
| Protein | Taxonomy | ly 106737 (IC50) | naltrexone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 1 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.0051 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0063 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.006 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.006 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.0319 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0093 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0377 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0076 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0004 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cantrell, BE; Johnson, BG; Leander, JD; Mendelsohn, LG; Mitch, CH; Reel, JK; Snoddy, J; Zimmerman, DM | 1 |
| Cantrell, BE; Carroll, FI; Dersch, CM; Flippen-Anderson, JL; George, CF; Mascarella, SW; Partilla, JS; Rothman, RB; Thomas, JB; Zheng, X; Zimmerman, DM | 1 |
| Burgess, JP; Cantrell, BE; Carroll, FI; Flippen-Anderson, JL; George, CF; Mascarella, SW; McCullough, KB; Rothman, RB; Thomas, JB; Xu, H; Zimmerman, DM | 1 |
| Belanger, S; DeHaven, RN; Dolle, RE; Goodman, AJ; Graczyk, TM; Herbertz, T; Le Bourdonnec, B; Michaut, M; Yap, GP; Ye, HF | 1 |
| Belanger, S; DeHaven, RN; Dolle, RE; Goodman, AJ; Graczyk, TM; Le Bourdonnec, B; Seida, PR | 1 |
5 other study(ies) available for ly 106737 and naltrexone
| Article | Year |
|---|---|
Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors.
Topics: Analgesia; Animals; Diuresis; Furans; Male; Mice; Molecular Structure; Morphine; Piperidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 1993 |
N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.
Topics: Animals; Crystallography, X-Ray; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Molecular Conformation; Morphinans; Narcotic Antagonists; Putamen; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1998 |
N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.
Topics: Animals; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Isoquinolines; Narcotic Antagonists; Piperidines; Structure-Activity Relationship | 1998 |
Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Models, Molecular; Molecular Conformation; Piperidines; Radioligand Assay; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2006 |
Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Structure; Pyrazines; Pyridines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2006 |